FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGβ1

Paylakhi, Seyed Hassan; Moazzeni, Hamidreza; Yazdani, Shahin; Rassouli, Paniz; Arefian, Ehsan; Jaberi, Elham; Arash, Emad Heidari; Gilani, Ahmad Sadighi; Fan, Jian‐Bing; April, Craig; Amin, Sadaf; Suri, Fatemeh; Elahi, Elahe

doi:10.1016/j.exer.2013.03.009

Cited by 46 publications

(42 citation statements)

References 55 publications

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“…Moreover, miR-133 was found to inhibit pituitary adenoma cell invasion and migration and induce EMT by directly targeting FOXC1 [39]. Besides contributing to tumorigenesis, as a target of miR-204, FOXC1 was also confirmed in the trabecular meshwork related to the miR-204-MEIS2 (myeloid ecotropic viral integration site 1 homolog 2) regulatory pathway [40, 41]. MEIS2 is a homeobox transcription factor, which exerts multiple functions in vertebrate eye development and has been earlier identified as a miR-204 target [42].…”

Section: Fox-related Mirnasmentioning

confidence: 99%

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Zhang

Chen

et al. 2016

Oncotarget

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Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment.

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Section: Fox-related Mirnasmentioning

confidence: 99%

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Zhang

Chen

et al. 2016

Oncotarget

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“…Recently, it has also been reported that miR-204 caused decreased expression of FOXC1 and the FOXC1 target genes CLOCK, PLEKHG5, ITGB1, and MEIS2 in TM cell cultures. 63 The inhibition of FOXC1 by miR-204 is potentially relevant in the TM since mutations in this gene are among the causes of AxenfeldRieger syndrome, which is often accompanied by elevated intraocular pressure (IOP). 64,65 These results support the concept that miR-204 might play a relevant role in the TM and that alterations in expression of this miRNA could contribute to pathogenic changes.…”

mentioning

confidence: 99%

Role of MicroRNAs in the Trabecular Meshwork

González

Qiu

et al. 2014

Journal of Ocular Pharmacology and Therapeutics

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MicroRNAs (miRNAs) are now recognized as important post-transcriptional regulators of gene expression. MiRNAs are known to modulate cellular functions relevant to the normal and pathological physiology of the trabecular meshwork (TM) such as cell contraction and extracellular matrix turnover. There is also increasing evidence supporting the role of miRNAs in the pathogenesis of multiple diseases, and their potential value as both biomarkers of disease and therapeutic targets. However, compared with other tissues, our current knowledge regarding the roles played by miRNAs in the TM is still very limited. Here, we review the information currently available about miRNAs in the TM and discuss the main challenges and opportunities to incorporate the rapid progress in miRNA biology to the understanding of the normal and pathological physiology of the TM, and to develop novel clinical applications for diagnosis and therapy of high intraocular pressure.

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“…However, the major disease burden is the high risk of glaucoma due to the changes in eye morphogenesis, which develops in approximately 50% of ARS patients due to malformations in aqueous humor drainage structures (Paylakhi et al, 2013). Glaucoma may develop during childhood (developmental glaucoma), but it is more common during adolescence or at the beginning of adulthood (early-onset glaucoma).…”

Section: Introductionmentioning

confidence: 99%

Whole exome sequencing reveals a novel de novo FOXC1 mutation in a patient with unrecognized Axenfeld–Rieger syndrome and glaucoma

Pasutto

Mauri

Popp

et al. 2015

Gene

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FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGβ1

Cited by 46 publications

References 55 publications

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers

Role of MicroRNAs in the Trabecular Meshwork

Whole exome sequencing reveals a novel de novo FOXC1 mutation in a patient with unrecognized Axenfeld–Rieger syndrome and glaucoma

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