FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos, Kelma; Franscisconi, Carolina F; Okehie, Valerie; Souza, Letícia Chaves de; Trombone, Ana Paula; Letra, Ariadne; Garlet, Gustavo; Gomez, Ricardo Santiago; Silva, Renato

doi:10.1016/j.joen.2014.10.003

Cited by 39 publications

(47 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In phase 2, the full-text of 18 studies were retrieved and evaluated. Of those, only eight 14,15,16,17,18,19,20,21 met the eligibility criteria. No additional study was identified in the reference lists of the included articles and in the grey literature.…”

Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…14,15,18,21 All studies involved human periapical lesion fragments. Samples of six articles 14,15,18,19,20,21 were obtained directly through surgery and samples of the other two studies were obtained through institutional archives collected from previous surgical procedures. 16,17 Fou r a r t icles repor ted t he mea n age of participants 18,19,20,21 and five studies defined the range between 17 and 64 years.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…16,17 Fou r a r t icles repor ted t he mea n age of participants 18,19,20,21 and five studies defined the range between 17 and 64 years. 14,15,19,20,21 The language of the articles was predominantly English, although the studies were conducted in different countries (Brazil, United States and Serbia). The analytical method used in two studies was the ELISA method.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

View full text Add to dashboard Cite

The process involved in periapical lesions, which occur as an outcome of pulpal necrosis, is regulated by the immune system including regulatory T cells (Treg) and T helper 17 cell (Th17) responses. The objective of this study was to conduct a frequency systematic review to determine the presence of Treg/Th17 responses and the influence of these cells in the progression of chronic inflammatory periapical lesions in humans. A systematic computerized search was carried out in Pubmed, Medline, Web of Science and Scopus electronic databases from their date of inception through the first week of May 2017. In addition, the reference lists of the included articles and the grey literature were hand-searched. Articles that evaluated the presence and influence of Treg/Th17 in the progression of human periapical lesions were included. Study selection and the quality assessment of the included articles (using the Newcastle-Ottawa scale) were carried out by two authors. Fifty-seven titles/abstracts were screened and eight studies met the eligibility criteria and were included in this systematic review. The included studies showed large variation in the type of periapical lesion assessed, mean age, age range, type of experiment and findings regarding the participation of Th17 and Treg in the status of inflammatory periapical lesions. The studies showed the involvement of Treg in the modulation of the inflammatory response in radicular cysts and periapical granulomas. This systematic review highlights the relationship between Treg and Th17 acting in a subtle balance inhibiting or promoting the progression of human periapical lesions.

show abstract

Section: Study Selectionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Treg and Th17 cells in inflammatory periapical disease: a systematic review

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Some evidences suggested that MMPs are involved in AP development and play an important role in the pulp and periapical tissue destruction during inflammation process (16). In particular, MMP2 and MMP9 expression has been consistently reported in AP (16,17).…”

Section: Introductionmentioning

confidence: 99%

MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to evaluate the expression of MMP2 and MMP9 during apical periodontitis (AP) progression in TLR2 (TLR2 KO) and in MyD88 (MyD88 KO) knockout mice compared to wild type (WT) mice. AP was induced in mandibular first molars of TLR2 KO (n= 18), MyD88 KO (n= 18), and WT mice (n= 18). After 7, 21, and 42 days, the animals were euthanized and the jaws were dissected and subjected to histotechnical processing. Subsequent sections were stained by immunohistochemistry and evaluated for detection of MMP2 and MMP9. Statistical analysis of the semi-quantitative analysis of immunohistochemistry was performed using chi-square test (α = 0.05). In the initial periods of AP progression, an increased expression of MMP9 in the TLR2 KO and MyD88 KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 expression in the TLR2 KO mice were observed. MMP2 and MMP9 production was modulated for TLR2 and MyD88 during apical periodontitis progression. MMP2 and MMP9 are Associated w i t h A p i c a l P e r i o d o n t i t i s P r o g r e s s i o n a n d M i g h t b e Modulated by TLR2 and MyD88

show abstract

Endodontic Infections and Systemic Disease

Fouad¹

2017

Endodontic Microbiology

View full text Add to dashboard Cite

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Cited by 39 publications

References 34 publications

Treg and Th17 cells in inflammatory periapical disease: a systematic review

Treg and Th17 cells in inflammatory periapical disease: a systematic review

MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88

Endodontic Infections and Systemic Disease

Contact Info

Product

Resources

About