Fracture Callus in Osteopetrosis

Palma, Luigi de; Tulli, A; Maccauro, Giulio; Sabetta, S P; Torto, M del

doi:10.1097/00003086-199411000-00014

Cited by 44 publications

(34 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many operative treatment modalities (Table 2) have been described in the past as having considerable difficulties and complications [4,5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Kleinberg [15] treated a peritrochanteric fracture with plate, screws and a cortical strut graft.…”

Section: Discussionmentioning

confidence: 99%

Fixation of Subtrochanteric Fractures in Two Patients with Osteopetrosis Using a Distal Femoral Locking Compression Plate of the Contralateral Side

et al. 2009

View full text Add to dashboard Cite

Osteopetrosis or Albers-Schönberg disease is a rare inherited skeletal disorder characterized by increased osteodensity and modeling defects. The fragility of such dense bone may lead to an increased incidence of fractures, especially on the hip and proximal femur. These fractures can pose problems during surgery, as the bones are hard and no medullary cavity is available for intramedullary nailing. Here we report our experience of two sisters who both presented with a subtrochanteric fracture that was fixed using a distal femoral locking compression plate (DF-LCP; Synthes, Obedors, Switzerland) of the contralateral side.

show abstract

Section: Discussionmentioning

confidence: 99%

Fixation of Subtrochanteric Fractures in Two Patients with Osteopetrosis Using a Distal Femoral Locking Compression Plate of the Contralateral Side

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Histologically, mature osteopetrotic fracture callus contains no Haversian organization and has a paucity of osteoclasts [17]. Although the mechanical strength of osteopetrotic bone is decreased, at least one study in rats suggests there is no difference in the elastic modulus or hardness as compared with normal bone [24].…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of these fractures has been described in the literature mostly in the form of case reports and small case series (Tables 1, 2). This body of evidence repeatedly reports the difficulties associated with operative treatment, including the extreme hardness of the bone, which impedes drilling and cutting, hardware failure, periprosthetic fractures, coxa vara deformity, delayed union, pseudarthrosis, refracture, and periprosthetic infection [3,5,6,12,13,17,21,27,29,35,38,43]. When comparing all forms of operative treatment in studies that report time to union, the average time to union is approximately 26 weeks.…”

Section: Discussionmentioning

confidence: 99%

Case Reports: Treatment of Subtrochanteric and Ipsilateral Femoral Neck Fractures in an Adult with Osteopetrosis

Birmingham

McHale

2008

Clin Orthop Relat Res

View full text Add to dashboard Cite

We describe a patient with autosomal-dominant osteopetrosis, a subtrochanteric fracture, and an ipsilateral femoral neck fracture treated with a hip spica cast Although the fracture united with coxa vara and external rotation deformities, the patient successfully returned to his normal activities of daily living. Operative fracture treatment in patients with osteopetrosis is difficult, and our patient provides evidence that with nonoperative treatment these patients can return to a functional level when operative treatment is not an option.

show abstract

“…These can fail to replace fracture callus with lamellar bone to cause some healing problems of fractures, autografts, allografts, xenografts, osteotomies, and arthrodeses (Frost, 1998c)**. That same failure impairs bone healing in osteopetrosis (Bollerslev, 1989;De Palma et al, 1994). Failure to replace primary spongiosa with secondary spongiosa causes one kind of osteopetrosis (Jaffe, 1972).…”

Section: Some Remodeling Functionsmentioning

confidence: 99%

“…The possibility that cigarette smoking might impair a RAP, and thus bone healing too, seems to deserve study (Cook et al, 1997). The osteoclast defect that causes osteopetrosis impairs replacement of fracture callus with lamellar bone ("B" above) (de Palma et al, 1994), which should help to explain impaired bone healing in that disease**.…”

Section: Implications For Bone Healing In Fractures Bone Grafts Ostmentioning

confidence: 99%

From Wolff's law to the Utah paradigm: Insights about bone physiology and its clinical applications

2001

View full text Add to dashboard Cite

Efforts to understand our anatomy and physiology can involve four often overlapping phases. We study what occurs, then how, then ask why, and then seek clinical applications. In that regard, in 1960 views, bone's effector cells (osteoblasts and osteoclasts) worked chiefly to maintain homeostasis under the control of nonmechanical agents, and that physiology had little to do with anatomy, biomechanics, tissue-level things, muscle, and other clinical applications. But it seems later-discovered tissue-level mechanisms and functions (including biomechanical ones, plus muscle) are the true key players in bone physiology, and homeostasis ranks below the mechanical functions. Adding that information to earlier views led to the Utah paradigm of skeletal physiology that combines varied anatomical, clinical, pathological, and basic science evidence and ideas. While it explains in a general way how strong muscles make strong bones and chronically weak muscles make weak ones, and while many anatomists know about the physiology that fact depends on, poor interdisciplinary communication left people in many other specialties unaware of it and its applications. Those applications concern 1.) healing of fractures, osteotomies, and arthrodeses; 2.) criteria that distinguish mechanically competent from incompetent bones; 3.) design criteria that should let load-bearing implants endure; 4.) how to increase bone strength during growth, and how to maintain it afterwards on earth and in microgravity situations in space; 5.) how and why healthy women only lose bone next to marrow during menopause; 6.) why normal bone functions can cause osteopenias; 7.) why whole-bone strength and bone health are different matters; 8.) why falls can cause metaphyseal and diaphyseal fractures of the radius in children, but mainly metaphyseal fractures of that bone in aged adults; 9.) which methods could best evaluate whole-bone strength, "osteopenias" and "osteoporoses"; 10.) and why most "osteoporoses" should not have bone-genetic causes and some could have extraosseous genetic causes. Clinical specialties that currently require this information include orthopaedics, endocrinology, radiology, rheumatology, pediatrics, neurology, nutrition, dentistry, and physical, space and sports medicine. Basic science specialties include absorptiometry, anatomy, anthropology, biochemistry, biomechanics, biophysics, genetics, histology, pathology, pharmacology, and cell and molecular biology. This article reviews our present general understanding of this new bone physiology and some of its clinical applications and implications. It must leave to other times, places, and people the resolution of questions about that new physiology, and to understand the many devils that should lie in its details. (Thompson D'Arcy, 1917). Anat Rec 262: 2001.

show abstract

Fracture Callus in Osteopetrosis

Cited by 44 publications

References 0 publications

Fixation of Subtrochanteric Fractures in Two Patients with Osteopetrosis Using a Distal Femoral Locking Compression Plate of the Contralateral Side

Fixation of Subtrochanteric Fractures in Two Patients with Osteopetrosis Using a Distal Femoral Locking Compression Plate of the Contralateral Side

Case Reports: Treatment of Subtrochanteric and Ipsilateral Femoral Neck Fractures in an Adult with Osteopetrosis

From Wolff's law to the Utah paradigm: Insights about bone physiology and its clinical applications

Contact Info

Product

Resources

About