Foveal and Macular Thickness Evaluation by Spectral OCT SLO and Its Relation with Axial Length in Various Degree of Myopia

Samuel, Nancy Elizabeth; Srikanth, Krishnamoorthy

doi:10.7860/jcdr/2015/11780.5676

Cited by 8 publications

(19 citation statements)

References 17 publications

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“…This finding was similar to that of a previous study [14]. In other studies, however, the increased foveal retinal thickness was significant [4,6,7,[11][12][13]16,[22][23][24], which could be due to the foveal elevation secondary to the mechanical stretching and pararetinal thinning in myopic eyes and the foveal retinal pigment epithelium's high permeability [6,10,[12][13][14]16,23,24]. Additionally, the absence of large vessels and optic fibers make the peripheral retina less resistant to stretching, while the foveal thickness is preserved [4,7,13,14,16].…”

Section: E Fsupporting

confidence: 90%

Macular Microvasculature in High Myopia without Pathologic Changes: An Optical Coherence Tomography Angiography Study

Min

Al-Qattan

Lee

et al. 2020

Korean J Ophthalmol

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To investigate macular microvasculature changes using optical coherence tomography angiography (OCTA) and analyze their correlation with the structural parameters in highly myopic eyes. Methods: We measured the area of the foveal avascular zone (FAZ) and the parafoveal vessel density in the superficial and deep retinal plexuses using OCTA. The magnification effect of the FAZ area was corrected using Bennett's formula. Retinal thickness measured at each corresponding area of the OCTA parameters, subfoveal choroidal thickness, and ocular characteristics were reviewed, and the relationships between the microvasculature measurements and the ocular structural characteristics were explored. Results: Fifty-two eyes with high myopia and 52 normal sex-and age-matched controls were included in the analysis. The FAZ area was significantly larger in the myopic eyes (p = 0.023). The superficial parafoveal vascular density was significantly decreased (p = 0.007) in the myopic eyes compared with the normal eyes, whereas there was no significant difference in the deep parafoveal vascular density (p = 0.226). Regarding the retinal thickness, only the parafoveal inner retinal thickness was significantly smaller in the myopic eyes than in the normal eyes (p = 0.023). The FAZ and subfoveal choroidal thickness were significantly correlated with the axial length, and the parafoveal inner retinal thickness was significantly correlated with the superficial parafoveal vascular density (all p < 0.05). Conclusions: The FAZ was enlarged and the parafoveal vascular density was reduced in the highly myopic eyes. The decrease was prominent in the superficial capillary plexuses and well-correlated with the retinal thickness profiles. The macular microvascular network alteration may be attributed to the ocular axial elongation that occurs with myopia.

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Section: E Fsupporting

confidence: 90%

Macular Microvasculature in High Myopia without Pathologic Changes: An Optical Coherence Tomography Angiography Study

Min

Al-Qattan

Lee

et al. 2020

Korean J Ophthalmol

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“…Increased foveal thickness in myopic eyes has been reported in other studies [ 10 – 14 , 23 ]. Tangential traction by the ILM or posterior vitreous cortex was hypothesized to be one of the reasons, whereas Luo suggested that increased foveal thickness might be caused by the high permeability of the RPE at the fovea [ 12 , 24 ].…”

Section: Discussionsupporting

confidence: 75%

“…Detecting such changes in macular thickness by Fourier-domain OCT is helpful in understanding clinical findings in myopic eyes, and further studies for the mechanism underneath might help us to find ways to treat or even prevent the complications in highly myopic eyes. Also our results together with others [ 8 – 14 , 21 , 23 – 26 ] implied that caution must be taken when interpreting data of retinal thickness of different area as well as different layers of the macula measured by OCT in highly myopic eyes.…”

Section: Discussionsupporting

confidence: 68%

Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

et al. 2015

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BackgroundTo explore the changes in thickness in different areas and layers of the macula under different refractive conditions.MethodsConsecutive participants were enrolled in the study. Optical coherence tomography (OCT) images were obtained using a spectral-domain system. We studied the relationships of the full, inner and outer retinal thicknesses of the fovea, parafovea and perifovea relative to the spherical equivalent (SE) and axial length (AL).ResultsWe included 107 eyes; the analysis revealed that the men had thicker foveas (man vs women: 236.70 ± 18.97 μm vs 247.25 ± 16.70 μm P = 0.002) and inner parafoveas (man vs women: 128.35 ± 8.80 μm vs 122.78 ± 6.75 μm P < 0.001) than the women had. Full foveal thickness was not correlated with AL or SE (all P > 0.05), whereas the full para- and perifoveal thicknesses had significant negative correlations with AL (r = –0.243 P = 0.006 and r = –0.446 P < 0.001, for para- and peri- respectively) and positive correlations with SE (r = 0.346 P < 0.001 and r = 0.464 P < 0.001, for para- and peri- respectively). Regarding the layers, the thickness of the inner layer of the fovea increased with the degree of myopia. The average inner and outer layer thicknesses of the para- and perifovea decreased with the degree of myopia (with the SE para, b = 0.307, peri b = 0.457; with the AL para, b = –0.266, peri b = –0.454),with the perifoveal thicknesses decreasing more rapidly.ConclusionsMacular thickness changes with the degree of myopia; however, the different areas and different layers change in different manners.Electronic supplementary materialThe online version of this article (doi:10.1186/s12886-015-0080-5) contains supplementary material, which is available to authorized users.

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“…Recent studies have reported that the foveal thickness of myopic patients is thicker than that in emmetropia patients and increases with progression of myopia [43, 44]. Although the present study showed no significant differences of foveal thicknesses, because there was no significant difference in myopia, parafoveal retinal thickness was associated with β -PPA, which may be attributed in part to the difference in mGCIPL thicknesses.…”

Section: Discussioncontrasting

confidence: 73%

Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopicβ-Zone Parapapillary Atrophy

Kwon

Choi

Kim

et al. 2016

Journal of Ophthalmology

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Purpose. To assess the correlations of myopic β-zone parapapillary atrophy (β-PPA) with the optic nerve head (ONH) and retina. Methods. We selected 27 myopic patients who showed prominent β-PPA in one eye and no β-PPA in the other eye. We studied their macula, macular ganglion cell-inner plexiform layer (mGCIPL), peripapillary retinal nerve fiber layer (pRNFL) thickness, and ONH parameters using optical coherence tomography. Results. The average of five out of six sectors and minimum values of mGCIPL thicknesses in eyes with prominent β-PPA discs were significantly less than those of the control eyes. The results of clock-hour sector analyses showed significant differences for pRNFL thickness in one sector. In the ONH analyses, no significant difference was observed between myopic β-PPA and control eyes. The macular thickness of the β-PPA eyes was thinner than control eyes in all sectors. There was a significant difference between the two groups in three sectors (the inner superior macula, inner temporal macula, and inner inferior macula) but there was no significant difference in the other sectors, including the fovea. Conclusions. The myopic β-PPA eyes showed thinner mGCIPL, parafovea, and partial pRNFL layers compared with myopic eyes without β-PPA.

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Foveal and Macular Thickness Evaluation by Spectral OCT SLO and Its Relation with Axial Length in Various Degree of Myopia

Cited by 8 publications

References 17 publications

Macular Microvasculature in High Myopia without Pathologic Changes: An Optical Coherence Tomography Angiography Study

Macular Microvasculature in High Myopia without Pathologic Changes: An Optical Coherence Tomography Angiography Study

Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopicβ-Zone Parapapillary Atrophy

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