Fracture fixation problems in osteoporosis

Strømsøe, Knut

doi:10.1016/j.injury.2003.08.019

Cited by 107 publications

(78 citation statements)

References 12 publications

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“…The fractures responsible for the late peak are often considered 'osteoporotic fractures,' 'fragility fractures,' or 'J-Type fractures' (Melton, 1995;Strømsøe, 2004). These fractures are distinguished epidemiologically by representative characteristics, specifically: connection with moderate trauma at sites containing significant quantities of trabecular bone; incidence rates that increase with age; and prevalence is higher among females than males (Melton, 1995).…”

Section: Introductionmentioning

confidence: 99%

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Hip fractures in the Portuguese archaeological record

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Lopes

et al. 2011

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Fractures are ubiquitous in the archaeological record but the majority of these are the consequence of a traumatic incident and do not reflect any loss of strength inherent to the bone. So-called fragility fractures, particularly hip fractures, are considered uncommon occurrences in skeletal populations from the past. Nevertheless, evidence of this type of fracture in the archaeological record is increasing. A methodical search for possible hip fractures in the excavation reports, theses and monographs housed in the Department of Anthropology of the University of Coimbra presented an occasion to describe six hip fractures, previously unpublished, from different Portuguese archaeological sites and to challenge the widespread assumption that hip fractures were nearly non-existent in the past.

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Section: Introductionmentioning

confidence: 99%

“…It is widely accepted that osteoporosis is the main cause of reduced bone strength, and epidemiological data indicate that low bone mineral density (BMD) values are related with an increased risk of fraction at the population level (Melton, 1995;Marcus, 1996;Grynpas, 2003;Strømsøe, 2004;Sievänen et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Hip fractures in the Portuguese archaeological record

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Lopes

et al. 2011

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“…Bone mass loss, or loss of mineral content per unit of volume, along with trabecular deterioration, contributes to bone fragility and increased propensity to fracture (Strømsøe, 2004). Notwithstanding, generalized decrease of bone mass without fractures associated is usually identified as osteopenia (Marcus, 1996).…”

Section: Introductionmentioning

confidence: 99%

A 14th–17th century osteoporotic hip fracture from the Santa Clara‐a‐Velha Convent in Coimbra (Portugal)

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Lopes

Cunha

2009

Intl J of Osteoarchaeology

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Osteoporosis is an evocative term for a metabolic disorder characterized by loss of bone mass and organization, which predisposes to fracture. The clinical consequences of osteoporosis lie in the problems associated with it, specifically hip, Colles and vertebral fractures. We present here an extracapsular fracture of the proximal femur in an aged female skeleton from the Santa Clara-a-Velha Monastery (14th-17th centuries) in Coimbra, Portugal. This fracture is probably secondary to an osteoporotic disorder. Bone remodeling at the fracture site confirms that this woman survived for a long period after sustaining a fracture of the proximal femur, suggestive of a solid community assistance and support.

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“…Osteoporosis is a disease manifested by drastic bone loss resulting in osteopenia and high fracture risk [16,17]. Previous investigations have discovered that osteoporosis may lead to decrease in BMSCs' organelles, reduction of BMSCs' viability, differentiation of BMSCs into adipocytes and decreased proliferation of BMSCs in vitro [5,18].…”

Section: Discussionmentioning

confidence: 99%

Improvement of intertrochanteric bone quality in osteoporotic female rats after injection of polylactic acid-polyglycolic acid copolymer/collagen type I microspheres combined with bone mesenchymal stem cells

Zhu

et al. 2012

International Orthopaedics (SICOT)

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Purpose Osteoporosis mainly involves cancellous bone, and the spine and hip, with their relatively high cancellous bone to cortical bone ratio, are severely affected. Studies of bone mesenchymal stem cells (BMSCs) from osteoporotic patients and animal models have revealed that osteoporosis is often associated with reduction of BMSCs' proliferation and osteogenic differentiation. Our aim was to test whether polylactic acidpolyglycolic acid copolymer(PLGA)/collagen type I(CoI) microspheres combined with BMSCs could be used as injectable scaffolds to improve bone quality in osteoporotic female rats. Methods PLGA microspheres were coated with CoI. BMSCs of the third passage and were cultured with PLGA/CoI microspheres for seven days. Forty three-month-old female non-pregnant SD rats were ovariectomized to establish osteoporotic animal models. Three months after being ovariectomized, the osteoporotic rats were randomly divided into five groups: SHAM group, PBS group, cell group, microsphere (MS) group, and cell+MS group. Varying materials were injected into the intertrochanters of each group's rats. Twenty rats were sacrificed at one month and three months post-op, respectively. The femora were harvested in order to measure the intertrochanteric bone mineral density (BMD) with DEXA and trabecular thickness (Tb.Th), percentage of trabecular area (%Tb.Ar), bone volume fraction (BV/TV) and trabecular spacing (Tb.Sp) with Micro CT. One-way ANOVA and Kruskal-Wallis tests were used. Results BMSCs seeded on PLGA/CoI microspheres had a nice adhesion and proliferation. At one month post-op, the BMD (0.33 ± 0.01 g/cm 2 ), Tb.Th (459.65 ± 28.31 μm), %Tb.Ar (9.61±0.29 %) and Tb.Sp (2645.81±94.91 μm) of the cell+MS group were better than those of the SHAM group and the cell group. At three months post-op, the BMD (0.32±0.01 g/cm 2 ), Tb.Th (372.81±38.45 μm), %Tb.Ar (6.65 ± 0.25 %), BV/TV (6.62 ± 0.25 %) and Tb.Sp (1559.03±57.06 μm) of the cell+MS group were also better than those of the SHAM group and the cell group. Conclusion The PLGA/CoI microspheres combined with BMSCs can repair bone defects more quickly. This means that PLGA/CoI microspheres combined with BMSCs can promote trabecular reconstruction and improve bone quality in osteoporotic rats. This scaffold can provide a promising minimally invasive surgical tool for enhancement of bone fracture healing or prevention of fracture occurrence which will in turn minimize complications endemic to patients with osteoporosis.

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Fracture fixation problems in osteoporosis

Cited by 107 publications

References 12 publications

Hip fractures in the Portuguese archaeological record

Hip fractures in the Portuguese archaeological record

A 14th–17th century osteoporotic hip fracture from the Santa Clara‐a‐Velha Convent in Coimbra (Portugal)

Improvement of intertrochanteric bone quality in osteoporotic female rats after injection of polylactic acid-polyglycolic acid copolymer/collagen type I microspheres combined with bone mesenchymal stem cells

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