Formulation and in vitro/in vivo evaluation of naproxen mucoadhesive buccal patches for local effect

Hassan, Mohamed A.; Barakat, Nahla S.; El-Badry, Mahmoud; Shehata, Shereen M.

doi:10.1016/s1773-2247(11)50068-1

Cited by 18 publications

(11 citation statements)

References 21 publications

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“…According to the Korsmeyer–Peppas model, even though FPH04 has a higher constant ( k = 0.2800 for FPH04 and 0.2255 for FPH03) contributing to faster release at earlier times, the higher exponential term of FPH03 ( n = 0.6604 for FPH03 and 0.4875 for FPH04) allows for faster release at later times. Similar effects have been described before in films combining HPMC and ERL . Among the various materials studied, Hassan et al .…”

Section: Resultssupporting

confidence: 76%

Protein-coated nanoparticles embedded in films as delivery platforms

Morales

Ross

McConville

2013

Journal of Pharmacy and Pharmacology

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Section: Resultssupporting

confidence: 76%

Protein-coated nanoparticles embedded in films as delivery platforms

Morales

Ross

McConville

2013

Journal of Pharmacy and Pharmacology

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“…The rate of stirring was 50 rpm, which was believed to mimic the buccal cavity environment. The time spent for the film to completely erode or detach from mucosa was recorded as the in vitro mucoadhesion time (Hassan et al, 2011). …”

Section: Methodsmentioning

confidence: 99%

Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

2018

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A growing concern about Candida albicans is the emergence of high incidence of resistance against antifungal agents, which requires searching for new medications or improving the response to the existing members. The objective of this work was to evaluate the effectiveness of the miconazole in the absence and presence of urea, as a penetration enhancer, against C. albicans. In addition to, formulating both of them in a polymer film to be used topically for treatment of mouth fungal white patches caused by C. albicans. A synergistic effect was recorded between this imidazole and urea against the test strain. Miconazole MIC (32 mg/L) was dramatically reduced to 0.0625 mg/L following combination with urea. Transmission electron microscopy explained the mechanisms of action mediated by the test agents. Minimal fungicidal dose of miconazole combined with urea showed early apoptotic cells with condensed chromatin and small blebs. Cytoplasmic leakage and necrosis in some cells was observed at high fungicidal dose. Buccal bioadhesive films were prepared using increasing values of the drug MIC and urea. The physicochemical characters of the prepared films including; film weight, thickness, swelling index, drug content, folding endurance, surface pH, bioadhesion force and time and drug release kinetics, were studied. Microbiological evaluation of all prepared films showed an increase in the inhibition zone diameters for films containing increasing concentrations of both miconazole and urea in a concentration-dependent manner (30–40 mm) compared to miconazole alone (18 mm). Based on our results, the prepared films are promising for buccal administration of miconazole/urea showing synergistic effect for treatment of C. albicans infection.

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“…The polymeric solution was stirred on magnetic stirrer for 2 h. The solid dispersion equivalent to 120 mg LVS was added followed by addition of plasticizer 0.7 % glycerol and 20 mg of menthol as permeation enhancer. The mixture was stirred for 30 min and then poured into Petri dish, which is stored at 4 °C to remove air bubbles entrapped and finally dried at 37 °C for 4 h. The dried films were cut into 1 cm 2 and packed in aluminum foil and stored [4,10].…”

Section: Transbuccal Film By Using Hpmc E5mentioning

confidence: 99%

Transbuccal Delivery of Spray Dried Lovastatin From Mucoadhesive Buccal Patches and in Vitro Characterization

Sharannavar

Gadad

2019

Int J App Pharm

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Objective: The aim of the present work was to develop and characterize mucoadhesive film of spray dried Lovastatin (LVS) for buccal delivery to enhance bioavailability. Methods: Mucoadhesive films were prepared by solvent casting technique by using different polymers HPMCK4M, HPMC E5LV and chitosan. The successful patches were evaluated for film thickness, weight, content uniformity, surface pH, swelling index, folding endurance, ex-vivo residence time, ex-vivo bioadhesion test, in vitro drug release, ex-vivo drug permeation and stability study. Results: The thickness of all prepared patches ranged from 0.21±0.07 to 1.5±0.39 mm, the weight of the film 89.10±0.6 to 128.57±0.3 mg, drug content 85.47±0.87 to 97.33±0.31%, surface pH 5.6±0.67 to 7.6±0.98, swelling index 23.0±4.1 to 76.5±3.6%, folding endurance 165±1.9 to 350±2.5 respectively. Ex-vivo residence time ranged from 2.2±0.08to 8.2±0.17 h and ex-vivo bioadhesive strength 30±0.64 to 66±0.43 g. The formulations with HPMC E5 shown short period of residence time and shows weak force of adhesion., which might be because of low viscosity of the polymer which resulted into weak adhesion. The percentage drug release and ex-vivo drug permeation was in the following descending order HPMC K4M>HPMC E5LV>chitosan. These results confirm the extension of drug release in case of ionic polymer chitosan. The kinetics data shows that drug release and permeation follows nonfiction diffusion. Accelerated stability data revealed that there is no significant change in drug content, in vitro drug release and ex-vivo permeation. Conclusion: It can be concluded that mucoadhesive buccal patch is a promising dosage form to enhance the drug bioavailability by preventing first-pass metabolism thus providing better therapeutic efficacy.

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Formulation and in vitro/in vivo evaluation of naproxen mucoadhesive buccal patches for local effect

Cited by 18 publications

References 21 publications

Protein-coated nanoparticles embedded in films as delivery platforms

Protein-coated nanoparticles embedded in films as delivery platforms

Miconazole-Urea in a Buccal Film as a New Trend for Treatment of Resistant Mouth Fungal White Patches

Transbuccal Delivery of Spray Dried Lovastatin From Mucoadhesive Buccal Patches and in Vitro Characterization

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