Formulation Optimization of Gentamicin Loaded Eudragit RS100 Microspheres Using Factorial Design Study

Singh, Deependra; Saraf, Swarnlata; Dixit, Vinod Kumar; Saraf, Shailendra

doi:10.1248/bpb.31.662

Cited by 12 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The addition of antibacterial agents into electrospun fibers has been a thrust area of research for clinicians especially as antibiotic-resistant bacteria strains increasingly emerge [31]. Gentamicin sulfate is a bactericidal aminoglycoside antibiotic that is widely used for the treatment of bacterial infections [32]. Electrospun nanofibers could increase the drug efficiency and drug solubility in aqueous solution due to their high surface-to-volume ratio.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Dwivedi

Pandey

et al. 2019

Pharmaceutics

View full text Add to dashboard Cite

Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of recombinant human epidermal growth factor (rhEGF) and gentamicin sulfate at the wound site to hasten the process of diabetic wound healing and inactivation of bacterial growth. The physicochemical characterization of the fabricated scaffolds was carried out using scanning electron microscopy (SEM) and X-ay diffraction (XRD). The scaffolds were analyzed for thermal stability using thermogravimetric analysis and differential scanning calorimetry. The porosity, biodegradability, and swelling behavior of the scaffolds was also evaluated. Encapsulation efficiency, drug loading capacity, and in vitro drug release were also investigated. Further, the bacterial inhibition percentage and detailed in vivo biocompatibility for wound healing efficiency was performed on diabetic C57BL6 mice with dorsal wounds. The scaffolds exhibited excellent wound healing and continuous proliferation of cells for 12 days. These results support the applicability of such systems in rapid healing of diabetic wounds and ulcers.

show abstract

Section: Introductionmentioning

confidence: 99%

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Dwivedi

Pandey

et al. 2019

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Propranolol is 8-10 times less powerful than it. It requires frequent administration of doses to maintain therapeutic drug levels since it rapidly absorbs from the gastrointestinal tract with a peak plasma concentration of 5-10 ng/mL after 1 h and is metabolised up to 80% in the liver with a mean half-life of 2.0-2.5 h [4] Swarnlata et al [22] two different kinds of polymer patches were created: one using polyvinyl alcohol (PVA) alone and the other combining hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC). HPMC 10% and EC 10% polymer solutions were made using a 1:1 combination of methanol and chloroform.…”

Section: Antihypertensive Drugs Timolol Maleatementioning

confidence: 99%

Pharmacological activities of anti-hypertensive drug delivery through a transdermal patch – a brief review

Mahammad,

Sinha Mahapatra,

Das

et al. 2022

UJPSR

View full text Add to dashboard Cite

One of the methods falling under the category of controlled drug delivery is the transdermal drug delivery system (TDDS), which is designed to distribute the medicine via the skin at a predefined and regulated pace. Hypertension is one of the largest death-causing diseases in mankind. Since it is a chronic disease, it required continuous treatment. The disadvantages of antihypertensive drugs such as more frequent administration, extensive first-pass metabolism and variable bioavailability, making them an ideal candidate for transdermal drug delivery systems. This article is dedicated to reviewing antihypertensive transdermal patches from the perspective of enhancing bioavailability and improving patient compliance. The various antihypertensive drugs considered in the review include timolol maleate, nicardipine hydrochloride, captopril, verapamil hydrochloride, nifedipine, propranolol hydrochloride, diltiazem hydrochloride, amlodipine besilate and carvedilol. Clonidine was the first antihypertensive drug developed in the transdermal form. Recently, various antihypertensive transdermal patches are available in the pharmaceutical market. Most of the reported methods in the literature employed the solvent evaporation method or solvent casting method for the preparation of transdermal patches. Depending on the release required over some time, the concentrations of polymer, plasticizer and penetrant were varied.

show abstract

“…The wound should be free from infection and all factors inhibiting natural healing process should be absent. The treatment becomes difficult as the bacterium is localized intracellularly since all the antibiotics are effective against the microbes in vitro 5 .…”

Section: Quick Response Codementioning

confidence: 99%

Untitled

2013

IJPSR

View full text Add to dashboard Cite

The extracellular matrix (ECM) is the backbone in controlling cell behavior in the living organisms during the process of wound healing. The design of a suitable biomimetic nanofibrous scaffold which mimics the properties of natural ECM is a need of present time. In order to create a novel and unique wound dressing material, composite nanoscaled eudragit scaffolds loaded with gentamicin were prepared using the process of electrospinning. The nanofibers were characterized for size, size distribution, surface morphology and surface chemical structures using the Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). In-vitro release of gentamicin was also investigated. In vitro drug release tests confirmed that the nanofibers had pH-dependent drug release profiles. These properties indicate that the drug loaded eudragit nanofibrous scaffold has the potential to be used as a candidate in wound healing treatments.

show abstract

Formulation Optimization of Gentamicin Loaded Eudragit RS100 Microspheres Using Factorial Design Study

Cited by 12 publications

References 25 publications

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing

Pharmacological activities of anti-hypertensive drug delivery through a transdermal patch – a brief review

Untitled

Contact Info

Product

Resources

About