Four New Pterosins from Pteris cretica and Their Cytotoxic Activities

Abstract

Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-β-d-glucopyranoside (4), together with five known pterosins 5–9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1 and 3 were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds 1 and 2 exhibited cytotoxic activity against HCT-116 cells with IC50 value of 22.4 μM and 15.8 μM, respectively.

The fern CYPome: Fern-specific cytochrome P450 family involved in convergent evolution of chemical defense

“…Ferns synthesize a diverse array of different natural products (Cooper-Driver et al, 1977; Alonso-Amelot, 2002; Kisielius et al, 2020) and it is highly likely that members of the CYP981 family catalyze some of the biosynthetic steps in these pathways. For example, the specific diversification of the CYP981 family in Pteridaceae, and the family-specific E, M and F CYP subfamilies, may be involved in the metabolic specialization of cytotoxic pterosins (Alonso-Amelot, 2002; Rasmussen, 2003; Lu et al, 2019). Further elucidation of natural product pathways in ferns shall clarify the degree of convergent evolution and neofunctionalization.…”

Antiproliferative Illudalane Sesquiterpenes from the Marine Sediment Ascomycete Aspergillus oryzae

“…Illudalane sesquiterpenes, obtained from different sources, have been reported to possess several biological properties, with a special focus on anticancer activities [25,26]. This prompted us to evaluate the antiproliferative activity of compounds 1-5 against three human cancer cell lines, namely, lung carcinoma (A549), liver carcinoma (HepG2), and breast carcinoma (MCF7).…”