Frailty and the biochemical effects of recombinant human growth hormone in women after surgery for hip fracture

Metabolism and catabolism in hip fracture patients: Nutritional and anabolic intervention—a review

“…This was in contrast to a recent 6 month-study with oral GH secretagogue given to hip fracture patients who reported no functional improvement from this treatment (Bach et al 2004) (Table). Moreover, there have been reports of serious side effects of GH treatment in acute critically ill patients (Takala et al 1999), but not in hip fracture patients when therapy was started 3-4 days postoperatively (Yeo et al 2003, Hedström et al 2004. Daily infusions of recombinant IGF-I/ IGFBP-3 complex for 2 months in hip fracture Table).…”

Translational Research on the Clinical Applications of Ghrelin

“…The age-related reduction in energy intake has been termed "the anorexia of aging" and predisposes to the development of under-nutrition, which has been implicated in the development and progression of chronic diseases commonly affecting the elderly, as well as in increasing mortality. Growth hormone therapy increases IGF-I levels, promotes anabolism and increases muscle strength in healthy elderly individuals, as well as in selected patient groups [48][49][50]. Therefore, ghrelin and GHS may also have therapeutic potential to assist in the recovery of frail patients who require nutritional support and conventional rehabilitation [51].…”

Fragilité, ostéoporose et fracture du col du fémur: causes, conséquences et perspectives thérapeutiques

“…Les sujets malades ont un taux bas d'IGF-1 malgré des concentrations élevées de GH [149]. La supplémentation en GH après fracture du col du fémur chez des sujets âgés conduit à une élévation sérique de l'hormone d'autant plus limitée que le sujet est malade [150]. Cette résistance périphérique à la GH n'est pas observée chez les sujets en forme [151].…”