“…Pharmaceuticals 2023, 16, x FOR PEER REVIEW 3 of 32 additional coumarins such as phenylcoumarins (5) [22][23][24]. Coumarins 1 (2H-chromen-2one or 2H-1-benzopyran-2-one), secondary metabolites that belong to the family of benzopyrones, are found in a variety of plant parts, such as roots, seeds, nuts, flowers, and fruit [25,26]. It has been established that compounds possessing a coumarin moiety have exhibited a variety of intriguing and exciting activities due to their varying pharmacological properties, such as anti-bacterial activity [4,24,25], anti-cancer [4,25,26], anti-coagulant [4,27], anti-oxidant [28], anti-fungal [4,[29][30][31], anti-tubercular [4,32,33] and most importantly for this research, anti-viral and anti-HIV activity [4,34,35].…”