Formulation Test of Preparations Face Mist Combination of Pomegranate Peel Extract and Mangosteen Peel as an Antioxidants

Abstract

Face mist is one of the cosmetics in the form of a spray, which functions as a refresher and moisturizer with the use of being directly sprayed onto the facial skin. Combining two antioxidants that work to increase the activity of preventing the effects of radiation and free radicals. Face mist is made from a combination of pomegranate peel extract (Punica granatum L.) and mangosteen peel (Garcinia mangostana L.).To obtain a formulation and evaluate the physical stability of apreparation with a face mist combination of pomegranate peel extract (Punica granatum L.) and mangosteen peel (Garcinia mangostana L.) as an antioxidant.Experimental research with One-Shoot Case Study design. Made three combination formulations of pomegranate peel and mangosteen peel extract. Then the formulation was seen from the results of the evaluation of its physical stability including organoleptic tests, homogeneity, pH, viscosity, facial moisture, spraying patterns, dry time, and antioxidant tests using the DPPH method. Analysis data One Way Anova showed that there was no significant difference in the pH, viscosity and skin moisture test. Evaluation and physical stability 21 days organoleptic test, homogeneity obtained all formulas meet the standards, pH test and dry time formula II most meet the standards, viscosity test formula III most meet the standards, formula I meets the standards for spraying pattern test, skin moisture and % inhibition highest in the antioxidant test. The preparation face mist most optimalis formula I with a ratio of pomegranate peel extract and mangosteen peel (10:15).

Study of the Impact of Side Effects of Using Off-Label Drugs in Patients with Systemic Lupus Erythematosus on Health Costs

“…This study is a retrospective study that tracks lupus patients and uses a tool such as the Naranjo algorithm to determine the side effects associated with off-label drugs for lupus disease [7]. This study also used a cost analysis of drug use due to off-label adverse drug events [8]. This analysis can be used to estimate the additional cost caused by each additional unit of outcome [9].…”

Karakteristik Face Mist Dengan Perlakuan Formulasi Kombinasi Ekstrak Kulit Nanas (Ananas comosus (L.) Merr) Dan Bunga Telang (Clitoria ternatea L.)

“…Face mist adalah skincare berbentuk spray yang mudah diaplikasikan dan memiliki banyak manfaat seperti melembabkan, menyegarkan, serta menghidrasi lapisan kulit wajah (Apriliani, 2016;Apristasari et al, 2018;Widyasanti & Fauziyah, 2022). Menurut Lisyanti et al (2022), antioksidan merupakan salah satu bahan penyusun dalam pembuatan face mist. Antioksidan juga banyak digunakan dalam berbagai produk perawatan kulit dan kosmetik (Haerani et al, 2018).…”

“…Antioksidan juga banyak digunakan dalam berbagai produk perawatan kulit dan kosmetik (Haerani et al, 2018). Lebih lanjut dijelaskan bahwa antioksidan memiliki manfaat sebagai berikut: mengatasi kulit kering (melembabkan), mencegah terjadinya penuaan dini, menangkal radikal bebas, serta melindungi kulit dari berbagai kerusakan sel akibat radiasi UV dan ROS (reactive oxygen species) (Haerani et al, 2018;Lisyanti et al, 2022). Terdapat dua jenis antioksidan yaitu antioksidan sintetis dan alami.…”

“…Perlakuan terbaik ditentukan sesuai dengan kriteria face mist. Face mist yang dihasilkan harus memenuhi kriteria uji yang sudah ditetapkan meliputi pH pada range 4,5 -6,5, sesuai viskositas larutan, organoleptik yang disukai panelis, dan semua face mist homogen (Lisyanti et al, 2022). Daya sebar semprotan yang baik untuk face mist pada range 5 -7 cm dan memiliki waktu kering kurang dari 5 menit (Sakka & Hasma, 2023).…”

“…Tabel 2 menunjukkan bahwa pH face mist berkisar antara 3,8±0,06 sampai 7,5±0,00. Menurut Lisyanti et al (2022), face mist yang baik memiliki kriteria pH pada interval 4,5-6,5. Berdasarkan Tabel 2 face mist dengan perlakuan ekstrak kulit nanas : ekstrak bunga telang (1,75:5,25) dan ekstrak kulit nanas : ekstrak bunga telang (3,5:3,5) termasuk dalam kriteria pH face mist yang baik.…”