Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum

Prakash, K. Vanitha; Satyanarayana, Varanasim; Nagiat, Hwisat; Assaleh, Fathi H.; Adiki, Shanta Kumari; Prameela, Avular

doi:10.4103/0973-8398.143937

Cited by 31 publications

(15 citation statements)

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“…e results in Figure 1 show apple jelly samples had shear-thinning behaviors. e same results about shear-thinning behaviors of jelly were reported by Prakash et al [31] and Figueroa and Genovese [21]. High molecular weight, the aggregated state, and hydrogen bonds between polymer chains are mainly responsible for the shear-thinning behavior of polysaccharides [32].…”

Section: Viscosity Propertiessupporting

confidence: 77%

“…e apparent viscosity of P50G50, P75G25, P25G75, P100, and G100 at the shear rate of 19.1 s −1 and 25°C was 3161.80, 3519.80, 2296.30, 13222, and 189.99 MPa•s, respectively. Prakash et al [31] reported that a combination of guar gum and pectin had higher effects on the viscosity of jellies. Also, they reported that higher viscosity is a suitable property in the jelly formulations.…”

Section: Viscosity Propertiesmentioning

confidence: 99%

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The Effects of Gum Cordia on the Physicochemical, Textural, Rheological, Microstructural, and Sensorial Properties of Apple Jelly

Hasani

Yazdanpanah

2020

Journal of Food Quality

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The aim of this research was to study the effects of gum cordia on the physicochemical, color, textural, rheological, microstructural, and sensorial properties of apple jelly. Apple jelly was prepared by replacement of 0, 25, 50, 75, and 100% of pectin with gum cordia. The results showed that gum cordia had a significant effect on the physicochemical properties (ash, protein, TPC, DE, and color) of apple jelly. The total phenol content of the sample significantly increased with the addition of gums. The rheological properties showed that a sample containing 75% gum cordia was similar to control and had the highest apparent viscosity, loss moduli (G″), storage moduli (G′), and complex viscosity. Also, the sensorial properties showed that a sample containing 75% gum cordia had a high score in texture, taste, appearance, and overall acceptability. The results suggested that gum cordia as a polymer can be successfully employed for the formulation of jelly for improving technofunctional properties of jelly.

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Section: Viscosity Propertiessupporting

confidence: 77%

Section: Viscosity Propertiesmentioning

confidence: 99%

The Effects of Gum Cordia on the Physicochemical, Textural, Rheological, Microstructural, and Sensorial Properties of Apple Jelly

Hasani

Yazdanpanah

2020

Journal of Food Quality

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“…Owing to its non-toxicity, biodegradability, bioavailability and biocompatibility guar gum and its derivatives are widely studied for various therapeutic applications such as drug delivery. It is a potential material for oral drug delivery systems having stability over wide pH range, also it is prone to enzymes exuded from colonic microflora in the colon (98)(99)(100)(101). It has a considerable number of hydroxyl groups in the backbone, it shows high solubility in water which thwarts its biomedical applications.…”

Section: Guar Gum (Gg)mentioning

confidence: 99%

A glimpse of biodegradable polymers and their biomedical applications

Shah

Vasava

2019

E-Polymers

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Over the past two decades, biodegradable polymers (BPs) have been widely used in biomedical applications such as drug carrier, gene delivery, tissue engineering, diagnosis, medical devices, and antibacterial/antifouling biomaterials. This can be attributed to numerous factors such as chemical, mechanical and physiochemical properties of BPs, their improved processibility, functionality and sensitivity towards stimuli. The present review intended to highlight main results of research on advances and improvements in terms of synthesis, physical properties, stimuli response, and/or applicability of biodegradable plastics (BPs) during last two decades, and its biomedical applications. Recent literature relevant to this study has been cited and their developing trends and challenges of BPs have also been discussed.

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“…Oral gel is a fundamental solution for dysphagic patients and is frequently prescribed for geriatrics [25,26]. The gel has the advantage of preventing precipitation due high viscosity.…”

Section: Introductionmentioning

confidence: 99%

“…Gel formulations can be designed for immediate release or sustained release [28]. One study described a CBZ oral gel and performed a comparison study between different gelling agents and a stability study for those gelling agents, but the release was almost completed in 1 h (immediate release dosage form) [25,26]. There is no existing report on a sustained release gel formulation for CBZ.…”

Section: Introductionmentioning

confidence: 99%

Carbamazepine Gel Formulation as a Sustained Release Epilepsy Medication for Pediatric Use

et al. 2019

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This study aimed to develop a carbamazepine (CBZ) sustained release formulation suitable for pediatric use with a lower risk of precipitation. The CBZ was first prepared as sustained release microparticles, and then the microparticles were embedded in alginate beads, and finally, the beads were suspended in a gel vehicle. The microparticles were prepared by a solvent evaporation method utilizing ethyl cellulose as a sustained release polymer and were evaluated for particle size, encapsulation efficiency, and release profile. The beads were fabricated by the dropwise addition of sodium alginate in calcium chloride solution and characterized for size, shape, and release properties. The gel was prepared using iota carrageenan as the gelling agent and evaluated for appearance, syneresis, drug content uniformity, rheology, release profile, and stability. The microparticles exhibited a particle size of 135.01 ± 0.61 µm with a monodisperse distribution and an encapsulation efficiency of 83.89 ± 3.98%. The beads were monodispersed with an average size of 1.4 ± 0.05 mm and a sphericity factor of less than 0.05. The gel was prepared using a 1:1 ratio (gel vehicle to beads) and exhibited no syneresis, good homogeneity, and good shear-thinning properties. The release profile from the beads and from the gel was not significantly affected, maintaining similarity to the tablet form. The gel properties were maintained for one month real time stability, but the accelerated stability showed reduced viscosity and pH with time. In conclusion, CBZ in a gel sustained release dosage form combines the advantages of the suspension form in terms of dosing flexibility, and the advantages of the tablet form in regards to the sustained release profile. This dosage form should be further investigated in vivo in animal models before being considered in clinical trials.

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Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum

Cited by 31 publications

References 1 publication

The Effects of Gum Cordia on the Physicochemical, Textural, Rheological, Microstructural, and Sensorial Properties of Apple Jelly

The Effects of Gum Cordia on the Physicochemical, Textural, Rheological, Microstructural, and Sensorial Properties of Apple Jelly

A glimpse of biodegradable polymers and their biomedical applications

Carbamazepine Gel Formulation as a Sustained Release Epilepsy Medication for Pediatric Use

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