Formulation, Optimization, and Evaluation of Ultradeformable Nanovesicles for Effective Topical Delivery of Hydroquinone

Jamadar, Arzoo Toyeba; Peram, Malleswara Rao; Chandrasekhar, Nagesh; Kanshide, Ankita; Kumbar, Vijay; Diwan, Prakash V.

doi:10.1007/s12247-022-09657-7

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…Other similar works involving different classes of vesicular nanosystems were also found in the literature for the encapsulation of depigmenting actives, in which the following actives were addressed: N-acetyl glucosamine [69], ellagic acid [70], phenylethyl resorcinol [52], quercetin [55], kojic acid derivative [71], hydroquinone [72], tranexamic acid [73] and curcumin [74]. Table 2 presents the main studies of recent years involving vesicular nanosystems for the delivery of depigmenting actives.…”

Section: Hybrid Vesicular Nanosystemsmentioning

confidence: 95%

Nanosystems with potential application as carriers for skin depigmenting actives

Castro,

Pinto,

Dos Santos

et al. 2024

Nanotechnology

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Hyperpigmentation is a skin disorder characterized by excessive production of melanin in the skin and includes dyschromias such as post-inflammatory hyperchromias, lentigens, melasma and chloasma. Topical products containing depigmenting agents offer a less aggressive treatment option for hyperpigmentation compared to methods like chemical peels and laser sessions. However, some of these agents can cause side effects such as redness and skin irritation. Encapsulating these actives in nanosystems shows promise in mitigating these effects and improving product safety and efficacy. In addition, nanocarriers have the ability to penetrate the skin, potentially allowing for targeted delivery of actives to the affected areas. The most commonly investigated nanosystems are nanoemulsions, vesicular nanosystems and nanoparticles, in which different materials can be used to generate different compositions in order to improve the properties of these nanocarriers. Nanocarriers have already been widely explored, but it is necessary to understand the evolution of these technologies when applied to the treatment of skin hyperchromias. Therefore, this literature review aims to present the state of the art over the last 15 years on the use of nanosystems as a potential strategy for encapsulating depigmenting actives for potential application in cosmetic products for skin hyperchromia. By providing a comprehensive overview of the latest research findings and technological advances, this article can contribute to improving the care and quality of life of people affected by this skin condition.

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Section: Hybrid Vesicular Nanosystemsmentioning

confidence: 95%

Nanosystems with potential application as carriers for skin depigmenting actives

Castro,

Pinto,

Dos Santos

et al. 2024

Nanotechnology

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“…[12]The transdermal delivery system is particularly interested in liposomes and similar formulations because they can deliver both hydrophilic and lipophilic drugs. [13]However conventional liposome penetration is confined to the higher skin layers i.e., Stratum corneum, therefore they produce an effect on the upper layers and are not a viable option for the transdermal administration of drugs. [14]Enhanced drug permeation and superior contact on the surface of the skin were observed as compared to traditional liposomes, as these elastic vesicles contain penetration enhancers.…”

Section: Introductionmentioning

confidence: 99%

Transfersomes as a Surfactant-based Ultradeformable Liposome

Sharma,

Yadav,

Tickoo

et al. 2024

BIO Web Conf.

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In the modern era, there are numerous ways for drug delivery. The change in time has led to the progress of drug delivery systems gaining significant development. Even though most of the drugs are administered orally i.e., in conventional dosage form it has its limitations too like poor patient compliance, metabolism in the liver's first passage, poor absorption, and fluctuations in plasma level.Because our skin is indeed the largest organ, transdermal medication administration has received increased attention in recent years. Many lipids nanovesicles like Liposomes, Niosome, Ethosome, and Transfersomes have been developed as a carrier for transdermal drug delivery. But out of them, Transfersomes are the ones which are of great interest as they show better permeation among all as most of the other carriers cannot pass through the stratum corneum. The method of transdermal medication administration has been used to provide controlled and targeted action and can act as topical and dermal preparation. This review provides basic information about Transfersomes, their mechanism of action, applications, and comparison with other lipid nanocarriers.

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“…Hydroquinone (HQ) is a commonly used antioxidant in the field of cosmetics. 23 It is also a gold-standard therapeutic drug for melasma, postinflammatory hyperpigmentation, and other hyperpigmentation disorders. At first, hydroquinone was chosen in a previous study as a cocrystal coformer due to its antioxidant property.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Hydroquinone (HQ) is a commonly used antioxidant in the field of cosmetics . It is also a gold-standard therapeutic drug for melasma, postinflammatory hyperpigmentation, and other hyperpigmentation disorders.…”

Section: Introductionmentioning

confidence: 99%

Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point

Yao,

Jin,

Hong

et al. 2023

Crystal Growth & Design

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Levamisole hydrochloride cocrystallizes with hydroquinone in different solvates (methanol, ethanol, water, acetonitrile, and n-propanol), forming the changing Z″ cocrystal solvates from 23 to 3.33. These cocrystals were characterized by using single-crystal and powder X-ray diffraction and thermal analysis. All cocrystal solvates consist of different 2D planar sheets, which influence the Z″ value and melting point. The findings suggest a method for obtaining high Z crystals through suitable solvents. Topology analysis and Hirshfeld surface analysis were conducted to understand the Z″ transformation. Further, quantum chemistry was demonstrated as a significant tool to explain the extremely low melting point and the change of the melting point in different solid forms.

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Formulation, Optimization, and Evaluation of Ultradeformable Nanovesicles for Effective Topical Delivery of Hydroquinone

Cited by 7 publications

References 43 publications

Nanosystems with potential application as carriers for skin depigmenting actives

Nanosystems with potential application as carriers for skin depigmenting actives

Transfersomes as a Surfactant-based Ultradeformable Liposome

Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point

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