Formulation, characterization, and evaluation of orodispersible tablet of a model antidepressant drug

Jamakandi, VG; Kalsannavar, Chetan Prakash; Hiremath, S. P.; Dasanakoppa, FS; Kerur, SS

doi:10.4103/2349-5006.196330

Cited by 1 publication

(2 citation statements)

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“…Tablets containing 10mg taste masked ONH equivalent to 8mg OND were formulated by the direct compression method using various superdisintegrants like (CP) (3 and 4%) for F4 and F7 respectively , (CCS) (3%) for F5, (SSG) (3%) for F6 as shown in table (1 ) .…”

Section: Preparation Of Onh Fdtsmentioning

confidence: 99%

“…Oral drug delivery has been known for decades as the most widely utilized route of administration among all the routes that have been discovered for the systemic delivery of drugs through various pharmaceutical products of different dosage forms, because it is convenient, self-administration, compactness and easy manufacturing, accurate dosage and most importantly the patient compliance (1) . Administration of an oral drug delivery system having bitter taste with acceptable level of palatability has always been challenge in manufacturing of a formulation for pediatric and old age patients.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Evaluation of Fast Dissolving Tablets of Taste-Masked Ondansetron Hydrochloride by Solid Dispersion

Abdulqader¹,

Al-Khedairy²

2017

IJPS

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Ondansetron hydrochloride (ONH) is a very bitter, potent antiemetic drug used for the treatment and/or prophylaxis of chemotherapy or radiotherapy or postoperative induced emesis. The objective of this study is to formulate and evaluate of taste masked fast dissolving tablet (FDTs) of ONH to increase patient compliance. ONH taste masked granules were prepared by solid dispersion technique using Eudragit E100 polymer as an inert carrier. Solvent evaporation and fusion melting methods were used for such preparation. Completely taste masking with zero release of drug in phosphate buffer pH 6.8was obtained from granules prepared by solvent evaporation method using drug: polymer ratio of 1:2, from which four formulas pass pre-compression evaluation and compressed to FDTs and evaluated for their drug content, in-vitro disintegration time, in-vivo disintegration time, wetting time and in vitro drug release profile. F7 which is prepared from solid dispersion product equivalent to the required dose of ONH , Crosspovidone as superdisintegrant, Aspartame as sweetener ,Ross berry as flavor ,Polyvinylpyrolidone K30.3.as binder ,Avicil PH102 and , mannitol as diluents give best in- vitro, in-vivo disintegration time and best drug release profile. Key words: Ondansetron hydrochloride, taste masking, solid dispersion, Eudragit E100.

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Section: Preparation Of Onh Fdtsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%