Formulation of Dexibuprofen Solid Lipid Nano Particles and Its Evaluation by in Vitro Dissolution Study

Abstract

Dexibuprofen is a poorly water soluble nonsteroidal anti-inflammatory drug, prescribed for moderate to severe pain and inflammation. It is the active dextrorotatory enantiomer of ibuprofen and has better anti-inflammatory effect. Hence present study was carried out to enhance dissolution properties of dexibuprofen through the preparation of solid lipid nano particles (SLNPs) using stearic acid as lipid, lutrol F-68 (Poloxamer) as surfactant and tween-80 as stabilizer by hot homogenization method. Six formulations were prepared in different ratios and were designated as DNP1 to DNP6. USP type II rotating paddle dissolution studies in 900 ml distilled water at 50 rpm to a temperature of 37°C ± 0.5°C were performed for evaluation of solid lipid nano particles. UV spectrophotometric method was selected for assay as well as in-vitro dissolution studies at λmax 222 nm. The drug release profile followed zero order and first order kinetics. In-vitro studies showed that solubility and dissolution rate of dexibuprofen were significantly improved by SLN formulation than the drug alone. This result may trigger more research in the intension of exploiting this feature to develop a novel drug delivery system for dexibuprofen with enhanced bioavailability.