Fragmented QRS as a predictor of subclinical cardiovascular disease in patients with chronic kidney disease

Toraman, Aysun; Eren, Berna; Yılmaz, Ilknur; Düzgün, Fatih; Taneli, Fatma; Kürşat, Seyhun

doi:10.1111/imj.14743

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…In previous studies on patients with established structural heart disease or AF, the prevalence of fQRS has ranged between 30 and 50% and the rates have been similar among patients with CKD stage 3-5 [8,9,[19][20][21]. As with LAE, the high fQRS rate may partly be explained by the high rate of cardiovascular comorbidities in our study population since fQRS has been associated with diabetes, CAD and, vascular calcification in prior reports [8,18,22]. In recent studies, fQRS has been linked to the incidence of new-onset AF in patients with established heart disease, as well as to increased AF recurrence after cardioversion or catheter ablation [8,9,19,23,24].…”

Section: Discussionsupporting

confidence: 56%

Interatrial block, P terminal force or fragmented QRS do not predict new-onset atrial fibrillation in patients with severe chronic kidney disease

Hellman

Hakamäki

Lankinen

et al. 2020

BMC Cardiovasc Disord

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Background The prevalence of left atrial enlargement (LAE) and fragmented QRS (fQRS) diagnosed using ECG criteria in patients with severe chronic kidney disease (CKD) is unknown. Furthermore, there is limited data on predicting new-onset atrial fibrillation (AF) with LAE or fQRS in this patient group. Methods We enrolled 165 consecutive non-dialysis patients with CKD stage 4–5 without prior AF diagnosis between 2013 and 2017 in a prospective follow-up cohort study. LAE was defined as total P-wave duration ≥120 ms in lead II ± > 1 biphasic P-waves in leads II, III or aVF; or duration of terminal negative portion of P-wave > 40 ms or depth of terminal negative portion of P-wave > 1 mm in lead V1 from a baseline ECG, respectively. fQRS was defined as the presence of a notched R or S wave or the presence of ≥1 additional R waves (R’) or; in the presence of a wide QRS complex (> 120 ms), > 2 notches in R or S waves in two contiguous leads corresponding to a myocardial region, respectively. Results Mean age of the patients was 59 (SD 14) years, 56/165 (33.9%) were female and the mean estimated glomerular filtration rate was 12.8 ml/min/1.73m2. Altogether 29/165 (17.6%) patients were observed with new-onset AF within median follow-up of 3 [IQR 3, range 2–6] years. At baseline, 137/165 (83.0%) and 144/165 (87.3%) patients were observed with LAE and fQRS, respectively. Furthermore, LAE and fQRS co-existed in 121/165 (73.3%) patients. Neither findings were associated with the risk of new-onset AF within follow-up. Conclusion The prevalence of LAE and fQRS at baseline in this study on CKD stage 4–5 patients not on dialysis was very high. However, LAE or fQRS failed to predict occurrence of new-onset AF in these patients.

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Section: Discussionsupporting

confidence: 56%

Interatrial block, P terminal force or fragmented QRS do not predict new-onset atrial fibrillation in patients with severe chronic kidney disease

Hellman

Hakamäki

Lankinen

et al. 2020

BMC Cardiovasc Disord

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“…Haan et al, reported that women with leiomyoma have a worse cardiovascular disease risk profile, including higher blood pressure, higher fasting plasma cholesterol and glucose levels, and more asymptomatic organ damage 23 . Toraman et al, found fQRS to be a predictor of subclinical atherosclerosis in chronic kidney disease patients by looking at fQRS 24 . Fedulaev et al, found that the presence of fQRS in lateral derivations showed that it could be a non-invasive marker of severe coronary atherosclerosis 25 .…”

Section: Discussionmentioning

confidence: 99%

Association between uterine leiomyoma and fragmented QRS waves: a prospective case-control study

Tatlici,

Cetin,

Korpe

et al. 2024

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to evaluate the relationship between uterine leiomyoma and fragmented QRS, a non-invasive indicator of cardiovascular risk and myocardial ischemia, in women with uterine leiomyoma. METHODS: In this prospective case-control study, a total of 47 patients diagnosed with uterine leiomyoma (case group) and 47 healthy individuals without uterine leiomyoma (control group) who had undergone bilateral tubal ligation surgery were included. Various demographic, clinical, and laboratory parameters and the presence of fragmented QRS were recorded. RESULTS: The leiomyoma group showed significantly higher body mass index (27.46±2.18 vs. 25.9±2.87 kg/m 2 , p=0.005) and waist circumference (91.34±9.30 vs. 84.97±9.3 cm, p=0.001) compared with the control group. Uterine volumes were also significantly higher in the leiomyoma group (235.75±323.48 vs. 53.24±12.81 mm 3 , p<0.001). The presence of fragmented QRS was detected in 18.1% of the patients. Multiple regression analysis identified age, fasting blood glucose value, and the presence of fragmented QRS as independent risk factors for the presence of leiomyoma. CONCLUSION: This study provides valuable insights into the relationship between uterine leiomyoma and fragmented QRS. The presence of fragmented QRS was identified as an independent risk factor for the presence of leiomyoma. Further research is needed to better understand the underlying mechanisms connecting uterine leiomyoma and cardiovascular health.

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Relation between fragmented QRS complex and cardio-ankle vascular index in asymptomatic subjects

Akyüz

Şahin

Çırakoğlu

et al. 2021

Clinical and Experimental Hypertension

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Fragmented QRS as a predictor of subclinical cardiovascular disease in patients with chronic kidney disease

Cited by 3 publications

References 27 publications

Interatrial block, P terminal force or fragmented QRS do not predict new-onset atrial fibrillation in patients with severe chronic kidney disease

Interatrial block, P terminal force or fragmented QRS do not predict new-onset atrial fibrillation in patients with severe chronic kidney disease

Association between uterine leiomyoma and fragmented QRS waves: a prospective case-control study

Relation between fragmented QRS complex and cardio-ankle vascular index in asymptomatic subjects

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