Formulation and optimisation of famotidine proniosomes: an<i>in vitro</i>and<i>ex vivo</i>study

Mokale, Vinod; Patil, Harshada I.; Patil, Ajit; Shirude, Priyanka R.; Naik, Jitendra

doi:10.1080/17458080.2015.1030711

Cited by 28 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The correlation coefficient values indicated that the profile of drug release followed Higuchi diffusion model. These results indicated that the transport mechanism of the drug from clopidogrel proniosomes is by diffusion [41].…”

Section: Kinetic Treatmentmentioning

confidence: 80%

Enhancement of Dissolution Characteristics of Clopidogrel Bisulphate by Proniosomes

Mazyed

Zakaria

2019

Int J App Pharm

View full text Add to dashboard Cite

Objective: The present investigation aims to formulate and evaluate proniosomes of clopidogrel bisulphate for improving its dissolution characteristics. Methods:The slurry method was used for the preparation of proniosomes of clopidogrel using cholesterol, sorbitan monostearate (Span 60) and maltodextrin as a carrier. Clopidogrel proniosomes were evaluated for their entrapment efficiency and in vitro drug release. The best formula (F1) that achieved maximum drug release was further evaluated by measurement of the angle of repose, morphological examination, determination of vesicle size, determination of zeta potential, Fourier transform infrared spectroscopy and differential thermal analysis. The in vivo behavior of the selected proniosomal formula (F1) was studied by measuring the antiplatelet activity in adult male mice. Results:The entrapment efficiency of clopidogrel proniosomes was in the range of 83.04±1.99 to 90.14±0.30. % drug released from proniosomal formulations was in the range of 79.73±0.35 to 97.70±1.10 % within 4 h. Clopidogrel proniosomes significantly enhanced the in vitro release of clopidogrel compared with the plain drug that achieved 61.77±2.22 % drug release. F1 significantly (p ≤ 0.001) increased the bleeding time and bleeding volume and significantly (p ≤ 0.05) prolonged prothrombin time and decreased prothrombin activity and increased the international normalized ratio (INR) compared to plain clopidogrel. Conclusion:The present investigation introduced proniosomes as a promising carrier for clopidogrel that could enhance its dissolution and pharmacological effect. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

show abstract

Section: Kinetic Treatmentmentioning

confidence: 80%

Enhancement of Dissolution Characteristics of Clopidogrel Bisulphate by Proniosomes

Mazyed

Zakaria

2019

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…[9] Proniosomes have been widely studied for systemic delivery of several classes of compounds and remarkable opportunities have been found in the transdermal delivery of drugs owing to their highly permeable ability. [10] Transdermal delivery of tenoxicam by proniosomes has been reported to significantly enhance the anti-inflammatory and analgesic effects as compared to the marketed tablets. [11] Similarly, the in vivo efficacy of mefenamic acid has been improved with proniosomal gel.…”

Section: Introductionmentioning

confidence: 99%

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Lather¹,

Sharma²,

Pandita³

2016

Journal of Experimental Nanoscience

View full text Add to dashboard Cite

Vesicular systems endow large opportunities for the transdermal delivery of therapeutics. The present study was designed to investigate the potential of a novel class of vesicular system 'proniosome' as a carrier for transdermal delivery of bromocriptine (BCT). Proniosome formulations were prepared by the coacervationphase separation method and the influence of factors like surfactant type and its amount, lipid concentration, cholesterol amount and drug content were studied. Span 60 was the most appropriate surfactant, and yielded vesicle size and percentage encapsulation efficiency of 1.3 mm and 98.9%, respectively. The developed system was characterised w.r.t. morphology, transition temperature, drug release, skin permeation and skin irritancy. Proniosomes exhibited a sustained release pattern of BCT in vitro. Skin permeation study revealed high penetration of proniosomes with sustained release of BCT through rat skin. The optimised proniosomal formulation showed enhanced transdermal flux of 16.15 mg/cm 2 /h as compared to 3.67 mg/cm 2 /h for drug dispersion. The developed formulations were observed as non-irritant to the rat skin and were found as quite stable at 4 and 25 C for 90 days w.r.t. vesicle size and drug content. The dried proniosomal formulation could act as a promising alternative to niosomes and preferably for transdermal delivery of BCT.

show abstract

“…Obtained proniosomal system was lyophilized for stabilization. Prior to lyophilization, the dispersion was frozen at -30 °C for 1 d. The frozen sample was subjected to freeze drying for 6 h and immediately used for formulation [14].…”

Section: Preparation Of Proniosomesmentioning

confidence: 99%

Mucoadhesive Polymeric Films of Acyclovir Proniosomes for Buccal Administration

et al. 2021

View full text Add to dashboard Cite

Objective: The aim of the present work was to formulate and evaluate proniosomes of the poorly soluble drug, acyclovir incorporated in mucoadhesive polymeric films for improved buccal mucosal permeability of the drug while achieving prolonged release. Methods: Acyclovir was formulated as proniosomes using Span 60 and cholesterol. The prepared proniosomes were loaded into mucoadhesive polymeric films prepared with varying quantities of carbopol 934P and HPMC K15M. The proniosome incorporated films were evaluated for physicomechanical characters, mucoadhesion, swelling index, drug content, in vitro drug release and ex vivo permeation through porcine buccal mucosa. Results: Hydration of the proniosomes produced spherical vesicles or niosomes, which was confirmed by Scanning Electron Microscopy. The optimized formulation selected on the basis of vesicle size, entrapment efficiency PDI, Zetz potential and in vitro drug release was selected for incorporation into mucoadhesive polymeric films. All the films showed excellent physicomechanical characters. Formulations with higher proportions of carbopol produced slower in vitro drug release. The kinetics of release of drug from all the formulations appeared to be zero-order based on their regression coefficient values. Comparative evaluation of ex vivo permeation from niosomal and non-niosomal films indicated that the former demonstrated improved mucosal permeation and drug release was also sustained for the 8 h period. Conclusion: Mucoadhesive films impregnated with acyclovir loaded proniosomes could be a potential approach for buccal delivery of acyclovir for improving its absorption and bioavailability.

show abstract

Formulation and optimisation of famotidine proniosomes: anin vitroandex vivostudy

Cited by 28 publications

References 10 publications

Enhancement of Dissolution Characteristics of Clopidogrel Bisulphate by Proniosomes

Enhancement of Dissolution Characteristics of Clopidogrel Bisulphate by Proniosomes

Proniosomal gel-mediated transdermal delivery of bromocriptine:in vitroandex vivoevaluation

Mucoadhesive Polymeric Films of Acyclovir Proniosomes for Buccal Administration

Contact Info

Product

Resources

About