Formulation Development and Optimization of Famotidine Mucoadhesive Tablets by Central Composite Design

Chinthaginjala, Haranath; Telkar, Mousami Bhavasar; Hindustan, Abdul Ahad; Pradeepkumar, Bhupalam

doi:10.5530/ijper.56.4.185

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…The mean of three trials was calculated for each set of formulations to ensure reliable results. To ensure consistent outcomes for the formulation, the tissue was precisely rinsed with phosphate buffer after each measurement, with a 5-minute interval before introducing a fresh film 32, 33 .After calculating the mucoadhesion strength, the adhesion force was determined using the provided equations (Eq.4) 34 .…”

Section: Mucoadhesion Strengthmentioning

confidence: 99%

Formulation and Evaluation of Linagliptin Buccal Films

Doijode,

Mahalingan,

Abdul Ahad

et al. 2024

Int J Life Sci Pharm Res

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Achieving steady concentration levels of drugs in the plasma for diabetics is important for an extended period. Thestudy focussed on developing mucoadhesive buccal films incorporating linagliptin, aiming to achieve controlled drug delivery foreffective type 2 diabetes management towards steady level plasma concentration. The research utilizes various mucoadhesivepolymers, specifically HPMC K100, HPMC E5LV, and Eudragit RL100, exploring their potential in formulating optimized filmsthrough solvent casting technique. Our primary aim was to identify the most effective formulation, that would ensure controlleddrug release over an extended period. We formulated various formulations and evaluated drug content, swelling index, in-vitrodrug discharge, and ex-vivo mucoadhesive strength. The formulation, incorporated linagliptin, HPMC E5LV, HPMC K100,Eudragit RL100, glycerol, and polyethylene glycol. Results from our comprehensive evaluations showcased favorable dissolutiontime, robust mechanical properties, and impressive mucoadhesive characteristics in the buccal films. The sustained drugdischarge and mucoadhesive strength exhibited by formulation F7 indicate its potential for effective type 2 diabetes managementwith a single film administration lasting up to 8 hours. This research represents a significant step forward in the field ofpharmaceuticals, offering a promising avenue for developing mucoadhesive buccal films to control drug delivery precisely forenhanced therapeutic outcomes in the management of type 2 diabetes.

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Section: Mucoadhesion Strengthmentioning

confidence: 99%

Formulation and Evaluation of Linagliptin Buccal Films

Doijode,

Mahalingan,

Abdul Ahad

et al. 2024

Int J Life Sci Pharm Res

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“…A Full factorial experimental design of nine formulations was set up, using two factors at three levels. 9 The independent variables used were numeric factors namely, X1-concentration of Carbopol 934 and X2-concentration of HPMC K15. The responses selected for statistical optimization were, Y1-Mucoadhesive strength and Y2-% Drug permeated after 8hr showed in…”

Section: Experimental Designmentioning

confidence: 99%

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

PB Suruse,

MB Gawali,

RS Kalkotwar

et al. 2023

Ind. J. Pharm. Edu. Res

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Objectives:The aim of the study was to design, develop, and optimize the buccal tablets containing extract of Terminalia chebula Retz. for the treatment of asthma. Materials and Methods: Buccal tablets were made using the direct compression method, and screening tests with various polymers were run to see how they affected the properties of the tablets. The utilisation of response surface methods, two polymer types, carbopol® and HPMC, were chosen for additional optimization research. Strength of mucoadhesion and % two significant responses that the drug permeated after 8 hr from the buccal mucosa were chosen. By using a swelling index analysis, the profiles and kinetics of in vitro drug release were examined. Results:The Terminalia chebula Retz. content in buccal tablets was determined to be 99.14±0.44%, and a DSC analysis showed that there was no chemical interaction between the ingredients of the tablet (8 g carbopol 934 and 20 g HPMC K15 made up the optimal formulation). After 8 hr of in vitro dissolving studies, a cumulative Terminalia chebula Retz. release of 90% was reached, which was confirmed by swelling analysis. Conclusion: The findings suggested that Terminalia chebula Retz's. optimised buccal tablets would be a promising and different delivery method for the treatment of asthma.

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“…Central Composite Design (CCD) is a statistical method availed in the optimization of formulations. 5 The application of CCD during the design and development process could simultaneously determine the interactive effect of different variables that influence the results/quality of products. CCD involves statistical techniques and mathematical methods for building an experimental design model based on fitted polynomial equations with experimental data.…”

Section: Introductionmentioning

confidence: 99%

Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

Chinthaginjala,

Ahad,

Kethandapatti Srinivasa

et al. 2023

Ind. J. Pharm. Edu. Res

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Objectives:The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was employed to prepare the tablets. Drug -excipient studies were executed through FT-IR and DSC analysis. The independent variables selected were the concentrations of Carbopol 934 (X 1 ) and HPMC K15M (X 2 ). The dependent variables designated were Floating Lag Time (FLT) and Drug Release (DR) at 12 hr. The model was found to be nonlinear and the curvature effect was significant. Hence, the system suggested to central composite design. Results: FT-IR studies demonstrated that there is no considerable interaction amid the drug and the excipients. DSC studies revealed that drug and excipient were compatible as there is no significant alteration in melting point of drug when blended with excipients. The precompression parameters of the formulations showed good flow properties. The evaluation of post compression parameters indicated that all the prepared formulations were within the specified limits. Floating lag time of formulations were marked to be less than 1 min and total floating time exceeding 12 hr. Percentage drug release of all formulations were in the range of 89.7% to 99.4%. The obtained design space/contour plots were used for selecting batches in desirable ranges. Conclusion: The results revealed that experimental design was successfully used to optimize polymer concentrations. It was determined that the central composite design would be used to formulate dextromethorphan gastroretentive floating tablets with fewer trials and higher quality features.

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Formulation Development and Optimization of Famotidine Mucoadhesive Tablets by Central Composite Design

Cited by 5 publications

References 5 publications

Formulation and Evaluation of Linagliptin Buccal Films

Formulation and Evaluation of Linagliptin Buccal Films

Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

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