Foundational model of structural connectivity in the nervous system with a schema for wiring diagrams, connectome, and basic plan architecture

Swanson, Larry W.; Bota, Mihail

doi:10.1073/pnas.1015128107

Cited by 82 publications

(92 citation statements)

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“…All relevant data in the primary literature were interpreted in the only available standard, hierarchically organized, annotated nomenclature for the rat brain (Dataset S1), using descriptive nomenclature defined in the foundational model of connectivity (11,12). Association and commissural connection reports were assigned ranked qualitative connection weights based on pathway tracing methodology, injection site location and extent, and anatomical density.…”

Section: Methodsmentioning

confidence: 99%

“…The analysis is based on a directed, weighted macroconnectome of association connections (between ipsilateral parts) and commissural connections (between parts on one side and those on the other side), using the same basic strategy and methodology applied to the rat cerebral cortical association macroconnectome (10) but with additional analytical approaches and curation tools. In this approach a macroconnection is defined as a monosynaptic axonal (directed, from/to) connection between two nervous system gray matter regions or between a gray matter region and another part of the body (such as a muscle) (11,12). All 45 gray matter regions of the cerebral nuclei on each side of the brain were included in the analysis.…”

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confidence: 99%

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Network architecture of the cerebral nuclei (basal ganglia) association and commissural connectome

Swanson

Sporns

Hahn

2016

Proc. Natl. Acad. Sci. U.S.A.

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The cerebral nuclei form the ventral division of the cerebral hemisphere and are thought to play an important role in neural systems controlling somatic movement and motivation. Network analysis was used to define global architectural features of intrinsic cerebral nuclei circuitry in one hemisphere (association connections) and between hemispheres (commissural connections). The analysis was based on more than 4,000 reports of histologically defined axonal connections involving all 45 gray matter regions of the rat cerebral nuclei and revealed the existence of four asymmetrically interconnected modules. The modules form four topographically distinct longitudinal columns that only partly correspond to previous interpretations of cerebral nuclei structure-function organization. The network of connections within and between modules in one hemisphere or the other is quite dense (about 40% of all possible connections), whereas the network of connections between hemispheres is weak and sparse (only about 5% of all possible connections). Particularly highly interconnected regions (rich club and hubs within it) form a topologically continuous band extending through two of the modules. Connection path lengths among numerous pairs of regions, and among some of the network's modules, are relatively long, thus accounting for low global efficiency in network communication. These results provide a starting point for reexamining the connectional organization of the cerebral hemispheres as a whole (right and left cerebral cortex and cerebral nuclei together) and their relation to the rest of the nervous system. behavior | connectomics | mammal | neural connections | neuroinformatics T he paired adult vertebrate cerebral hemispheres are differentiations of the embryonic neural tube's endbrain (telencephalic) vesicle, which in turn forms a ventral nonlaminated part, the cerebral nuclei, and then a dorsal laminated part, the cerebral cortex (1-3). In mammals the largest parts of the cerebral nuclei by volume are the caudoputamen (striatal) and globus pallidus (pallidal). Together, they are commonly regarded as the endbrain parts of the basal ganglia (3), which play an important role in controlling skeletomuscular (somatic) movements and in the etiology of movement disorders (4).A major shift in thinking about the basal ganglia occurred with the recognition that certain ventral parts of the cerebral nuclei display the same basic circuit organization, but involve different parts of a cerebral cortex to cerebral nuclei to thalamus to cerebral cortex loop (5). This finding led to an expanded view of the basal ganglia, with dorsal and ventral striatopallidal subsystems involved primarily in movement (dorsal) and motivational functionality (ventral) (6). Complete expansion of the view was then proposed on the basis of connectional, gene expression, embryological, and functional evidence (7). It was hypothesized that the entire cerebral cortex, cerebral nuclei, and thalamus can be divided into four basic subsystems involving dorsal, vent...

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

Network architecture of the cerebral nuclei (basal ganglia) association and commissural connectome

Swanson

Sporns

Hahn

2016

Proc. Natl. Acad. Sci. U.S.A.

