2018
DOI: 10.22159/ijap.2018v10i2.23382
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Formulation and Optimization of Itraconazole Proniosomes Using Box Behnken Design

Abstract: Objective: The aim of the present study was to obtain an optimized formula of itraconazole (ITC) proniosomes using Box Behnken design.Methods: Itraconazole proniosomes were prepared using span 60 and/or brij 35 as surfactants, cholesterol and lecithin as a penetration enhancer by slurry method. Various trials have been carried out for investigation of proniosomes. Parameters such as entrapment efficiency (EE%), in vitro drug release, zeta potential, vesicle size and Transmission Electron Microscope were assess… Show more

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Cited by 6 publications
(5 citation statements)
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“…Zeta potential is a measure of the net charge of niosomes. This high charge on the vesicle surface produces repulsion between the vesicles that make them stable without agglomeration providing a uniformly distributed suspension [10]. The positive value of zeta potential could be attributed to the presence of the nitrogen atom in the structure of cationic clopidogrel bisulphate [47].…”
Section: Fig 4: Particle Size Distribution Curve Of Clopidogrel Pronmentioning
confidence: 99%
See 1 more Smart Citation
“…Zeta potential is a measure of the net charge of niosomes. This high charge on the vesicle surface produces repulsion between the vesicles that make them stable without agglomeration providing a uniformly distributed suspension [10]. The positive value of zeta potential could be attributed to the presence of the nitrogen atom in the structure of cationic clopidogrel bisulphate [47].…”
Section: Fig 4: Particle Size Distribution Curve Of Clopidogrel Pronmentioning
confidence: 99%
“…Proniosomes could overcome physical instability problems of niosomes [8] and offer better convenience of storage and transportation. Following hydration, proniosomes are converted to niosomes [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…Kumar et al succeeded in obtaining an optimized formulation of itraconazole niosomes with EE% of 73.03 ± 2.39%, a particle size of 272.3 nm, and a zeta potential of −47.2 ± 0.2 [ 47 ]. Samy et al developed itraconazole as proniosomes and were able to obtain an optimized formulation with 94.9 ± 0.36 % regarding the EE%, −30.15 ± 0.41 mV regarding zeta potential, and 340.48 ± 0.581 nm regarding the particle size [ 48 ].…”
Section: Resultsmentioning
confidence: 99%
“…Where A and B are emulsifiers, HLB Low is the HLB of lipophilic surfactant, and HLB High is the HLB of hydrophilic surfactant [50,51].…”
Section: Calculating Required Hlbmentioning
confidence: 99%