Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

Kennedy, Alan R.; Khalaf, Abedawn I.; Scott, Fraser J.; Suckling, Colin J.

doi:10.1107/s2056989017001177

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Suckling et al have recently reported four nitropyrrole-based compounds (conjugates 44 – 47 , Fig. 9 ) as building blocks for the synthesis of novel minor groove binders [ 110 ]. Crystal structure data revealed that nitro groups and ester moieties in conjugates 44 and 45 are coplanar with the pyrrole ring, whereas the isopropyl fragment in conjugate 46 lies out of the pyrrole plane.…”

Section: Reviewmentioning

confidence: 99%

An overview of recent advances in duplex DNA recognition by small molecules

Bhaduri

Ranjan

Arya

2018

Beilstein J. Org. Chem.

111

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As the carrier of genetic information, the DNA double helix interacts with many natural ligands during the cell cycle, and is amenable to such intervention in diseases such as cancer biogenesis. Proteins bind DNA in a site-specific manner, not only distinguishing between the geometry of the major and minor grooves, but also by making close contacts with individual bases within the local helix architecture. Over the last four decades, much research has been reported on the development of small non-natural ligands as therapeutics to either block, or in some cases, mimic a DNA–protein interaction of interest. This review presents the latest findings in the pursuit of novel synthetic DNA binders. This article provides recent coverage of major strategies (such as groove recognition, intercalation and cross-linking) adopted in the duplex DNA recognition by small molecules, with an emphasis on major works of the past few years.

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Section: Reviewmentioning

confidence: 99%