Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

Arpa, Muhammet Davut; Ünükür, Melike Zeynep; Erim, Ümit Can

doi:10.29228/jrp.58

Cited by 5 publications

(3 citation statements)

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“…The peak at 1050 cm -1 of the HPMC spectrum represented C-O stretching vibration. The peak at 3417 cm -1 , on the other hand, demonstrated the out-of-plane bending vibration of the hydroxyl group [51]. The FTIR spectra of the formulations indicated the characteristic peaks of their components.…”

Section: Ftir Analysismentioning

confidence: 93%

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Davut ARPA,

DOĞAN,

GÜNDÜZ

et al. 2024

jrp

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Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different pharmacological effects such as benzoyl peroxide, isotretinoin, azelaic acid (AZE), and erythromycin are used alone or in combination. AZE cream (20%) has been frequently preferred in the treatment of mild and moderate acne in recent years. However, since AZE has poor solubility in water, its low permeability problems may occur. In this study, the soluble form of AZE was obtained by forming an inclusion complex of AZE with 2-hydroxypropyl β-cyclodextrin (HβC). In addition, the gel formulation, which generally exhibits higher permeability properties than oily formulations, was prepared using hydroxypropyl methylcellulose (HPMC). The formation of the inclusion complex was confirmed by NMR, XRD, DSC, and FTIR analyses. As a result of the characterization studies of the hydrogel formulations, it was determined that they had pseudoplastic flow and their viscosity was approximately 220 Pa.s. In drug release studies conducted with the dialysis bag method, it was found that the AZE-HβC hydrogel formulations had a similar cumulative release percent as HβC-free hydrogels but showed a higher cumulative release percent than the commercial cream (Azelderm, Orva, Türkiye). It was proven that the drug release of the formulations that exhibit a release profile in accordance with Higuchi kinetics was different from Azelderm according to difference (f1) and similarity (f2) factors.

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Section: Ftir Analysismentioning

confidence: 93%

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Davut ARPA,

DOĞAN,

GÜNDÜZ

et al. 2024

jrp

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“…In addition, whether there was a similarity between the release characteristics of the formulations was determined by the f2 similarity factor. f2>50 was evaluated being similarity of the DPH release profiles (Arpa et al, 2021).…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Preparation of Diatomite-Chitosan Composites for Loading and Release of Diphenhydramine HCl

ÖZKAN,

ARPA,

ÖZÇATAL

et al. 2023

Journal of Materials and Mechatronics: A

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Diatomite ores have great potential as an adsorbent and drug carrier system due to their natural abundance, biocompatible, and high surface area. In the first stage of this study, raw diatomite ore was enriched by grinding and calcination processes. As a result of the enrichment process, the surface area was found to be 21.7 m2/g for raw diatomite and 75.1 m2/g for calcined diatomite. Subsequently, a series of diatomite-chitosan composites with different composition ratios were produced. Then, the loading (adsorption) performances of diphenhydramine hydrochloride (DPH), an antihistaminic agent, were investigated on the prepared composites. The highest loading capacity was 91.1 mg/g, and the lowest loading capacity was 48.8 mg/g in the prepared DPH-loaded formulations. After DPH loading studies, DPH release profiles (desorption) and release kinetics from composites were investigated. As a result of in vitro release studies, it was observed that formulations containing chitosan polymer had slower release than chitosan free formulations. It was determined that the formulations had a cumulative release in the 70-90% range, and the release processes were completed between 45-90 minutes. In vitro release profiles of the prepared formulations were compatible with Higuchi kinetics.

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“…To obtain a better dispersion and fixation/catching of AgNPs in the HPMC matrix, the poly(N-vinylpyrrolidone) (PVP) has attracted considerable attention because it acts not only as a stabilizing agent but also has an impact on the control of the reduction rate of the silver ions and the aggregation process of silver atoms [ 41 , 42 ]. It is known to have excellent chemical and physical properties that make it a good material as additive or coating to other materials, including HPMC [ 43 , 44 , 45 , 46 ]. Thus, the utilization of PVP as a stabilizer facilitates the binding of the metal, leading to the improvement of the biomedical properties.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological Characterization and Antimicrobial Testing

Filimon¹,

Onofrei²,

Bargan³

et al. 2023

Polymers

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The progress achieved in recent years in the biomedical field justifies the objective evaluation of new techniques and materials obtained by using silver in different forms as metallic silver, silver salts, and nanoparticles. Thus, the antibacterial, antiviral, antifungal, antioxidant, and anti-inflammatory activity of silver nanoparticles (AgNPs) confers to newly obtained materials characteristics that make them ideal candidates in a wide spectrum of applications. In the present study, the use of hydroxypropyl methyl cellulose (HPMC) in the new formulation, by embedding AgNPs with antibacterial activity, using poly(N-vinylpyrrolidone) (PVP) as a stabilizing agent was investigated. AgNPs were incorporated in HPMC solutions, by thermal reduction of silver ions to silver nanoparticles, using PVP as a stabilizer; a technique that ensures the efficiency and selectivity of the obtained materials. The rheological properties, morphology, in vitro antimicrobial activity, and stability/catching of Ag nanoparticles in resulting HPMC/PVP-AgNPs materials were evaluated. The obtained rheological parameters highlight the multifunctional roles of PVP, focusing on the stabilizing effect of new formulations but also the optimization of some properties of the studied materials. The silver amount was quantified using the spectroscopy techniques (energy-dispersive X-ray fluorescence (XRF), energy-dispersive X-ray spectroscopy (EDX)), while formation of the AgNPs was confirmed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Also, the morphological examination (Atomic Force Microscopy (AFM) and Scanning electron microscopy (SEM)) by means of the texture roughness parameters has evidenced favorable characteristics for targeted applications. Antibacterial activity was tested against Escherichia coli and Staphylococcus aureus and was found to be substantially improved was silver was added in the studied systems.

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Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films

Cited by 5 publications

References 0 publications

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne

Preparation of Diatomite-Chitosan Composites for Loading and Release of Diphenhydramine HCl

Bioactive Materials Based on Hydroxypropyl Methylcellulose and Silver Nanoparticles: Structural-Morphological Characterization and Antimicrobial Testing

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