Fourier Transform Infrared Spectroscopic Studies of Human Serum Albumin Microcapsules Prepared by Interfacial Cross-linking with Terephthaloylchloride: Influence of Polycondensation pH on Spectra and Relation with Microcapsule Morphology and Size

Lévy, M.-C.; Lefebvre, Sandrine; Rahmouni, Miloud; Andry, M.-C.; Manfait, Michel

doi:10.1002/jps.2600800617

Cited by 16 publications

(17 citation statements)

References 16 publications

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“…Nowadays artificial capsules can be produced in large quantities by first creating an emulsion and then adding a cross-linking agent to form a membrane around the droplets (Chang et al 1966;Lévy et al 1991Lévy et al , 1994Lévy et al , 1995Edwards-Lévy et al 1993Andry et al 1996). This results in the fabrication of capsules that are approximately spherical in shape.…”

Section: Introductionmentioning

confidence: 99%

Off-plane motion of a prolate capsule in shear flow

2013

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The objective of this study is to investigate the motion of an ellipsoidal capsule in a simple shear flow when its revolution axis is initially placed off the shear plane. We consider prolate capsules with an aspect ratio of two or three enclosed by a membrane, which is either strain-hardening or strain-softening. We seek the equilibrium motion of the capsule as we increase the capillary number $\mathit{Ca}$, which measures the ratio between the viscous and elastic forces. The three-dimensional fluid–structure interaction problem is solved numerically by coupling a boundary integral method (for the internal and external flows) with a finite element method (for the wall deformation). For any initial inclination with the flow vorticity axis, a given capsule converges towards a unique equilibrium configuration which depends on $\mathit{Ca}$. At low capillary number, the stable equilibrium motion is the rolling regime: the capsule aligns its long axis with the vorticity axis, while the membrane tank-treads. As $\mathit{Ca}$ increases, the capsule takes a complex wobbling motion at equilibrium, precessing around the vorticity axis. As $\mathit{Ca}$ is further increased, the capsule long axis oscillates about the shear plane, while the membrane rotates around a capsule cross-section that also oscillates over time (oscillating–swinging regime). The amplitude of the oscillations about the shear plane decreases as $\mathit{Ca}$ increases and the capsule finally takes a swinging motion in the shear plane. It is found that the transitions from rolling to wobbling and from wobbling to oscillating–swinging depend on the mean energy stored in the membrane.

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Section: Introductionmentioning

confidence: 99%

Off-plane motion of a prolate capsule in shear flow

2013

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“…The method of interfacial cross-linking originated from that of interfacial polycondensation and also involves the Schotten-Baumann reaction. The process involves a bifunctional monomer containing active hydrogen atoms which, during encapsulation, are replaced by a biopolymer, such as a protein [ 102 ]. At the interface of the emulsion, the membrane of the microcapsule is formed by the reaction of an acid chloride with the functional groups of the protein.…”

Section: Microencapsulation Methodsmentioning

confidence: 99%

Microencapsulation for the Therapeutic Delivery of Drugs, Live Mammalian and Bacterial Cells, and Other Biopharmaceutics: Current Status and Future Directions

Tomaro-Duchesneau

Saha

Malhotra

et al. 2013

Journal of Pharmaceutics

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Microencapsulation is a technology that has shown significant promise in biotherapeutics, and other applications. It has been proven useful in the immobilization of drugs, live mammalian and bacterial cells and other cells, and other biopharmaceutics molecules, as it can provide material structuration, protection of the enclosed product, and controlled release of the encapsulated contents, all of which can ensure efficient and safe therapeutic effects. This paper is a comprehensive review of microencapsulation and its latest developments in the field. It provides a comprehensive overview of the technology and primary goals of microencapsulation and discusses various processes and techniques involved in microencapsulation including physical, chemical, physicochemical, and other methods involved. It also summarizes the state-of-the-art successes of microencapsulation, specifically with regard to the encapsulation of microorganisms, mammalian cells, drugs, and other biopharmaceutics in various diseases. The limitations and future directions of microencapsulation technologies are also discussed.

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“…Morphology and microencapsulation process study Levy et al (1991) and Argillier et al (2002) Notes: a Acronyms were used to save on space. Refer to the list of acronyms.…”

Section: -Severalmentioning

confidence: 99%

“…TGA curves can provide differences between capsule-forming material and form microcapsules in composition, as well as the effect of capsule-forming material concentration on capsule composition. Chemical structures were measured by nuclear magnetic resonance (NMR), matrix-assisted laser desorption ionisationtime of flight mass spectrometry (MALDI-TOF), Fourier-transform infrared spectroscopy (FTIR) (Levy et al, 1991;Zydowicz et al, 2001;Boutti et al, 2005) and elemental analysis. The main component throughout the degradation of capsules can be determined via NMR (Rosenbauer et al, 2010).…”

Section: Thermal Properties and Chemical Structures Of Capsules' Shellmentioning

confidence: 99%

Characterisation and applications of microcapsules obtained by interfacial polycondensation

Zhang

Rochefort

2012

Journal of Microencapsulation

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This review highlights the materials, mechanisms and applications of microencapsulation by interfacial polycondensation in different areas. This technology entraps active ingredients inside microcapsules/microspheres, having an average diameter ranging from nanosize to several 100 µ. Polycondensation reactions take place at the boundary of two phases to form the shells of microcapsules or matrix microspheres. The emulsion can be classified into three types: water-in-oil, oil-in-water and oil-in-oil. According to the hydrophilic-lipophilic property of core phase, different active substances, such as proteins, enzymes, insecticides, herbicides, vitamins, catalysts, drugs, essential oils, dyes and phase change materials, have been successfully incorporated into different microcapsules/microspheres. Based on the shell-forming materials, this technology is capable of preparing polyamine, polyurea, polyurethane, polythiourea, polyester, polyepoxide, polyacrylamide and polysiloxane microcapsules. Over the past two decades, microcapsules prepared by interfacial polycondensation have been widely used in carbonless paper, cosmetics, pharmacy, agriculture, energy storage/transfer, thermal insulation/regulation and information and magnetic recording.

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Fourier Transform Infrared Spectroscopic Studies of Human Serum Albumin Microcapsules Prepared by Interfacial Cross-linking with Terephthaloylchloride: Influence of Polycondensation pH on Spectra and Relation with Microcapsule Morphology and Size

Cited by 16 publications

References 16 publications

Off-plane motion of a prolate capsule in shear flow

Off-plane motion of a prolate capsule in shear flow

Microencapsulation for the Therapeutic Delivery of Drugs, Live Mammalian and Bacterial Cells, and Other Biopharmaceutics: Current Status and Future Directions

Characterisation and applications of microcapsules obtained by interfacial polycondensation

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