Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box–Behnken statistical design

Salem, Heba F.; Kharshoum, Rasha M; Sayed, Ossama M.; Hakim, Lekaa F Abdel

doi:10.1080/03639045.2018.1504963

Cited by 67 publications

(39 citation statements)

References 35 publications

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“…Glycerosomes can be prepared using the same methods that are used for the preparation of conventional liposomes [2,23] . However, researchers have mostly used thin film hydration method for the preparation of glycerosomes [23,28,49] . The various methods of preparation according to the vesicle lamellarity are listed below:…”

Section: Of Preparation Of Glycerosomesmentioning

confidence: 99%

“…Particle size analysis and polydispersity index (PI) of glycerosome preparation can be tested on a zetasizer. This process is known as dynamic laser light scattering [27,30] or photon correlation spectroscopy [22,23,28,49] . Usually a Malvern zetasizer is used for this purpose [22,23,28,49] .…”

Section: Parameters Of Glycerosomes Particle Size Analysismentioning

confidence: 99%

“…When all the samples have been administered then the skin is detached from Franz diffusion cell. After separating epidermis from dermis, the layers are then sonicated and the amount of drug determined [22,23,28,49] .…”

Section: Determination Of Penetrationmentioning

confidence: 99%

“…In this procedure, 1 ml of glycerosome preparation is added to dialysis bag and the bag is immersed in phosphate buffer. Samples are taken out at definite intervals and analysed using a UV or a HPLC method [49] .…”

Section: Determination Of Drug Release In Vitromentioning

confidence: 99%

“…It was reported that diclofenac enhanced glycerol interaction with phospholipid bilayers as being amphipathic in nature and gets inserted in lipid bilayers and thus causes a reduction in transition temperature [23,28] . Salem et al reported the topical delivery of celecoxib and cupferron by formulating glycerosomes and its gel [49] . They used soybean phosphatidyl choline as the phospholipid.…”

Section: Determination Of Fluiditymentioning

confidence: 99%

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Glycerosomes: Advanced Liposomal Drug Delivery System

Gupta¹,

Mazumder²,

Padhi³

2020

Indian J Pharm Sci

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Gupta et al.: Glycerosomal Drug Delivery Systems Although liposomes have proved to be versatile in the field of drug delivery, there are still some issues that need to be addressed mainly problems related to entrapment, penetration, fluidity and stability. Glycerosomes represent a novel drug delivery systems composed of phospholipids, water and glycerol in varying amounts. Glycerosomes are upgraded versions of liposomes meant for topical and transdermal drug delivery. In these preparations, glycerol acts as an edge activator and penetration enhancer. These drug delivery systems manifest improved stability, fluidity, entrapment and penetration in comparison to conventional liposomes. Increasing the concentration of glycerol by 10, 20 or 30 % leads to a drastic increase in glycerosome stability. This article is a detailed review of glycerosomes focusing on methods of preparation, evaluation, applications, advantages and disadvantages based on studies reported so far. In this review article, how the structure of liposomes can be modified by the addition of glycerol and how this modified structure can be used to address the problems related to liposomes is discussed. The influence of increasing glycerol concentration on the nature of glycerosomes that lead to an increase in both entrapment and encapsulation of a drug while causing slower drug release is discussed.

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Section: Of Preparation Of Glycerosomesmentioning

confidence: 99%

Section: Parameters Of Glycerosomes Particle Size Analysismentioning

confidence: 99%

Section: Determination Of Penetrationmentioning

confidence: 99%

Section: Determination Of Drug Release In Vitromentioning

confidence: 99%

Section: Determination Of Fluiditymentioning

confidence: 99%

See 3 more Smart Citations

Glycerosomes: Advanced Liposomal Drug Delivery System

Gupta¹,

Mazumder²,

Padhi³

2020

Indian J Pharm Sci

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Pharmaceutical and clinical studies of celecoxib topical hydrogel for management of chemotherapy-induced hand-foot syndrome

Shayeganmehr

Ramezannia

Gharib³

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Natamycin Ocular Delivery: Challenges and Advancements in Ocular Therapeutics

2023

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Fungal keratitis, an ocular fungal infection, is one of the leading causes of monocular blindness. Natamycin has long been considered the mainstay drug used for treating fungal keratitis and is the only US Food and Drug Administration (USFDA)-approved drug, commercially available as a topical 5% w/v suspension. Furthermore, ocular fungal infection treatment takes a few weeks to months to recover, and the available marketed antifungal suspensions are associated with poor residence time, limited bioavailability (< 5%) and high dosing frequency as well as minor irritation and discomfort. Despite these challenges, natamycin is still the preferred drug choice for treating fungal keratitis, as it has fewer side effects and less ocular toxicity and is more effective against Fusarium species than other antifungal agents. Several novel therapeutic approaches for the topical delivery of natamycin have been reported to overcome the challenges posed by the conventional dosage forms and to improve ocular bioavailability for the efficient management of fungal keratitis. Current progress in the delivery systems uses approaches aimed at improving the corneal residence time, bioavailability and antifungal potency, thereby reducing the dose and dosing frequency of natamycin. In this review, we discuss the various strategies explored to overcome the challenges present in ocular drug delivery of natamycin and improve its bioavailability for ocular therapeutics.

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Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box–Behnken statistical design

Abstract: Finally, the administration of CLX2* and CUP1* loaded glycerosomal gel onto the skin resulted in marked reduction of edema, congestive capillary and inflammatory cells and this approach may be of value in the treatment of different inflammatory disorders.

Cited by 67 publications

References 35 publications

Glycerosomes: Advanced Liposomal Drug Delivery System

Glycerosomes: Advanced Liposomal Drug Delivery System

Pharmaceutical and clinical studies of celecoxib topical hydrogel for management of chemotherapy-induced hand-foot syndrome

Natamycin Ocular Delivery: Challenges and Advancements in Ocular Therapeutics

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