Fosfomycin for antibiotic prophylaxis in men undergoing a transrectal prostate biopsy: A systematic review and meta-analysis

Gu, Hui Mo; Gu, J.S.; Lim, D.G.; Ryu, J.W.; Yu, S.H.; Chung, H.S.; Oh, K.J.; Kim, S.O.; Kang, T.W.; Jung, S.I.; Kwon, D.D.; Park, K.S.; Jung, J.H.; Hwang, E.C.; Dahm, P.

doi:10.1016/s0302-2838(23)00775-3

Cited by 2 publications

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“…62 Whereas FQs are considered the prophylactic gold standard in the case of prostate biopsy, a recent South Korean study showed that fosfomycin has a similar impact on preventing an infectious onset. 63 EAU guidelines recommend the use of target prophylaxis based on rectal swabs or stool culture for transrectal biopsy. An alternative is augmented prophylaxis (two or more different classes of antibiotics) without FQs or alternative antibiotics (e.g.…”

Section: Prostate Biopsymentioning

confidence: 99%

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Antibiotic prophylaxis in urologic interventions: Who, when, where?

Marino,

Rossi,

Murri

et al. 2024

Urologia

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Background: Periprocedural prophylaxis in medicine encompasses the set of measures (physical, chemical, and pharmacological) used to reduce the risk of infection. Antibiotic prophylaxis (AP) refers to the administration of a short-term regimen of antibiotics shortly before a medical procedure to reduce the risk of infectious complications that can result from diagnostic and therapeutic interventions. The outspreading growth of multidrug-resistant bacterial species and changes in the bacterial local ecosystem have impeded the development of a unique scheme of AP in urology. Objectives: To review the literature and current guidelines regarding AP for urological diagnostic and therapeutic procedures, and to define agents, timing, and occasions when administering pharmacological prophylaxis. Secondly, according to current literature, to open new scenarios where AP can be useful or useless. Results: Major gaps in evidence still exist in this field. AP appears useful in many invasive procedures and some sub-populations at risk of infectious complications. AP is not routinely recommended for urodynamic exams, diagnostic cystoscopy, and extracorporeal shock-wave lithotripsy. The available data regarding the use of AP during the transperineal prostate biopsy are still unclear; conversely, in the case of the transrectal approach AP is mandatory. AP is still considered the gold standard for the prevention of postoperative infective complications in the case of ureteroscopy, percutaneous nephrolithotomy, endoscopic resection of bladder tumor, endoscopic resection of the prostate, and prosthetic or major surgery. Conclusion: The review highlights the complexity of determining the appropriate candidates for AP, emphasizing the importance of considering patient-specific factors such as comorbidities, immunocompetence, and the nature of the urologic intervention. The evidence suggests that a one-size-fits-all approach may not be suitable, and a tailored strategy based on the specific procedure and patient characteristics is essential.

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Section: Prostate Biopsymentioning

confidence: 99%

Section: Diagnostic Proceduresmentioning

confidence: 99%

Antibiotic prophylaxis in urologic interventions: Who, when, where?

Marino,

Rossi,

Murri

et al. 2024

Urologia

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“…Крім того, існує достатня експериментально-клінічна база достовірно більш високої ефективності однократного вживання фосфоміцину порівняно з фторхінолонами, цефалоспоринами та триметоприм-сульфаметоксазолу для периоперативної антибіотикопрофілактики інфекційно-септичних ускладнень при трансректальній біопсії передміхурової залози [50,52,67].…”

Section: ефективність фосфоміцину при інфекціях сечових шляхівunclassified

New Horizons for the Role of Fosfomycin in the Era of Multi-drug Resistant Urinary Tract Infections

Shostak,

Kostyev,

Krasylyuk

et al. 2023

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The genital-urinary system is a complex of organs which are anatomically and physiologically interconnected. Therefore, infectious diseases of the urinary tract can affect the urethra, bladder and urethra, kidneys and prostate gland. Urinary tract infections (UTIs) are characterized by the presence of bacteria, viruses, fungi or parasites in the urinary tract, which cause inflammation and form the clinical picture of the disease. Despite the fact that fosfomycin is an antibiotic with a long history, it has unique properties that make it an effective antibiotic therapy for UTIs with consistently low resistance patterns of uropathogens. It is an antibacterial drug with a chemical structure that is not similar to other known antibiotics and is considered a strong alternative in the treatment of infections caused by multi-resistant pathogens, has a wide spectrum of action against gram-positive and gram-negative microorganisms, including many antibiotic-resistant microorganisms. Current data indicate the ability to penetrate biofilms of uropathogens, synergistically enhance the transport of other antibiotics inside bacterial cells, as well as a significant reduction in the virulence of pathogens when fosfomycin resistance is acquired. Fosfomycin has such advantages as a high concentration in the urinary tract, a minimal effect on the gastrointestinal flora and a practical lack of tendency to form resistance. Today, the safety and effectiveness of the drug has been proven as a means of antibiotic prophylaxis after operations on the lower urinary tract, transrectal biopsy of the prostate gland and frequently recurrent UTIs, in the treatment of asymptomatic bacteriuria and UTIs during pregnancy, in the treatment of chronic bacterial prostatitis, as well as a part of antimicrobial measures in multiresistant bacterial strains.

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Fosfomycin for antibiotic prophylaxis in men undergoing a transrectal prostate biopsy: A systematic review and meta-analysis

Cited by 2 publications

References 0 publications

Antibiotic prophylaxis in urologic interventions: Who, when, where?

Antibiotic prophylaxis in urologic interventions: Who, when, where?

New Horizons for the Role of Fosfomycin in the Era of Multi-drug Resistant Urinary Tract Infections

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