Formulation, characterization, in vitro, in vivo, and histopathological evaluation of transdermal drug delivery containing norfloxacin and Curcuma longa

Dua, Kamal; Chakravarthi, Srikumar; Kumar, Dinesh; Sheshala, Ravi

doi:10.4103/2230-973x.121287

Cited by 15 publications

(5 citation statements)

References 8 publications

(14 reference statements)

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“…Furthermore, good spreadability of F13 formula compared to F1 and F11 can be a probable cause for better killing activity since spreadability directly affects therapeutic efficacy of the drug. The present results were consistent with previously reported work done by Dua et al [54]. They found that Carbopol (C934) gel-based formulations exhibited better antibacterial activity against P. aeruginosa , S. aureus , and E. coli in comparison to other dermatological base formulations, indicating better activity of the drug.…”

Section: Resultssupporting

confidence: 93%

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Zakaria

Afifi

Elkhodairy

2016

BioMed Research International

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In an attempt to reach better treatment of skin infections, gel formulations containing Cefotaxime (CTX) were prepared. The gel was formulated using Carbopol 934 (C934), Hydroxypropyl Methylcellulose 4000 (HPMC 4000), Carboxymethylcellulose Sodium (Na CMC), Pectin (PEC), Xanthan Gum (XG), or Guar Gum (GG). Thirteen different formulas were prepared and characterized physically in terms of color, syneresis, spreadability, pH, drug content, and rheological properties. Drug-excipients compatibility studies were confirmed by FTIR and then in vitro drug release study was conducted. In vitro and in vivo antibacterial activities of CTX were studied against wound pathogens such as, Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa), using either pure drug or Fucidin® cream as control. F13 provides better spreadability compared to F1 (XG) or F11 (HPMC). Moreover, the release of the drug from hydrogel F13 containing C934 was slower and sustained for 8 h. Stability study revealed that, upon storage, there were no significant changes in pH, drug content, and viscosity of the gels. Also, F13 showed the larger inhibition zone and highest antibacterial activity among other formulations. Histological analysis demonstrated that after single treatment with F13 gel formulation, a noticeable reduction in microbial bioburden occurred in case of both Gram positive and Gram negative bacterial isolates.

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Section: Resultssupporting

confidence: 93%

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Zakaria

Afifi

Elkhodairy

2016

BioMed Research International

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“…In this research, we discovered that the wogonin therapy group had considerably reduced lipid peroxides, greater GSH, and enhanced antioxidant enzyme activity such as SOD and CAT that could decrease or stop ROS from forming. Therefore, our findings stated that the suppression of the pathological state of arthritis by antioxidant could be one mechanism of Wogonin in CFA rats …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, our findings stated that the suppression of the pathological state of arthritis by antioxidant could be one mechanism of Wogonin in CFA rats. [39][40][41][42] Several investigations disclosed that inflammatory processes played a significant part in RA pathogenesis. An amount of cytokines were demonstrated, such as IL-1β, IL-10, and TNF-α during inflammatory procedures guided the mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway

Huang¹,

Guo

Chitti³

et al. 2019

BioFactors

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Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with proliferative and damaging synovitis, resulting in joint death and cartilage and bone erosion. This study focused on the potential therapeutic effect of wogonin on complete Freund's adjuvant (CFA) induced RA in rats and the underlying mechanisms. Arthritis was experimentally caused in rats by subcutaneously injecting 0.1 mL of CFA into the subplantar area of the left hind paw under moderate anesthesia on day zero. The regular oral doses of indomethacin/wogonin began on day zero and proceeded after injection to day 35. Wogonin reduced arthritic score considerably, enhanced body weight, and reduced paw thickness. Wogonin also boosted red blood cell considerably along with hemoglobin and reduced white blood cell count and erythrocyte sedimentation rate. Wogonin substantially improved an altered level of oxidative stress markers, antioxidant proteins, and inflammatory cytokines in a dose‐dependent way. Wogonin inhibited p38 phosphorylation triggered by CFA and p65 nuclear translocation.

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“…The condition of hyperinsulinemia may lead to an increase in the level of Hcy as well as elevate blood pressure through various mechanisms. On the contrary, factors like dietary habits also contribute to insulin resistance . In summary, metabolic disturbances and long‐term hyperhomocysteinemia together with vascular remodeling suggested that enhanced oxidative stress, endothelium dysfunction, and decreased PPAR γ expression in the vessel wall could be underlying mechanisms for hyperhomocysteinemia‐associated hypertension .…”

Section: Metabolism Of Homocysteinementioning

confidence: 99%

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

Singh¹,

Samuel

Dahiya

et al. 2019

Biotech and App Biochem

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Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy) is a sulfur‐containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta‐analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin‐converting enzyme inhibitors angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia‐associated hypertension.

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Formulation, characterization, in vitro, in vivo, and histopathological evaluation of transdermal drug delivery containing norfloxacin and Curcuma longa

Cited by 15 publications

References 8 publications

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Newly Developed Topical Cefotaxime Sodium Hydrogels: Antibacterial Activity andIn VivoEvaluation

Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

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