Formulation, Development and Evaluation of Nano Ethosomal Gel of Tramadol Hydrochloride

Abstract

Step 3: Add Solution A to Solution B under ultra-shear homogenization and continue ultra-shear homogenization at speed 6000 rpm for 30 min.Step 4: Add purified water under ultra-shear homogenization drop wise in the centre of the container. The dispersion is further homogenized for 15 min at room temperature with homogenization speed 6000 rpm.Step 5: Formulated Ethosomes forms the cloudy homogenous liquid. The Ethosomes were stored at temperature 4°C ± 0.5°C for further evaluation (Table 1) [3,7-9]. Preparation of gel:Step 1: Ethosomes equivalent to 1% of Tramadol HCl is calculated. AbstractTopical administration of drugrs is better for local action and the efficiency of the topically administered drug is increased with Liposome, proliposomes and ethosomes. Tramadol HCl has used the local anaesthetic. Ethosomes were formulated using soya lecithin, cholesterol, ethanol and purified water using ultra shear homogenizer. Ethosomes were evaluated for vesicle size, shape, optical microscopy and in-vitro release study. FS05 and FC05 have better drug release profile than the other formulation. The ethosomes were entrapped in gel matrix of carbopol 980 in different concentration 0.75%, 1.00%, 1.25% and 1.50% w/w. The formulated gel formulation were evaluated with parameter drug content, pH, viscosity, spreadability, in-vitro release test, and ex-vivo study. The formulation FS05 C03 and FC05 C03 have better in-vitro and ex-vivo drug release profile which contains Carbopol 980 concentration 1.25%w/w. Both the formulation FS05 C03 and FC05 C03 were stable for 3 Months at room temperature and accelerated storage condition. The 3 M stability sample of FS05 C03 has maintained the drug release profile but the drug release profile of formulation FC05 C03 has dropped significantly.

Role of Drug Repurposing in Cancer Treatment and Liposomal Approach of Drug Targeting

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Formulation and In-vitro Evaluation of Ethosomal Gel of Repaglinide for Transdermal Delivery

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Efficacy of Transdermal Delivery Nano Ethosomal Gel from Ashitaba Leaves on In-vivo Burn Wound Healing in Albino Rats

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