2023
DOI: 10.22159/ijap.2023v15i6.48981
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Formulation and in Vivo Evaluation of Pemigatinib Super Saturable Self-Nano Emulsifying Drug Delivery System

MUTHADI RADHIKA REDDY,
SHIVA KUMAR GUBBIYAPPA

Abstract: Objective: Pemigatinib is an active component in treatment of cholangiocarcinoma, but the low solubility and bioavailability of Pemigatinib limit its wide application. The aim of the present study was to prepare and evaluate supersaturable self-nanoemulsifying drug delivery systems (sSNEDDS) followed by investigating and comparing the pharmacokinetic profiles of Pemigatinib and Pemigatinib sSNEDDS in rat plasma by HPLC. Methods: Pemigatinib loaded SNEDDS were obtained by dissolving drug in the isotropic mixtur… Show more

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