Formulation, in vitro Characterization and Stability Studies of Fast Dispersing Tablets of Diclofenac Sodium

Abstract

The present study was aimed to formulate, develop and evaluate the fast dissolving tablets of diclofenac sodium, used for the treatment of arthritis, inflammation, pain. Fast dissolving tablets of diclofenac sodium were prepared by direct compression method using crospovidone and sodium starch glycolate as superdisintegrants in concentrations of 5.3%, 6.6% and 8% w/w and in combination. In this work microcrystalline cellulose and mannitol are investigated as diluents. Prepared powder mixtures were evaluated for drug excipient compatibility with FTIR spectroscopy and DSC analysis. Prepared formulations are evaluated for In vitro dissolution, disintegration dispersion and wetting time. Formulation FCS6 prepared with combination of crospovidone and sodium starch glycolate at weight ratio of 6.6 and 2.3% showed better results compare with control. Post compression parameters like hardness (3.4 kg/cm 2 ) and friability (0.31%) are at good acceptable levels in accordance with official compendia. FCS6 showed improved dissolution (99.8 %) and dispersion (75 seconds) profiles compared to control. The FTIR and DSC showed no interaction between the drug and excipients. The optimized formula FCS6 showed good drug release characteristics with acceptable mouth feel and fast dissolving properties.

Fabrication and Characterization of Diclofenac Sodium Loaded Hydrogels of Sodium Alginate as Sustained Release Carrier

“…COOH groups of DS indicate stretching vibrations at 3310 cm −1 , while peaks at 3430 cm −1 and 1654 cm −1 characterize the stretching vibrations of N–H and C=C, respectively. Swain et al (2015) reported the same peaks in their studies, which further support our studies [ 21 ]. The FTIR spectrum of SA ( Figure 2 B) indicates an extensive band at 3420 cm −1 due to OH groups of hydrogen bonding.…”

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

“…FTIR spectrum of DS ( Figure 2 A) indicates COOH-stretching vibrations at the peak 3340 cm −1 , while at peaks 1650 and 3480 cm −1 , C=C and N–H stretching are observed, correspondingly [ 24 ]. Swain et al (2015) reported the above peaks in his studies in the same range as in our studies [ 25 ].…”

Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers

“…The presence of carboxyl group is confirmed by the overlapping of two different functional groups, i.e., -OH and C-O at 1430 cm −1 and 1387 cm 1 respectively. Likewise, S=O stretching vibration of the sulfate group is detected at peak 1250 cm −1 [48,49]. Similarly, CBP FTIR spectra (Figure 5C) reveal stretching vibration of C=O, OH, and R-CH 2 at 1632, 2703, and 2998 cm −1 , respectively [50][51][52].…”