Formulation of essential oils-loaded solid lipid nanoparticles-based chitosan/PVA hydrogels to control the growth of Botrytis cinerea and Penicillium expansum

Fincheira, Paola; Espinoza, Javier; Levío-Raimán, Marcela; Vera, Joelis; Tortella, Gonzalo; Brito, Adrianne Marlise Mendes; Seabra, Amedea B.; Diez, María Cristina; Quiroz, Andrés; Rubilar, Olga

doi:10.1016/j.ijbiomac.2024.132218

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.132218

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Formulation of essential oils-loaded solid lipid nanoparticles-based chitosan/PVA hydrogels to control the growth of Botrytis cinerea and Penicillium expansum

Paola Fincheira,

Javier Espinoza,

Marcela Levío-Raimán

et al.

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2024

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Cited by 3 publications

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New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

Lv,

Liu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Penicillium expansum is the major fungus that causes blue mold and produces patulin, threatening human health. Due to health and environmental pollution concerns, chitosan (CS) has attracted more and more attention as a safer alternative to synthetic fungicides for the control of blue mold. In the present study, four different benzimidazole groups were introduced onto CS by the acylation reaction to obtain benzimidazole-based chitosan derivatives (R1b−R4b). After being well-characterized with Fourier transform infrared spectroscopy (FTIR), ultraviolet−visible spectroscopy (UV−vis spectra), and nuclear magnetic resonance (NMR), their antifungal activities against P. expansum were screened. Results showed that the inhibitory effects of chitosan derivatives against the pathogen were significantly correlated with chitosan derivatives' concentration and their structures. R4b was shown as optimum with good solubility and antifungal activity with a minimum inhibitory concentration (MIC) value of 0.5 mg/mL and a minimum fungicidal concentration (MFC) value of 2.0 mg/mL. The remarkable antifungal efficiency of R4b against P. expansum was further demonstrated in terms of spore germination, mycelial growth, patulin production, and the preliminary antifungal mechanism. R4b exhibited significant inhibition of patulin production, while its antifungal mechanism was revealed by destroying cell membrane integrity and inducing membrane depolarization. Furthermore, R4b treatment could significantly reduce the incidence of blue mold rot in apple fruit, and the MTT assay showed the nontoxicity of R4b against Raw 264.7, HBZY-1, and Caco-2 cells. Altogether, these results indicate that it is promising to be used as a fruit preservative in the future.

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New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

Lv,

Liu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements

Fathi,

Machado,

de A. C. Kodel

et al. 2024

Expert Opinion on Drug Delivery

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Hydrogels with Essential Oils: Recent Advances in Designs and Applications

Chelu

2024

Gels

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The innovative fusion of essential oils with hydrogel engineering offers an optimistic perspective for the design and development of next-generation materials incorporating natural bioactive compounds. This review provides a comprehensive overview of the latest advances in the use of hydrogels containing essential oils for biomedical, dental, cosmetic, food, food packaging, and restoration of cultural heritage applications. Polymeric sources, methods of obtaining, cross-linking techniques, and functional properties of hydrogels are discussed. The unique characteristics of polymer hydrogels containing bioactive agents are highlighted. These include biocompatibility, nontoxicity, effective antibacterial activity, control of the sustained and prolonged release of active substances, optimal porosity, and outstanding cytocompatibility. Additionally, the specific characteristics and distinctive properties of essential oils are explored, along with their extraction and encapsulation methods. The advantages and disadvantages of these methods are also discussed. We have considered limitations due to volatility, solubility, environmental factors, and stability. The importance of loading essential oils in hydrogels, their stability, and biological activity is analyzed. This review highlights through an in-depth analysis, the recent innovations, challenges, and future prospects of hydrogels encapsulated with essential oils and their potential for multiple applications including biomedicine, dentistry, cosmetics, food, food packaging, and cultural heritage conservation.

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Formulation of essential oils-loaded solid lipid nanoparticles-based chitosan/PVA hydrogels to control the growth of Botrytis cinerea and Penicillium expansum

Cited by 3 publications

References 52 publications

New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

New Family of Benzimidazole-Based Chitosan Derivatives against Penicillium expansum

Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part II – applications and preclinical advancements

Hydrogels with Essential Oils: Recent Advances in Designs and Applications

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