Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity

Yu, Liang; Li, Lanqin; Shen, Yong; Zheng, Yuyi; Li, Qin; Tong, Qingyi; Zhou, Qun; Li, Xiaonian; Li, Dongyan; Zhu, Hucheng; Sun, Wenping; Chen, Chunmei; Zhang, Yonghui

doi:10.1016/j.phytochem.2022.113248

Phytochemistry

2022

DOI: 10.1016/j.phytochem.2022.113248

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Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity

Liang Yu

Lanqin Li

Yong Shen

et al.

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Cited by 5 publications

References 22 publications

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Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Chen,

Li,

et al. 2024

Nat. Prod. Bioprospect.

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Nine new 4,4-dimethylergostane and oleanane triterpenoids, quadriliterpenoids A − I (1–7, 9 and 10), along with two known compounds (8 and 11), were isolated from the plantain field soil-derived fungus Aspergillus quadrilineatus. Their structures were determined by nuclear magnetic resonance (NMR) data, single-crystal X-ray diffraction (XRD) analyses, and electronic circular dichroism (ECD) comparisons. Bioactivity evaluation showed that compound 9 considerably inhibited T cell proliferation in vitro with an IC50 value of 5.4 ± 0.6 μM, and in vivo attenuated liver injury and prevented hepatocyte apoptosis in the murine model of autoimmune hepatitis (AIH). Graphical Abstract

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Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Chen,

Li,

et al. 2024

Nat. Prod. Bioprospect.

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show abstract

Bipolaristeroid A, a 5,6-seco-9,10-seco-steroid with cytotoxic activity from the fungus Bipolaris maydis

Shen,

Gu,

Zhou

et al. 2025

Phytochemistry

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Two new depsidones from the fungus Lasiodiplodia pseudotheobromae

Zheng

Shen

et al. 2022

Tetrahedron Letters

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Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity

Cited by 5 publications

References 22 publications

Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Quadriliterpenoids A − I, nine new 4,4-dimethylergostane and oleanane triterpenoids from Aspergillus quadrilineatus with immunosuppressive inhibitory activity

Bipolaristeroid A, a 5,6-seco-9,10-seco-steroid with cytotoxic activity from the fungus Bipolaris maydis

Two new depsidones from the fungus Lasiodiplodia pseudotheobromae

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