FOXP3 lymphocyte status may predict the risk of malignant transformation in oral leukoplakia

Malignant transformation of oral leukoplakia: Systematic review and meta‐analysis of the last 5 years

“…The proportion of MT was found to be variable among different studies (Table 1), ranging between 1.1% and 40.8% (Chaturvedi et al, 2019;del Corso et al, 2015;Farah et al, 2019;Gandara-Vila et al, 2018;Gopinath et al, 2016;Jayasooriya et al, 2020;Kuribayashi et al, 2015;Li et al, 2020;Lima et al, 2016;Mogedas et al, 2015;Monteiro et al, 2017;Mustafa et al, 2019;Qasrdashti et al, 2017;Sakata et al, 2020;Shearston et al, 2019;Sundberg et al, 2020;Tsai et al, 2017;Wang et al, 2018Wang et al, , 2019Watabe et al, 2016;Wu et al, 2018Wu et al, , 2019Zhang et al, 2017a;Zhang et al, 2017b). Following meta-analysis, the pooled proportion of MT was 9.8% (95% CI: 7.9-11.7; p <.001; Figure 2a).…”

“…Lastly, since 168 articles did not analyze the malignant transformation of OL, 26 did not provide sufficient information and 1 was not an observational study, only 20 cohort studies, which accounted for 0.7% of the articles, were identified in the first search (Chaturvedi et al, 2019;del Corso et al, 2015;Farah et al, 2019;Gandara-Vila et al, 2018;Gopinath et al, 2016;Kuribayashi et al 2015;Lima et al, 2016;Mogedas-Vegara et al, 2015;Monteiro et al, 2017;Mustafa et al, 2019;Qasrdashti et al, 2017;Shearston et al, 2019;Tsai et al, 2017;Wang et al, 2018;Wang et al, 2019;Watabe et al, 2016;Wu et al, 2018;Wu et al, 2019;Zhang et al, 2017a;Zhang et al, 2017b). Also, four additional studies were included through manual searches (Jayasooriya et al, 2020;Li et al, 2020;Sakata et al, 2020;Sundberg et al, 2020).…”

“…Most studies also reported the follow-up time of the OL patients (Chaturvedi et al, 2019;del Corso et al, 2015;Farah et al, 2019;Gandara-Vila et al, 2018;Gopinath et al, 2016;Jayasooriya et al, 2020;Kuribayashi et al, 2015;Li et al, 2020;Lima et al, 2016;Mogedas-Vegara et al, 2015;Monteiro et al, 2017;Sakata et al, 2020;Shearston et al, 2019;Tsai et al, 2017;Wang et al, 2018Wang et al, , 2019Watabe et al, 2016;Wu et al, 2018Wu et al, , 2019Zhang et al, 2017a;Zhang et al, 2017b). This period was very variable (1.8 to 21.6 years).…”

“…Information regarding age and gender was available in 21 studies (Table 2) older/ younger than 50 years (Gopinath et al, 2016;Jayasooriya et al, 2020;Mustafa et al, 2019;Qasrdashti et al, 2017;Sundberg et al, 2020;Wang et al, 2019), (b) in groups of patients older/ younger than 55 years Zhang et al, 2017b), (c) in groups of patients older/ younger than 60 years (Gandara-Vila et al, 2018;Kuribayashi et al, 2015;Wu et al, 2019), (d) in groups of patients older/ younger than 65 years (Sakata et al, 2020), and (e) calculating the average age del Corso et al, 2015;Farah et al, 2019;Mogedas-Vegara et al, 2015;Monteiro et al, 2017;Shearston et al, 2019;Tsai et al, 2017;Watabe et al, 2016;Wu et al, 2018). After re-grouping the results, the majority of malignancies occurred in people older than 50 years (82.5%).…”

“…Tobacco and alcohol habits of the patients who underwent malignant transformation were investigated in 16 studies (Table 2) (Farah et al, 2019;Gandara-Vila et al, 2018;Gopinath et al, 2016;Jayasooriya et al, 2020;Li et al, 2020;Lima et al, 2016;Mogedas-Vegara et al, 2015;Mustafa et al, 2019;Qasrdashti et al, 2017;Shearston et al, 2019;Sakata et al, 2020;Tsai et al, 2017;Wang et al, 2019;Wu et al, 2018;Zhang et al, 2017b). Our review shows that 42.4% of them were smokers and 26.3% were alcohol consumers (Table 2).…”