FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug resistance
Shuping Wang,
Xiaolong Liu,
Xueyan Zhang
et al.
Abstract:Background
Targeted therapy is a key strategy for the treatment of advanced and metastatic pancreatic cancer, one of the leading causes for cancer-related death worldwide. To address the limitations of existing targeted drugs, there is an urgently need to find novel targets and therapeutic strategies. Transcription factor FOSL1 is a potential therapeutic target for challenging pancreatic cancer, which contributes to the malignant progression and poor gnosis of pancreatic cancer.
Methods
Human FOSL1 complete … Show more
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