Formylpeptide Receptor Single Nucleotide Polymorphism 348T&gt;C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Maney, Pooja; Walters, John D.

doi:10.1902/jop.2009.090103

Cited by 23 publications

(16 citation statements)

References 33 publications

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“… 35 Second, the Fpr1 −/− mice model had accelerated mortality and increased bacterial burden in the liver and spleen early after infection, 36 showing a role of Fpr1 in the host defense. Moreover, rs5030879 (c.348C>T, I116I) in FPR1 is associated with aggressive periodontitis, 37 which is an infectious–inflammatory disease. In addition, c.329T>C (F110S), c.378C>G (C126W), and rs5030878 (c.32C>T, I11T) of FPR1 are significantly correlated with defective polymorphonuclear neutrophil (PMN) function and C-reactive protein.…”

Section: Discussionmentioning

confidence: 99%

FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy

Liang

Chen

et al. 2014

Eye

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PurposeTo determine the genetic association of an inflammation-related gene, formyl peptide receptor 1 (FPR1), in exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV).MethodsThe coding region of FPR1 gene was sequenced in 554 unrelated Chinese individuals: 155 exudative AMD patients, 179 PCV patients, and 220 controls. Interactions and combined effects of FPR1 with complement factor H (CFH), high temperature requirement factor A1 (HTRA1), and smoking were also investigated.ResultsA total of 28 polymorphisms in FPR1 were identified. Single nucleotide polymorphisms (SNP) rs78488639 increased the risk to exudative AMD (P=0.043) and PCV (P=0.016), whereas SNP rs867229 decreased the risk to exudative AMD (P=0.0026), but not PCV. Homozygous G allele of rs1042229 was associated with exudative AMD (P=0.0394, odds ratio (OR)=2.27, 95% confident interval: 1.08–4.74), but not with PCV. Exudative AMD, but not PCV, was associated with the heterozygous genotypes of rs2070746 (P=0.019, OR=0.57) and rs867229 (P=0.0082, OR=0.54). Significantly, interactions were identified among FPR1 rs78488639, CFH rs800292, and HTRA1 rs11200638 in both exudative AMD and PCV. Combined heterozygous risk alleles of CFH rs800292 GA and FPR1 rs78488639 CA were posed to PCV (P=2.22 × 10−4, OR=10.47), but not exudative AMD. Furthermore, FPR1 rs78488639 CA combining with HTRA1 rs11200638 and smoking was also predisposed risks to exudative AMD and PCV.ConclusionFPR1 is associated with exudative AMD and PCV in a Hong Kong Chinese cohort. FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.

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Section: Discussionmentioning

confidence: 99%

FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy

Liang

Chen

et al. 2014

Eye

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“…Furthermore, a T348T/T mutation, although not altering FPR1 receptor number, was associated with impaired fMLF-induced neutrophil chemotaxis and aggressive periodontitis in an African-American population. 26 Meanwhile, the association of the C32T SNP with the development of hypertension in younger adults, as well as the D192K polymorphism with the onset of gastric carcinoma in an elderly Japanese population, have also been described, although their mechanistic and functional relevance is yet to be determined. 27,28 In contrast, the V101L SNP is associated with increased binding affinity for the FPR1 antagonist cyclosporin H. 29 With increasing application of genome-wide association studies, it remains to be seen whether other SNPs are associated with altered susceptibility to inflammatory diseases or infection.…”

Section: Polymorphisms Within Fpr1mentioning

confidence: 99%

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

Dorward

Lucas

Chapman

et al. 2015

The American Journal of Pathology

210

200

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Neutrophil migration to sites of inflammation and the subsequent execution of multiple functions are designed to contain and kill invading pathogens. These highly regulated and orchestrated processes are controlled by interactions between numerous receptors and their cognate ligands. Unraveling and identifying those that are central to inflammatory processes may represent novel therapeutic targets for the treatment of neutrophil-dominant inflammatory disorders in which dysregulated neutrophil recruitment, function, and elimination serve to potentiate rather than resolve an initial inflammatory insult. The first G protein-coupled receptor to be described on human neutrophils, formyl peptide receptor 1 (FPR1), is one such receptor that plays a significant role in the execution of these functions through multiple intracellular signaling pathways. Recent work has highlighted important observations with regard to both receptor function and the importance and functional relevance of FPR1 in the pathogenesis of a range of both sterile and infective inflammatory conditions. In this review, we explore the multiple components of neutrophil migration and function in both health and disease, with a focus on the role of FPR1 in these processes. The current understanding of FPR1 structure, function, and signaling is examined, alongside discussion of the potential importance of FPR1 in inflammatory diseases suggesting that FPR1 is a key regulator of the inflammatory environment.

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“…A few additional SNPs were tested for the haplotype effect but the P value failed to change, suggesting that the rs5030879 SNP was contributing the most effect. This group's other publication reported analysis of the same 6 SNPs as Zhang et al's group, in another set of 30 AgP and 33 healthy African‐Americans as well as a set of Turkish subjects . The T allele of rs5030879, and the TT genotype, were associated in African‐Americans ( P = .021), as well as some 2‐point haplotypes involving that SNP.…”

Section: Candidate Gene Studies In Aggressive Periodontitismentioning

confidence: 99%

Genetic polymorphisms and periodontal disease in populations of African descent: A review

Gonçalves

Harris

Elmariah

et al. 2017

J of Periodontal Research

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Aggressive periodontitis is a rare but rapidly progressing form of periodontal disease that usually affects otherwise systemically healthy individuals, at a young age. It usually affects first molars and incisors, which are usually lost if treatment is not properly and early rendered. Although of low prevalence, it affects individuals of African descent at a higher prevalence, and usually multiple members within the same family. Several studies have been performed in the attempt to evaluate specific single nucleotide polymorphisms (SNPs) that could be associated with this disease. To the best of our knowledge, the present article provides the first review of the literature focusing on studies that evaluated SNPs in patients of African descent with aggressive periodontitis. Several SNPs have been evaluated in different genes according to their role in the pathogenesis of the disease, with positive and negative associations (such as IL1, FCGR3B, FPR1, LTF, CYBA, GLT6D1, TLR4) with both the localized and generalized forms of aggressive periodontitis. Given the complexity of periodontitis, the difficulty in gathering large cohorts diagnosed with this rare form of disease, and the fact that candidate gene studies may only determine part of the genetic risk of a disease, the search for specific SNPs associated with aggressive periodontitis seems to be a long one, most likely to result in the combination of multiple SNPs, in multiple genes.

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Formylpeptide Receptor Single Nucleotide Polymorphism 348T>C and Its Relationship to Polymorphonuclear Leukocyte Chemotaxis in Aggressive Periodontitis

Cited by 23 publications

References 33 publications

FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy

FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

Genetic polymorphisms and periodontal disease in populations of African descent: A review

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