Formulation Development and Ex-Vivo Permeability of Curcumin Hydrogels under the Influence of Natural Chemical Enhancers

Abstract

Background: The aim of the present research was to formulate and evaluate curcumin hydrogel and to investigate the potential of natural essential oils as permeation enhancers. Methods: Curcumin 2% w/w hydrogel containing various concentrations of eucalyptus oil, aloe vera oil and clove oil was developed using carboxy methyl cellulose (CMC) as a gelling agent. Differential scanning calorimetry and Fourier Transform infrared spectroscopy were used to evaluate the compatibility between the drug and the excipients. In order to assess the efficacy of the formulation; rheological properties, skin irritation studies, in vitro release, ex vivo permeation and retention studies were conducted. Results: DSC and FTIR suggest no in-compatibility between curcumin and excipients. Studies proved that addition of suitable natural permeation enhancers to the hydrogels improved the in vitro release and ex vivo permeation and retention of curcumin. From the various natural essential oils, the aloe vera oil at a concentration of 3% w/w had the greatest effect on the permeability rate and skin retention of the Curcumin and produces the highest enhancement ratio amongst all the concentrations of essential oils examined. Conclusion: Aloe vera oil enhances the permeation of curcumin across the skin by altering the complex structure of the stratum corneum without itself undergoing any change. The developed curcumin hydrogels along with natural essential oils may present an effective choice regarding skin infection/wound healing.

Preparation and In Vitro Evaluation of Controlled-Release Matrices of Losartan Potassium Using Ethocel Grade 10 and Carbopol 934P NF as Rate-Controlling Polymers

“…The drug release pattern is a pivotal aspect, especially when applied to formulations for oral administration since it allows for fine temporal control of the drug circulation in the human or animal host, thus tuning its therapeutic effects and preventing some of the potential adverse effects [ 20 ]. Polymers are widely recognized as the most effective molecules associated with drugs for preparing controlled-release formulations, and the appropriate polymer selection is crucial for optimizing the drug encapsulation, dissolution, and, consequently, activity [ 21 ].…”

Formulation and Characterization of Ethyl Cellulose-Based Patches Containing Curcumin-Chitosan Nanoparticles for the Possible Management of Inflammation via Skin Delivery

“…Hence, 2 mL aliquots were taken at specified time intervals, i.e., 0.5, 1, 1.5, 2, 4, 8, 12, 16, and 24 h, respectively, and replaced with fresh buffer in order to maintain sink condition. The samples were analyzed using a UV visible spectrophotometer at 425 nm wave length [ 32 ].…”

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

“…The biocompatibility, swelling behavior, and low toxicity of hydrogels make them suitable candidates for biomedical applications including drug delivery. − One of the major obstacles for drug development is the administration of hydrophobic drugs with low solubility in aqueous media . Considering the unique properties of hydrogels, this delivery system can be used as a promising vehicle for formulation of low soluble hydrophobic therapeutics. ,, This approach enables researchers and patients to apply these therapeutic agents via oral, topical or parenteral routes of administration …”