Four cases of soft palate squamous cell carcinoma that responded to concomitant superselective chemoradiotherapy

Abstract

We describe our experience with 4 patients who had squamous cell carcinoma of the soft palate treated by superselective intra-arterial chemoradiotherapy. Two patients had stage Ⅱ disease, and 2 had stage Ⅳ disease. Two of them presented regional lymph node metastatsis. All patients received cisplatin alone. The mean total dose of cisplatin was 461.3mg(300-600mg). Cisplatin was injected into the facial artery or the ascending palatal artery through the superficial temporal artery, with 200 mol times of sodium thiosulfate as the cisplatin neutralizer. All patients received radiotherapy in a dose of 66 Gy and had a complete response. The primary tumor recurred in 1 patient, but was successfully resected by salvage surgery. All patients were alive at an average follow-up of 58.6 months.