FOXD1‐AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression

Ma, Yuxin; Han, Jingchao; Luo, Xi

doi:10.1111/odi.14002

Cited by 12 publications

(7 citation statements)

References 38 publications

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“…50,51 These lncRNAs can regulate the stability of downstream genes by binding to RBPs. 52,53 After screening the potential RBPs that could interact with the validated lncRNAs, we discovered that HNRNPU has a relatively high interaction propensity with NONHSAG039942, NONHSAG071405, and LXLOC_058190, which was also at a core interactive position with other RBPs that present high binding ability with these lncRNAs.…”

Section: Discussionmentioning

confidence: 99%

Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans

Tang

Zhang

Liu

et al. 2023

The Journal of Gene Medicine

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Background The potential function of long non‐coding RNAs (lncRNAs) in human hepatic ischemia–reperfusion injury (HIRI) remains to be clarified. Methods Clinical samples of transplanted liver tissues from 26 patients undergoing liver transplantation (LT) and normal liver tissues from seven patients undergoing hepatic hemangiomactomy (Con) were collected. Typical samples were subjected to whole transcriptome sequencing (RNA‐seq). Differentially expressed genes between groups were identified by DEGseq and were analyzed by enrichment analysis including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis. Transcription of five lncRNAs including NONHSAG039942, NONHSAG071405, NONHSAG027516, LXLOC_058190, and LXLOC_024376 that presented significant difference in RNA‐sequencing were validated by a quantitative real‐time PCR (qRT‐PCR), for which the subcellular localization and the binding ability to known human RNA‐binding proteins (RBPs) were respectively predicted by LncLocator and catRAPID genomics v2.1. Results We identified 2917 lncRNAs and 2811 mRNAs that were differentially expressed (p < 0.05 and log2 fold change > 1 or < −1) between groups (LT vs. Con). NONHSAG039942, NONHSAG071405, LXLOC_058190, and LXLOC_024376 were validated by qRT‐PCR to be significantly increased in the LT group, and were all predicted to be localized in cytoplasm or cytosol. NONHSAG039942, NONHSAG071405, and LXLOC_058190 held an RBP interaction propensity score of 98.07%, 76.95%, and 152.99%, respectively, with heterogeneous‐nuclear ribonucleoprotein U (HNRNPU). Pathways significantly activated in transplant livers that involved HNRNPU as a core enrichment gene included hypoxia, ACE2 expression, apoptosis, spliceosome formation, etc. Conclusions NONHSAG039942, NONHSAG071405, and LXLOC_058190 were significantly increased in transplant livers after reperfusion and their role in HIRI may be associated with HNRNPU, a core protein that participates in hypoxia and chromatin accessibility.

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Section: Discussionmentioning

confidence: 99%

Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans

Tang

Zhang

Liu

et al. 2023

The Journal of Gene Medicine

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“…LncRNAs have been described to interact with their nearby genes in the modulation of cancer cells [ 28 , 29 ]. In our research, SOX21 was verified to be the nearby gene of SOX21-AS1, and it was positively regulated by SOX21-AS1 in PC cells.…”

Section: Discussionmentioning

confidence: 99%

SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21

Yu¹,

Zhao²,

Wang³

et al. 2022

J Transl Med

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Background Pancreatic cancer (PC) is a highly malignant tumor which threatens human’s health. Long non-coding RNAs (lncRNAs) are implicated in many cancers, including PC, but their mechanisms in PC have not yet been entirely clarified. We focused on revealing the potential function of lncRNA SOX21-AS1 in PC. Methods Functional assays assessed SOX21-AS1 function on PC progression. Bioinformatics analysis, along with mechanism assays were taken to unmask the regulatory mechanism SOX21-AS1 may exert in PC cells. Results SOX21-AS1 possessed a high expression level in PC cells. SOX21-AS1 absence suppressed PC cell proliferation, migration, stemness and epithelial-mesenchymal transition (EMT) while elevated cell apoptosis. SOX21-AS1 positively regulated its nearby gene SRY-box transcription factor 21 (SOX21) at post-transcriptional level. Through mechanism assays, we uncovered that SOX21-AS1 sponged SOX21-AS1 to elevate SOX21 mRNA and recruited ubiquitin-specific peptidase 10 (USP10) to deubiquitinate and stabilize SOX21 protein. Moreover, signal transducer and activator of transcription 6 (STAT6) could transcriptionally activate SOX21-AS1 and SOX21 expression. Conclusions SOX21-AS1 aggravated the malignant development of PC, which might provide the utility value for PC treatment.

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“… 57 Furthermore, FOXD1-AS1 has been reported to express at a high level in OSCC and promote the malignant phenotypes via regulating the stability of FOXD1. 58 Other studies have focused on DANCR, which is dramatically upregulated in human NPC and can bind to RNA-binding protein 3 and stabilize SOX2 mRNA, resulting in NPC cell proliferation. 59 Besides, DANCER can also increase HIF-1α mRNA stability by interacting with NF90/NF45, leading to NPC metastasis and disease progression.…”

Section: Mechanism Of Lncrnas In Hnsccmentioning

confidence: 99%

The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma

Jiang

Liu

Yang

et al. 2022

Molecular Therapy - Oncolytics

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Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands, and thyroid. However, the molecular mechanisms underlying the carcinogenesis of head and neck squamous cell carcinomas (HNSCCs) remain poorly understood. Over the past decades, overwhelming evidence has demonstrated the regulatory roles of long non-coding RNAs (lncRNAs) in tumorigenesis, including HNSCC. Notably, these lncRNAs have vital roles in gene regulation and affect various aspects of cellular homeostasis, including proliferation, survival, and metastasis. They exert regulating functions by interacting with nucleic acids or proteins and affecting cancer cell signaling. LncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of lncRNAs in HNSCC. In this review, we summarize the deregulation and function of lncRNAs in human HNSCC. We also review the working mechanism of lncRNAs in HNSCC pathogenesis and discuss the potential application of lncRNAs as diagnostic/prognostic tools and therapeutic targets in human HNSCC.

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FOXD1‐AS1 upregulates FOXD1 to promote oral squamous cell carcinoma progression

Cited by 12 publications

References 38 publications

Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans

Functional analysis of hepatic long non‐coding ribonucleic acids during liver transplantation in humans

SOX21-AS1 activated by STAT6 promotes pancreatic cancer progression via up-regulation of SOX21

The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma

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