FOXO3A Expression in Upper Tract Urothelial Carcinoma

Zhang, Guoyao; Shi, Wanping; Jia, Enzhao; Zhang, Lei; Han, Yongsheng; Rodríguez, Ronald; Ma, Tianjiang

doi:10.3389/fonc.2021.603681

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Forkhead box O3A (FOXO3A), which belongs to the FOXO protein family and is located on human chromosome 6q21, is usually involved in DNA damage repair, cell cycle regulation, apoptosis, and the cell stress response as an important transcriptional regulator. Downregulation of FOXO3A expression may promote the occurrence, metastasis, and progression of UTUC [ 33 ]. François et al used targeted next-generation sequencing to prospectively sequence tumors and found a significant correlation between the risk of bladder recurrence after radical surgery for UTUC and mutations in FGFR3, KDM6A, CCND1, and TP53 [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of subsequent bladder cancer on survival in upper tract urothelial carcinoma patients post-radical nephroureterectomy: a systematic review and meta-analysis

Hu,

Lai,

Wang

et al. 2023

BMC Urol

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Background Radical nephroureterectomy (RNU) is the primary treatment strategy for upper tract urothelial carcinoma (UTUC). However, the intravesical recurrence occurs in 20–50% of all patients. The specific effect of subsequent bladder cancer (SBCa) on survival remains unclear. Therefore, we investigated the effect of SBCa following RNU in patients with UTUC. Methods PubMed, EMBASE, and Cochrane Library were exhaustively searched for studies comparing oncological outcomes between SBCa and without SBCa. Standard cumulative analyses using hazard ratios (HR) with 95% confidence intervals (CI) were performed using Review Manager (version 5.3). Results Five studies involving 2057 patients were selected according to the predefined eligibility criteria. Meta-analysis of cancer-specific survival (CSS) and overall survival (OS) revealed no significant differences between the SBCa and non-SBCa groups. However, subgroup analysis of pT0-3N0M0 patients suggested that people with SBCa had worse CSS (HR = 5.13, 95%CI 2.39–10.98, p < 0.0001) and OS (HR = 4.00, 95%CI 2.19–7.31, p < 0.00001). Conclusions SBCa appears to be associated with worse OS in patients with early stage UTUC. However, caution must be taken before recommendations are made because this interpretation is based on very few clinical studies and a small sample size. Research sharing more detailed surgical site descriptions, as well as enhanced outcome data collection and improved reporting, is required to further investigate these nuances.

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Section: Discussionmentioning

confidence: 99%

Effect of subsequent bladder cancer on survival in upper tract urothelial carcinoma patients post-radical nephroureterectomy: a systematic review and meta-analysis

Hu,

Lai,

Wang

et al. 2023

BMC Urol

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“…The flowchart for study selection in this meta-analysis is presented in Figure 1. The literature retrieval process obtained 21 eligible articles, 14,15,17,19,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] encompassing 4058 cancer patients, published from 2008 to 2021. The mean of sample size was 193, ranging from 60 to 934 patients.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…13 Overexpression of FOXO3a is associated with poor prognosis in triple-negative breast cancer, 14 hepatocellular carcinoma, 15 glioblastoma, 16 and upper tract urothelial carcinoma. 17 IT is also correlated with unfavorable clinicopathological features such as advanced tumor node metastasis (TNM) stages, histological grades, and vessel invasion. In addition, tumors with highly expressed FOXO3a appear to be more prone to metastasis.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of high FOXO3a expression in patients with solid tumors: A meta-analysis and systematic review

Wang

Jiang³

et al. 2022

Int J Biol Markers

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Background FOXO3a (previously termed FKHRL1), plays an evolutionarily conserved role in the control of biological process, including DNA damage, apoptosis, and cell cycle regulation. However, the role of FOXO3a in tumors remains controversial. This meta-analysis was conducted to evaluate the prognostic value of FOXO3a expression in patients with solid tumors. Methods A systematic literature search of the PubMed, Web of Science, Embase, and Cochrane Library databases was performed. Eligible publications on FOXO3a and cancer prognosis were collected and screened according to the eligibility criteria. The combined odds ratios (ORs) or hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were used to assess the prognostic value of FOXO3a. Stata 12.0 software was used for statistical analysis. Results A total of 4058 patients from 21 articles on a variety of solid tumors were included. Meta-analysis showed that the increased FOXO3a expression level was associated with longer overall survival (HR = 0.62; 95% CI: 0.46–0.85). The pooled ORs indicated high expression level of FOXO3a in tumors was significantly associated with lymph node metastasis (OR = 0.46; 95% CI: 0.30–0.71), TNM stage (OR = 0.37; 95% CI: 0.25–0.54), tumor differentiation (OR = 0.46; 95% CI: 0.26–0.80), distant metastasis (OR = 0.44; 95% CI: 0.32–0.61), and age (OR = 1.28; 95% CI: 1.08–1.51). However, we did not observe a significant correlation between the high expression of FOXO3a and sex or tumor size. Conclusions The high expression level of FOXO3a was associated with better clinical outcomes in solid tumors. FOXO3a may therefore serve as a potential prognostic biomarker and a promising molecular target.

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Lymph Node Dissection in Upper Tract Urothelial Carcinoma: Current Status and Future Perspectives

Dłubak,

Karwacki,

Logoń

et al. 2023

Curr Oncol Rep

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Purpose of Review This narrative review aims to evaluate the role of lymph node dissection (LND) in upper tract urothelial carcinoma (UTUC) and its implications for staging and management outcomes, as well as future perspectives. Recent Findings Multiple studies have demonstrated the limitations of conventional imaging techniques in accurately localizing lymph node metastasis (LNM) in UTUC. While 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18FDG-PET/CT) shows promise for preoperative LNM detection, its specificity is low. Alternative methods such as choline PET/CT and sentinel lymph node detection are under consideration but require further investigation. Additionally, various preoperative factors associated with LNM hold potential for predicting nodal involvement, thereby improving nodal staging and oncologic outcomes of LND. Several surgical approaches, including segmental ureterectomy and robot-assisted nephroureterectomy, provide a possibility for LND, while minimizing morbidity. Summary LND remains the primary nodal staging tool for UTUC, but its therapeutic benefit is still uncertain. Advances in imaging techniques and preoperative risk assessment show promise in improving LNM detection. Further research and multi-center studies are needed to comprehensively assess the advantages and limitations of LND in UTUC, as well as the long-term outcomes of alternative staging and treatment strategies.

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FOXO3A Expression in Upper Tract Urothelial Carcinoma

Cited by 5 publications

References 38 publications

Effect of subsequent bladder cancer on survival in upper tract urothelial carcinoma patients post-radical nephroureterectomy: a systematic review and meta-analysis

Effect of subsequent bladder cancer on survival in upper tract urothelial carcinoma patients post-radical nephroureterectomy: a systematic review and meta-analysis

Prognostic value of high FOXO3a expression in patients with solid tumors: A meta-analysis and systematic review

Lymph Node Dissection in Upper Tract Urothelial Carcinoma: Current Status and Future Perspectives

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