Foveal Microstructure and Functional Parameters in Lamellar Macular Hole

Reibaldi, Michele; Parravano, Mariacristina; Varano, Monica; Longo, Antonio; Avitabile, Teresio; Uva, Maurizio G.; Zagari, Marco; Toro, Mario Damiano; Boscia, Francesco; Boccassini, Barbara; Chiaravalloti, Adele; Mariotti, Cesare; Reibaldí, A.

doi:10.1016/j.ajo.2012.06.008

Cited by 42 publications

(36 citation statements)

References 37 publications

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“…These results are in agreement with Reibaldi et al who recently reported that the integrity of the photoreceptor layer correlates with BCVA and central retinal sensitivity 26. Moreover, in our study a reduction of BCVA and macular sensitivity was also observed in LMH eyes with ELM abnormalities compared to eyes with preserved ELM.…”

Section: Discussionsupporting

confidence: 93%

Functional and structural assessment of lamellar macular holes

et al. 2012

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Section: Discussionsupporting

confidence: 93%

Functional and structural assessment of lamellar macular holes

et al. 2012

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“…The ICC is a separate measure of correlation between graders that takes into account the differences in individual ratings [26]. Previous studies have suggested that these two statistics provide two different types of information regarding agreement, and both were used to increase the confidence in our assessments [26,27,28]. The results of our study show good repeatability and suggest that this method could be an objective way to analyze the RPE line.…”

Section: Discussionsupporting

confidence: 55%

Correlation of Preoperative Retinal Pigment Epithelium Status with Foveal Microstructure in Repaired Macular Holes

et al. 2014

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Purpose: To investigate, with spectral-domain optical coherence tomography, if the preoperative status of the retinal pigment epithelium (RPE) affects the postoperative foveal morphology and visual outcomes in eyes with surgically closed macular holes (MHs). Methods: In 52 eyes with surgically closed MHs, preoperative RPE morphology was evaluated and graded based on the measurement of the largest hyperreflective protrusions above the RPE line. Foveal microstructural features and best-corrected visual acuity (BCVA) were evaluated 12 months after surgery. Results: At 12 months, a significant correlation was found between postoperative degree of integrity of the photoreceptors with preoperative RPE morphology, and base diameter of the hole (p = 0.003 and p = 0.028, respectively); mean BCVA at 12 months in eyes with diffuse RPE alteration was significantly lower than in eyes with small or no RPE alteration (p < 0.05). Conclusions: Preoperative RPE integrity may be indicative of good photoreceptor restoration and visual recovery in patients with surgically closed MHs.

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“…89 Maintenance of VA in eyes with lamellar macular holes is associated with preservation of the ELM. 90 As with macular pseudoholes, vitrectomy with ILM peeling may be performed in patients with impaired VA or symptomatic distortion—optimal results are obtained when the IS/OS junction and ELM are intact. 91, 92 …”

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confidence: 99%

Idiopathic vitreomacular traction and macular hole: a comprehensive review of pathophysiology, diagnosis, and treatment

Steel

Lotery

2013

Eye

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Posterior vitreous detachment (PVD) is a common phenomenon in the aging eye. However, this may be complicated by persistent symptomatic vitreomacular adhesions that exert tractional forces on the macula (vitreomacular traction; VMT). VMT itself may be associated with epiretinal membrane formation and the development of idiopathic macular holes (IMH). Such pathologies may cause visual disturbances, including metamorphopsia, photopsia, blurred vision, and decreased visual acuity, which impact an individual's quality of life. Technologies such as optical coherence tomography allow an increasingly more accurate visualisation of the macular anatomy, including quantification of macular hole characteristics, and this facilitates treatment decision-making. Pars plana vitrectomy remains the primary treatment option for many patients with VMT or IMH; for the latter, peeling of the inner limiting membrane (ILM) of the retina has shown improved outcomes when compared with no ILM peeling. The development of narrow-gauge transconjunctival vitrectomy systems has improved the rate of visual recovery following surgery. Ocriplasmin, by degrading laminin and fibronectin at the vitreoretinal interface, may allow induction of PVD in a non-invasive manner. Indeed, clinical studies have supported its use as an alternative to surgery in certain patient populations. However, further research is still needed with respect to greater understanding of the pathophysiology underlying the development of VMT and IMH.

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Foveal Microstructure and Functional Parameters in Lamellar Macular Hole

Cited by 42 publications

References 37 publications

Functional and structural assessment of lamellar macular holes

Functional and structural assessment of lamellar macular holes

Correlation of Preoperative Retinal Pigment Epithelium Status with Foveal Microstructure in Repaired Macular Holes

Idiopathic vitreomacular traction and macular hole: a comprehensive review of pathophysiology, diagnosis, and treatment

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