2006
DOI: 10.1093/carcin/bgi347
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Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells

Abstract: The anti-cancer efficacy of grape seed extract (GSE) against prostate cancer (PCA) via its anti-proliferative, pro-apoptotic and anti-angiogenic activities in both cell culture and animal models have recently been described by us. GSE is a complex mixture containing gallic acid (GA), catechin (C), epicatechin (EC) and several oligomers (procyanidins) of C and/or EC, some of which are esterified to GA. To determine which components are most active against PCA, an ethyl acetate extract of GSE was separated by re… Show more

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Cited by 163 publications
(128 citation statements)
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“…Previous studies have indicated that gallic acid, as an anti-oxidant agent, can inhibit the growth of PC cells through activating apoptosis (24). In this study, gallic acid especially in IC50 not only decreased DU-145 cells viability, but also changed the morphology of these cells (Figures 1 and 2), which is in agreement with other investigators (25). Also, many studies have shown that gallic acid is an anti-cancer agent with cytotoxic effects against DU-145 cells.…”
Section: Discussionsupporting
confidence: 93%
“…Previous studies have indicated that gallic acid, as an anti-oxidant agent, can inhibit the growth of PC cells through activating apoptosis (24). In this study, gallic acid especially in IC50 not only decreased DU-145 cells viability, but also changed the morphology of these cells (Figures 1 and 2), which is in agreement with other investigators (25). Also, many studies have shown that gallic acid is an anti-cancer agent with cytotoxic effects against DU-145 cells.…”
Section: Discussionsupporting
confidence: 93%
“…Hydroxybenzoic acids, such as gallic and ellagic acids as well as other polyphenolic molecules possess cytotoxic activity on human cancer cells (Zhang et al 2005, Veluri et al 2006). In addition, other researches have reported that plants with polyphenolic substances (for instance, flavonoids) protect the cells against injury caused by X-rays, block the progression of the cell cycle and prostaglandin synthesis, inhibit mutations and prevent carcinogenesis in experimental animals (Abdulla and Gruber 2000).…”
Section: Antitumor Activitymentioning
confidence: 99%
“…Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a naturally occurring plant phenol, is abundant in natural plants (15)(16)(17)(18)(19) and it has been reported to have anti-bacterial (20), anti-viral (21), anti-inflammatory (16), antioxidant (22) and antitumor functions in many human cancer cell lines (21)(22)(23). Although GA has been shown to inhibit the growth of prostate cancer cells, there is no available information addressing GA-inhibited migration and invasion of prostate cancer cells in vitro.…”
Section: Introductionmentioning
confidence: 99%