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“…Parceling of the rat brain, terminology for describing morphological features of tracerlabeled axons and cell bodies, and mapping strategies and procedures follow Swanson (2004) and Swanson and Bota (2010).…”

Section: Antibody Specificitymentioning

confidence: 99%

“…As was done for mapping the sites of the tracer deposits, an adjacent series of thionin-stained tissue sections was used as an aid in determining cytoarchitectural boundaries for brain regions. Parceling of the rat brain, terminology for describing morphological features of tracerlabeled axons and cell bodies, and mapping strategies and procedures follow Swanson (2004) and Swanson and Bota (2010).…”

Section: Antibody Specificitymentioning

confidence: 99%

“…PHA-L-labeled axons and CTB-labeled neurons were plotted similarly, either with the camera lucida method and then transposed (as described), or directly onto the digitized atlas maps. As was done for mapping the sites of the tracer deposits, an adjacent series of thionin-stained tissue sections was used as an aid in determining cytoarchitectural boundaries for brain regions.Parceling of the rat brain, terminology for describing morphological features of tracerlabeled axons and cell bodies, and mapping strategies and procedures follow Swanson (2004) and Swanson and Bota (2010).Individual photomicrographs were taken with a microscope-mounted digital camera (Hamamatsu Orca ER/Zeiss Axio Imager.Z1) at a resolution of 1 megapixel, and stored as 8-bit TIFF files. The digital images were captured with imaging software (Zeiss AxioVision); in some instances digital montages were produced by using a software tiling feature.…”

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Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

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The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems-motor, sensory, cognitive, and behavioral state -included in a basic structure-function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire. INDEXING TERMShypothalamus; periaqueductal gray; hippocampal formation; behavior; motivation An emerging view of the lateral hypothalamic area (LHA) reveals a highly regionally differentiated neuronal architecture with correspondingly differentiated axonal connections characterized by an extensive divergent and convergent topographic organization (Swanson, 2004;Goto et al., 2005;Swanson et al., 2005;Hahn, 2010;Hahn and Swanson, 2010). Such an organization calls for an equivalently extensive comparative analysis of the underlying organization of the severally parceled LHA (16 provisional LHA regions within the hypothalamic lateral zone) (Swanson, 2004). In a previous article (Hahn and Swanson, 2010), we presented the results of a high-resolution analysis of the axonal inputs and outputs of the lateral hypothalamic area (LHA) juxtaparaventricular (LHAjp) and suprafornical (LHAs) regions-two differentiations of the hypothalamic lateral zone middle group within NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript respectively a medial (LHAjp) and perifornical (LHAs) tier of a recently revised parcellation for the LHA (Swanson, 2004;Swanson et al., 2005).The previous work showed that the LHAjp and LHAs have interregional connections with several hundred distinct gray matter regions encompassing all four subsystems (motor, sensory, cognitive, and...

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Towards a Terminologia Neuroanatomica

et al. 2016

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This article deals with a recent revision of the terminology of the Sections Central Nervous System (CNS; Systema nervosum centrale) and Peripheral Nervous System (PNS; Systema nervosum periphericum) of the Terminologia Anatomica (TA, 1998) and the Terminologia Histologica (TH, 2008). These sections were extensively updated by the Federative International Programme for Anatomical Terminology (FIPAT) Working Group Neuroanatomy of the International Federation of Associations of Anatomists (IFAA). After extensive discussions by FIPAT, and consultation with the IFAA Member Societies, these parts were merged to form a Terminologia Neuroanatomica (TNA). After validation at the IFAA Executive Meeting, September 22, 2016, the TNA has been placed on the open part of the FIPAT website (http://FIPAT.library.dal.ca) as the official FIPAT Terminology. This article outlines the major differences between the TNA and the TA. Clin. Anat. 30:145-155, 2017. © 2016 Wiley Periodicals, Inc.

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Foundational model of structural connectivity in the nervous system with a schema for wiring diagrams, connectome, and basic plan architecture

Cited by 82 publications

References 35 publications

Network architecture of the cerebral nuclei (basal ganglia) association and commissural connectome

Network architecture of the cerebral nuclei (basal ganglia) association and commissural connectome

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Towards a Terminologia Neuroanatomica

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