Four functional magnetic resonance imaging techniques for skeletal muscle exploration, a systematic review

Caroca, Sergio; Villagran, Diego; Chabert, Stéren

doi:10.1016/j.ejrad.2021.109995

Cited by 10 publications

(5 citation statements)

References 71 publications

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“…These merits make ASL suitable not only for routine brain perfusion examination but also for perfusion studies in other body parts [ 12 , 13 , 14 , 16 , 17 , 18 , 21 , 22 , 23 , 33 ]. Although many studies have been published in the musculoskeletal field, those studies have focused mainly on exercise and peripheral arterial disease [ 26 , 34 , 35 , 36 ]. Recently, a study investigating musculoskeletal tumors found that ASL was able to diagnose malignant tumors efficiently and effectively [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

et al. 2022

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Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is used to perform perfusion imaging without administration of contrast media. However, the reliability of ASL for musculoskeletal tumors and the influence of post-labeling delay (PLD) have not been fully clarified. This study aimed to evaluate the performance of ASL with different PLDs in the imaging of musculoskeletal tumors. Forty-five patients were enrolled and were divided into a malignant group, a hypervascular benign group, a hypovascular benign group and a control group. The tissue blood flow (TBF) of the lesions and normal muscles was measured and the lesion-to-muscle TBF ratio and differences were calculated. The results showed that both the TBF of lesions and muscles increased as the PLD increased, and the TBF of muscles correlated significantly and positively with the TBF of lesions (all p < 0.05). The TBF and lesion-to-muscle TBF differences of the malignant lesions were significantly higher than those of the hypovascular benign lesions and the control group in all PLD groups (all p < 0.0125) and only those of the hypervascular benign lesions in the longest PLD (3025 ms) group (p = 0.0120, 0.0116). In conclusion, ASL detects high TBF in malignant tumors and hypervascular benign lesions, and a longer PLD is recommended for ASL to differentiate musculoskeletal tumors.

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Section: Discussionmentioning

confidence: 99%

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

et al. 2022

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“…In this section, we will provide a concise overview of the application of CT, MRI, and nuclear imaging modalities in perfusion imaging. An in-depth exploration of perfusion imaging techniques and their clinical applications can be found in other comprehensive reviews [ 18 , 125 , 126 , 127 ].…”

Section: Non-invasive Perfusion Imaging In Padmentioning

confidence: 99%

“…IVIM-MRI assesses the translational motions inside a voxel, including molecular diffusion of water and microperfusion in the capillary network, and it has been used to assess quantitative changes in lower limb muscle perfusion and evaluate foot microperfusion in PAD patients. Despite their advantages, including the ability to perform examinations without radiation and, in some cases, without contrast agents, these MRI techniques are time-consuming, require patient cooperation, and require specific equipment and specialized personnel [ 125 , 126 ].…”

Section: Non-invasive Perfusion Imaging In Padmentioning

confidence: 99%

Multi-Modality Imaging of Atheromatous Plaques in Peripheral Arterial Disease: Integrating Molecular and Imaging Markers

Wang

Nai

Gan

et al. 2023

IJMS

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Peripheral artery disease (PAD) is a common and debilitating condition characterized by the narrowing of the limb arteries, primarily due to atherosclerosis. Non-invasive multi-modality imaging approaches using computed tomography (CT), magnetic resonance imaging (MRI), and nuclear imaging have emerged as valuable tools for assessing PAD atheromatous plaques and vessel walls. This review provides an overview of these different imaging techniques, their advantages, limitations, and recent advancements. In addition, this review highlights the importance of molecular markers, including those related to inflammation, endothelial dysfunction, and oxidative stress, in PAD pathophysiology. The potential of integrating molecular and imaging markers for an improved understanding of PAD is also discussed. Despite the promise of this integrative approach, there remain several challenges, including technical limitations in imaging modalities and the need for novel molecular marker discovery and validation. Addressing these challenges and embracing future directions in the field will be essential for maximizing the potential of molecular and imaging markers for improving PAD patient outcomes.

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“…Since deoxyhemoglobin shortens T2* relaxation time, R2* (= 1/T2* relaxation time) can re ect the relative content of deoxyhemoglobin in tissue and is regarded as a quantitative parameter of signal attenuation in BOLD images. Currently, R2* value has been widely utilized in assessing cerebrovascular reactivity [10], muscle activation [11,12], renal function [13,14], blood perfusion and histopathological status of tumors [15][16][17][18]. Especially, BOLD MRI has been demonstrated to be effective in evaluating the treatment response and prognosis to chemoradiotherapy in various tumors, such as prostate [19], cervical [20,21] and breast cancer [22].…”

Section: Introductionmentioning

confidence: 99%

Value of blood oxygenation level-dependent magnetic resonance imaging in early evaluation of the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: A preliminary study

Zheng

Zhang

Zhu

et al. 2023

Preprint

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Background To establish a quantitative imaging predictor for evaluation of early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma (ESCC), using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). Methods The R2* values were obtained pre and 2–3 weeks post-dCRT in 28 patients with EC using BOLD MRI. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare the differences of R2*-related parameters between the complete response (CR) and the non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic (ROC) curve analysis. The 3-year overall survival (OS) was evaluated using Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis. Results The post-R2*, ∆R2*, and ∆%R2* in the CR group were significantly higher than those in the non-CR group (P = 0.002, 0.003, and 0.006, respectively). The R2*-related parameters showed good prediction of tumor response, with AUC ranging from 0.813 to 0.872. The 3-year OS rate in patients with ∆R2* >-7.54 s− 1 or CR were significantly longer than those with ∆R2* ≤ -7.54 s− 1 (72.37% vs. 0.00%; Hazard ratio, HR = 0.196; 95% confidence interval, 95% CI = 0.047–0.807; P = 0.024) or non-CR (76.47% vs. 29.27%; HR = 0.238, 95% CI = 0.059–0.963; P = 0.044). Conclusions The preliminary results demonstrated that the R2* value might be a useful hypoxia imaging predictor for response and prognosis of ESCC treated with dCRT. BOLD MRI may be used as a potential tool for evaluating tumor oxygenation metabolism, which is routinely applied in clinical practice and beneficial to clinical decision-making.

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Four functional magnetic resonance imaging techniques for skeletal muscle exploration, a systematic review

Cited by 10 publications

References 71 publications

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay

Multi-Modality Imaging of Atheromatous Plaques in Peripheral Arterial Disease: Integrating Molecular and Imaging Markers

Value of blood oxygenation level-dependent magnetic resonance imaging in early evaluation of the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: A preliminary study

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