Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

Chen, Guofang; Chen, Ruoyao; Zou, Chunxiao; Yang, Danwen; Chen, Zhe‐Sheng

doi:10.1039/c3tb21512a

Cited by 36 publications

(29 citation statements)

References 32 publications

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“…Since the inner diameter of nanotubes is not easily controllable, this inability can cause the thickness of the wall to vary. Despite this, the prepared nanotubes are still characterized by a uniformity in their dimension, and are flexible to adjust on command13. As revealed by TEM, the oleic acid modified Fe 3 O 4 nanoparticles are about 5 nm in size (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The AAO/magnetic PS composite membrane was removed from the microscope slide and polished by 1000 grit sand paper. Afterwards it was submerged in the 3 M sodium hydroxide solution to dissolve the template and to expose the Fe 3 O 4 @PS nanotubes131733.…”

Section: Methodsmentioning

confidence: 99%

“…As an exciting class of one-dimensional nanomaterials with a large specific surface area, polymer nanotubes have been assessed for their potential applications in a wide variety of fields such as optoelectronic nanodevices, chemical sensors, and drug delivery610. Recently, polymer nanotubes have become the preferred drug delivery nanovehicles not only because they offer an enhanced drug loading capacity and stability, but also because they exhibit a good potential for surface modification and provide excellent pharmacokinetic control111213. However, it is still a challenge to fabricate organic nanotubes with a controllable film thickness and diameter using the facile technique10.…”

mentioning

confidence: 99%

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Fabrication of Sesame Sticks-like Silver Nanoparticles/Polystyrene Hybridnanotubes and Their Catalytic Effects

Peng

Wang

Shi

et al. 2016

Sci Rep

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A novel and efficient catalyst is one of the goals in the material field, and the involvement of nanoscience and technology has brought new vigor to the development of catalyst. This research aimed to develop a simple two-step route to fabricate Fe3O4@PS/PDA-Ag hybridnanotubes with size-controllable and highly dispersed silver nanoparticles (NPs). First, Fe3O4@PS nanotubes of a sound mechanical property were prepared using polystyrene (PS)/toluene solution containing highly dispersed oleic acid modified Fe3O4 particles in a commercial AAO template. Next, the facile technique was used to form in situ silver NPs on the surface of magnetic PS (Fe3O4@PS) nanotubes through dopamine coating. The catalytic effects of the prepared Fe3O4@PS/PDA-Ag hybridnanotubes with highly dispersed AgNPs were characterized using a range of analytical methods, including transmission electron microscopy, thermogravimetric analysis, UV-Visible spectroscopy, and X-ray diffraction. It was found that such prepared Fe3O4@PS/PDA-Ag hybridnanotubes had a large specific surface area. They possessed excellent activities in catalyzing the reduction of 4-nitrophenol (4-NP) by NaBH4 in the aqueous phase. Furthermore, they were readily separated from fluid and retrieved by an external magnet. Their catalyst activity and recyclability demonstrated that this approach we proposed had the potential to become a new idea and route for catalytic platform.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Fabrication of Sesame Sticks-like Silver Nanoparticles/Polystyrene Hybridnanotubes and Their Catalytic Effects

Peng

Wang

Shi

et al. 2016

Sci Rep

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“…The authors reported suitable chemotherapy for MDA MB231 breast cancer. Chen et al [153] prepared long polymer nanotubes with cross linked poly(glycidyl methacrylate) and a pendant poly(N-isopropyl acrylamide) for delivery of anti-cancer drugs. The authors used doxorubicin as a model drug for the study.…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

et al. 2020

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Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

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“…They also demonstrated that above the LCST (37 °C), the nanotubes remain open sufficiently long enough for the activation of proficient drug release. Below the LCST (25 °C), the gates were in a closing state with no drug release until the activation temperature was once again reached [ 40 ].…”

Section: Overview Of the Properties And Functionality Of Diverse Tmentioning

confidence: 99%

A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents

et al. 2016

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Abstract:There has been an exponential increase in research into the development of thermal-and ultrasound-activated delivery systems for cancer therapy. The majority of researchers employ polymer technology that responds to environmental stimuli some of which are physiologically induced such as temperature, pH, as well as electrical impulses, which are considered as internal stimuli. External stimuli include ultrasound, light, laser, and magnetic induction. Biodegradable polymers may possess thermoresponsive and/or ultrasound-responsive properties that can complement cancer therapy through sonoporation and hyperthermia by means of High Intensity Focused Ultrasound (HIFU). Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation. Polyethylene oxide/polypropylene oxide co-block or triblock polymers and polymethacrylates are thermal-and pH-responsive polymer groups, respectively but both have proven to have successful activity and contribution in chemotherapy when exposed to ultrasound stimulation. This review focused on collating thermal-and ultrasound-responsive delivery systems, and combined thermo-ultrasonic responsive systems; and elaborating on the advantages, as well as shortcomings, of these systems in cancer chemotherapy. The mechanisms of these systems are explicated through their physical alteration when exposed to the corresponding stimuli. The properties they possess and the modifications that enhance the mechanism of chemotherapeutic drug delivery from systems are discussed, and the concept of pseudo-ultrasound responsive systems is introduced.

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Fragmented polymer nanotubes from sonication-induced scission with a thermo-responsive gating system for anti-cancer drug delivery

Abstract: Fragmented polymer nanotubes with a thermo-responsive gating system were prepared by a 2-fold “grafting-from” strategy and sonication-induced scission for efficient drug delivery. In vitro thermo-responsive DOX drug release and chemotoxicity were testified with such nanocarriers.

Cited by 36 publications

References 32 publications

Fabrication of Sesame Sticks-like Silver Nanoparticles/Polystyrene Hybridnanotubes and Their Catalytic Effects

Fabrication of Sesame Sticks-like Silver Nanoparticles/Polystyrene Hybridnanotubes and Their Catalytic Effects

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment

A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents

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