Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Obluchinskaya, E. D.; Pozharitskaya, Olga N.; Flisyuk, E. V.; Shikov, Alexander N.

doi:10.3390/md19110643

Cited by 33 publications

(25 citation statements)

References 61 publications

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“…Fucus species are consumed by populations of the coastal countries of Western Europe and Alaska [ 5 ]. Besides being utilized in food ingredients, F. vesiculosus is used in cosmetics, biofertilizers, animal feed, and in the pharmaceutical industry [ 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region

et al. 2022

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Fucus vesiculosus is one of the most prominent brown algae in the shallow waters of the seas of the Arctic region (Barents (BS), White (WS), Norwegian (NS), and Irminger (IS)). The aim of this study was to determine the biochemical composition of F. vesiculosus from the Arctic at different reproductive phases, and to evaluate the antioxidant properties of F. vesiculosus extracts. The amounts of monosaccharides, phlorotannins, flavonoids, and ash and the mineral composition significantly varied in the algae. A strong correlation was established between monosaccharide, phlorotannin, and flavonoid accumulation and water salinity (Pearson’s correlation coefficients r = −0.58, 0.83, and 0.44, respectively; p < 0.05). We noted a negative correlation between the antioxidant activity and the amount of the structural monosaccharides of fucoidan (r = −0.64). A positive correlation of phlorotannins and flavonoids with antioxidant power was confirmed for all samples. The ash accumulation was relatively lower in the sterile phase for the algae from the BS and WS. The correlation between the Metal Pollution Index (MPI) and the reproductive phases was medium with high fluctuation. Meanwhile, the MPI strongly correlated with the salinity and sampling site. The gradient of the MPI values across the sea was in the following ranking order: BS < WS < NS < IS. Taken together, and based on our data on the elemental contents of F. vesiculosus, we believe that this alga does not accumulate toxic doses of elements. Therefore, the Arctic F. vesiculosus could be safely used in food and drug development as a source of active biochemical compounds and as a source of dietary elements to cover the daily nutritional requirements of humans.

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Section: Introductionmentioning

confidence: 99%

The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region

et al. 2022

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“…Single doses (50-150 mg/kg) and multiple doses (100 mg/kg over five days) of topical application caused no signs of dryness, erythema, hemorrhage, edema or erosion/excoriation in skin rats. The kinetics of topical application of fucoidan have been also investigated by Obluchinskaya et al [139] to evaluate the anti-inflammatory activity of fucoidan extracted from Fucus vesiculosus in carrageenan-induced rat paw edema. The fucoidan-based cream dose-dependently inhibited paw edema after topical application, with an efficacy at higher doses equal to diclofenac gel, a synthetic anti-inflammatory drug used to treat pain and inflammatory diseases.…”

Section: Seaweeds In Pharmaceutical Studies and Applicationsmentioning

confidence: 99%

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

2022

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Nowadays, seaweeds are widely involved in biotechnological applications. Due to the variety of bioactive compounds in their composition, species of phylum Ochrophyta, class Phaeophyceae, phylum Rhodophyta and Chlorophyta are valuable for the food, cosmetic, pharmaceutical and nutraceutical industries. Seaweeds have been consumed as whole food since ancient times and used to treat several diseases, even though the mechanisms of action were unknown. During the last decades, research has demonstrated that those unique compounds express beneficial properties for human health. Each compound has peculiar properties (e.g., antioxidant, antimicrobial, antiviral activities, etc.) that can be exploited to enhance human health. Seaweed’s extracted polysaccharides are already involved in the pharmaceutical industry, with the aim of replacing synthetic compounds with components of natural origin. This review aims at a better understanding of the recent uses of algae in drug development, with the scope of replacing synthetic compounds and the multiple biotechnological applications that make up seaweed’s potential in industrial companies. Further research is needed to better understand the mechanisms of action of seaweed’s compounds and to embrace the use of seaweeds in pharmaceutical companies and other applications, with the final scope being to produce sustainable and healthier products.

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“…A carrageenan-induced edema model in rats was employed, and the results showed 51–58% inhibition at 50 mg/kg fucoidan, which was comparable to the diclofenac effect. Such an effect was supposed to be linked with inhibition of IL-1 β -induced COX-2 expression [ 133 ].…”

Section: Potential Pharmacological Activitiesmentioning

confidence: 99%

Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities

et al. 2022

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Fucoidans encompass versatile and heterogeneous sulfated biopolysaccharides of marine origin, specifically brown algae and marine invertebrates. Their chemistry and bioactivities have been extensively investigated in the last few decades. The reported studies revealed diverse chemical skeletons in which l-fucose is the main sugar monomer. However, other sugars, i.e., galactose, mannose, etc., have been identified to be interspersed, forming several heteropolymers, including galactofucans/fucogalactans (G-fucoidans). Particularly, sulfated galactofucans are associated with rich chemistry contributing to more promising bioactivities than fucans and other marine polysaccharides. The previous reports in the last 20 years showed that G-fucoidans derived from Undaria pinnatifida were the most studied; 21 bioactivities were investigated, especially antitumor and antiviral activities, and seven unique biomedical applications compared to other marine polysaccharides were demonstrated. Hence, the current article specifically reviews the biogenic sources, chemistry, and outstanding bioactivities of G-fucoidans providing the opportunity to discover novel drug candidates.

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Formulation, Optimization and In Vivo Evaluation of Fucoidan-Based Cream with Anti-Inflammatory Properties

Cited by 33 publications

References 61 publications

The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region

The Biochemical Composition and Antioxidant Properties of Fucus vesiculosus from the Arctic Region

An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications

Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities

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