Formulation, Characterization, and Pharmacokinetic Studies of 6-Gingerol-Loaded Nanostructured Lipid Carriers

Wei, Qiuyu; Yang, Qiuxuan; Wang, Qilong; Sun, Congyong; Zhu, Yuan; Niu, Youhong; Yu, Jiangnan; Xu, Ximing

doi:10.1208/s12249-018-1165-2

Cited by 54 publications

(26 citation statements)

References 44 publications

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“…130 Wei et al demonstrated that nanostructured lipid carriers could be efficient in improving the water solubility of 6G, while sustaining its drug release, prolonging in vivo action time, and enhancing the drug oral bioavailability. 131 In addition, Zhen et al indicated that a polymeric micelle of 6G can increase oral bioavailability with enhanced brain distribution. 132 Overall, these studies showed the importance of ginger-derived nanoparticles in improved solubility and bioavailability.…”

Section: Ginger Delivery Systemsmentioning

confidence: 99%

Ginger: A complementary approach for management of cardiovascular diseases

et al. 2021

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Inflammation and oxidative stress play critical roles in progression of various types of CVD. Broad pharmacological properties of ginger (the rhizome of Zingiber officinale) and its bioactive components have been reported, suggesting that they can be a therapeutic choice for clinical use. Consistent with its rich phenolic content, the anti-inflammatory and antioxidant properties of ginger have been confirmed in many studies. Ginger modifies many cellular processes and in particular was shown to have potent inhibitory effects against nuclear factor kappa B (NF-κB); signal transducer and activator of transcription; NOD-, LRR-, and pyrin domain-containing proteins; toll-like receptors; mitogenactivated protein kinase; and mammalian target of rapamycin signaling pathways. Ginger also blocks pro-inflammatory cytokines and the activation of the immune system. Ginger suppresses the activity of oxidative molecules such as

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Section: Ginger Delivery Systemsmentioning

confidence: 99%

Ginger: A complementary approach for management of cardiovascular diseases

et al. 2021

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“…Also noteworthy the NLC loaded with orcinol-glycoside coated with PEG, a nanoformulation with potential for oral delivery, which showed anticancer activity against gastrointestinal cancer cell lines and hepatoma [36]. A final example in this section is the 6-Gingerol-loaded NLCs, which improved the water solubility and the oral bioavailability of the bioactive 6-gingerol, which presents poor water solubility [37].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

et al. 2019

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Many therapeutically active molecules are non-soluble in aqueous systems, chemically and biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. LBNPs advantages include high temporal and thermal stability, high loading capacity, ease of preparation, low production costs, and large-scale industrial production since they can be prepared from natural sources. Moreover, the association of chemotherapeutic agents with lipid nanoparticles reduces active therapeutic dose and toxicity, decreases drug resistance and increases drug levels in tumor tissue by decreasing them in healthy tissue. LBNPs have been extensively assayed in in vitro cancer therapy but also in vivo, with promising results in some clinical trials. This review summarizes the types of LBNPs that have been developed in recent years and the main results when applied in cancer treatment, including essential assays in patients.

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“…It has been described that gingerol has low solubility in water, leading to low bioavailability and limited applications. Several strategies may be employed to overcome these drawbacks, such as proliposomes [147], nanostructured lipid carriers [148] or microemulsion [149], achieving higher bioavailability and activity, compared to free gingerol.…”

Section: Gingerolmentioning

confidence: 99%

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies.

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Formulation, Characterization, and Pharmacokinetic Studies of 6-Gingerol-Loaded Nanostructured Lipid Carriers

Cited by 54 publications

References 44 publications

Ginger: A complementary approach for management of cardiovascular diseases

Ginger: A complementary approach for management of cardiovascular diseases

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

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