Foveal avascular zone in normal human eyes by optical coherence tomography angiography

Pang, Yunlei; Zhang, Guoqiang; Zhang, Han; She, Jie; Zhang, Xiaoguang; Li, Huixia; Zhang, Guisen

doi:10.1016/j.pdpdt.2023.103303

Cited by 3 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the FAZ is affected, it can lead to different levels of visual impairment. 32 It has been demonstrated that a larger FAZ area is linked to more severe capillary occlusion and nonperfusion in the macular region of the retina. 33 A recent study has indicated that in cases of diabetic retinopathy, the enlargement of the FAZ is among the earliest signs that significantly correlate with visual acuity and the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus: Assessed by optical coherence tomography angiography

Liu,

Zhang,

et al. 2023

Lupus

View full text Add to dashboard Cite

Objective The aim was to investigate the changes in retinal and choroidal thickness and vascular density in patients with systemic lupus erythematosus (SLE) using optical coherence tomography angiography (OCTA). Methods Twenty-nine patients with SLE (29 eyes) and 25 control subjects (25 eyes) were enrolled. SLE activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Retinal thickness (RT), inner retinal thickness (IRT), outer retinal thickness (ORT), choroidal thickness (ChT), retinal superficial vascular density (SVD), retinal deep vascular density (DVD), choriocapillary vascular density (CCVD), foveal avascular zone (FAZ), superficial FAZ (sFAZ), and deep FAZ (dFAZ) were measured using OCTA. The retinal and choroidal thickness and vascular density between the control group and SLE group were compared. The relationships between SLEDAI scores and the retinal and choroidal thickness and vascular density in SLE group were analyzed. Results The SVD was significantly increased, and the DVD and CCVD were significantly decreased in the SLE group compared to the control group ( p < .05). The results of receiver operating characteristic (ROC) showed that the area under the curve (AUC) values of SVD, DVD, and CCVD were 0.873, 0.729, and 0.727, indicating a high accuracy in discriminating patients with SLE from controls. Correlation analysis showed that the SLEDAI scores were positively correlated with dFAZ ( r = 0.589, p = .001) and FAZ ( r = 0.451, p = .018), and negatively correlated with DVD ( r = −0.491, p = .009) and CCVD ( r = −0.521, p = .005). Conclusions DVD and CCVD were decreased in the SLE and might be related to the disease activity. SVD, DVD, and CCVD may hold promise in the discovery of biomarkers for diagnosing SLE.

show abstract

Section: Discussionmentioning

confidence: 99%