Formulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P

Gopikrishna, Addanki; Ramu, B.; Srikanth, G.; Rajkamal, B.

doi:10.21477/ijapsr.v1i2.10177

Cited by 9 publications

(3 citation statements)

References 4 publications

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“…Drug release mechanisms were obtained by placing values of cumulative drug release rates into various mathematical models for drug release kinetics, such as zero-order, first-order, Hixon crowell’s [ 23 ], Highuchi [ 24 ], and power law models [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents

Khan

Muzammal

et al. 2022

Molecules

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Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method was adopted for the preparation of matrices. In phosphate buffer (pH 6.8), the dissolution study was conducted by adopting the USP method-I as the specified method. Drug release kinetics was determined and dissolution profiles were also compared with the reference standard. Prolonged release was observed for all matrices, but those with Ethocel 100FP Premium showed more extended release. The co-excipient (HPMC, CMC, and starch) exhibited enhancement in the drug release rates, while all controlled release matrices released the drug by anamolous non-Fickian diffusion mechanism. This combination of polymers (Ethocel grade 100 with Carbopol 934PNF) efficiently extended the drug release rates up to 24 h. It is suggested that these matrix tablets can be given in once a day dosage, which might improve patient compliance, and the polymeric blend of Ethocel grade 100 with Carbopol 934PNF might be used in the development of prolonged release matrices of other water-soluble drugs.

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Section: Methodsmentioning

confidence: 99%

Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents

Khan

Muzammal

et al. 2022

Molecules

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“…As a result, less water is reabsorbed from the collecting ducts, boosting urine output by increasing the osmolarity in the lumen. It is frequently used to treat hypertension, congestive heart failure, symptoms of edema, and to prevent kidney stones [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation of Propranolol and Hydrochlorothiazide

Golchha,

B.Rajkamal

2024

Preprint

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The active pharmaceutical components of Propranolol and Hydrochlorothiazide in their bulk dosage forms were to be measured using a unique, straightforward, responsive, and stable RP- HPLC method that was being developed and gradually validated. For the quantitative determination of Propranolol and Hydrochlorothiazide, a straightforward, specific, verified, and well-defined stability that exhibits gradient RP-HPLC approach has been developed. The Waters C18 column (150mm×4.6mm, 5mm particle size) was used for the chromatographic method, which involved isocratic elution with a mobile phase made up of orthophosphoric acid (0.1%) and acetonitrile (40:60% v/v). The instrument parameters called for a flow rate of 1 ml/min and a detection wavelength of 265 nm using the UV detector. The chromatographic method was expedited using the impurity-spiked solution. The proposed method's validity was examined in accordance with the international conference on harmonization (ICH) guidelines. The plotted calibration charts had linear regression coefficients of 0.999, indicating that their linearity was within acceptable bounds. The suggested approach is quick, easy, practical, and reasonably priced. It can be used for routine manufacturing sample analysis during stability tests and to confirm the caliber of medication samples during stability studies.

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“…This delivery system is of prime attention because of increased bioavailability, penetration, ease of self-administration i.e noninvasive delivery of therapeutic agent, no hepatic rst-pass metabolism and better patient compliance [2]. Various transdermal delivery systems have been investigated for improving drug penetration through the skin including nano carrier loaded creams, transdermal patches and micro needle patches [3]. Among these micro needles are of prime importance because of their succesfull and pain free delivery of therapeutic agent in blood stream and nally the target site [4].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

SUPRIYA,

KAMERE,

VIJAYKUMAR

2024

Preprint

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Micro needle patches are the novel dosage form in transdermal drug delivery systems with improved penetration to skin. In this study we fabricated micro needle patches containing Raloxifene an immunosuppressant drug by using polymer thiolated chitosan that in turn was developed by adding thiol group to chitosan. These micro needle patches were further evaluated for their mechanical, physical and chemical parameters. The optimized micro needle patch having 225 needles with 665 µm length, 90 µm width showed good penetration i.e 84% and better percent elongation. In-vitro and ex-vivo penetration studies on rat skin using Franz diffusion cell showed sustained release of (85%) Raloxifene in its comparative study with Raloxifene ointment. HPLC analysis also showed 91.7% release of drug from optimized formulation of micro needle patch. Finally the recent progress proved that micro needle patches of thiolated chitosan loaded with Raloxifene for transdermal drug delivery have the potential to show therapeutic outcomes with improved bioavailability and sustained release of drug over a longer period.

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Formulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P

Cited by 9 publications

References 4 publications

Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents

Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents

Analytical Method Development and Validation of Propranolol and Hydrochlorothiazide

Formulation and Evaluation of Microneedle Patch Raloxifene for Transdermal Drug Delivery

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