Formulation Development And Evaluation Of Aegle Marmelos Polysaccharide As a Matrix Former

Abstract

Background- The goal of the whole study was to examine the formulation of tablets containing sustained-release metoprolol succinate employing Aegle marmelose (Bael), a member of the Rutaceae family, as the matrix forming polymer. Excipients play an important function in enhancing a formulation's quality. Result-The use of aegle marmelose polymers in pharmacy is similar to that of synthetic polymers, which have a wide range of potential applications in innovative drug delivery systems as matrix formers. Due to the fact that these polysaccharide gums are naturally plentiful, biocompatible, biodegradable, and non-immunogenic, and because they boost the economy by giving people access to low-cost formulations made using locally accessible materials. In order to get the desired features of components for drug delivery systems, they can also be altered in a variety of ways, which makes them competitive with the synthetic additives that are now available. The formulation of metoprolol succinate matrix tablets uses the fruits of the Aegle marmelosto as a binder. The metoprolol succinate tablet was created using a 32 factorial design (F1 to F9), and from that F6 batch, tablets were tested for weight variation, hardness, friability, drug content, drug release research, stability study, solubility study, swelling property, and drug excipients compatibility.. Conclusion-Metoprolol succinate tablets that have been manufactured and tested for stability reveal no major alterations, making aegel marmalos polysaccharide a more suitable natural binder than synthetic one Additionally, the goal of the study was to determine the potential of natural polysaccharide.