Formulation Development and Evaluation of Desloratadine Sugar Free Oral Liquid Dosage Form

Abstract

The aim of the present work is to formulate and evaluate Desloratadine Sugar free oral liquid dosage form. Desloratadine is an anti-histamine drug which is used to treat allergic reactions such as chronic utricaria, watery eyes and runny nose. In this Present work Desloratadine sugar free oral liquid dosage form was formulated by using artificial sweeteners with the help of simple mixing technique and subjected to various evaluation tests. The Pre-formulation studies like identification of pure drug by melting point method, solubility, Drug-Excipients compatibility studies by FTIR studies were evaluated. Post formulation studies like oranganoleptic properties, Physico-chemical properties, Assay, Related substances and Microbial examination were evaluated. Organoleptic property has shown that the all formulations was found to be clear orange and complies with innovator. Assay of Desloratadine and sodium benzoate of all six formulations F1, F2, F3, F4, F5, and F6 were determined and found to be 99.1%, 99.8%, 100.1%, 100.2%, 100.1% and 99.9% respectively. Related substances of all the formulations were determined and the impurities A and B were found to be within the limits and there is no any unspecified impurity. Microbial examinations of all the formulations are determined and the total bacterial count and fungal count are within the limits and E.coli is absent. The formulation of Desloratadine sugar free oral liquid dosage form by using artificial sweeteners was Developed and evaluated.