Frailty, anemia and potential future biomarkers

Kapsokoulou, Athina; Dionyssiotis, Yannis

doi:10.22540/jfsf-04-029

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Previous studies [ 32 , 33 ] have also found that people with lower BMI have higher risks of frailty, subsequently increasing the risk of death [ 34 ]. Low haemoglobin levels (anaemia) have also been associated with a higher risk of developing frailty [ 35 – 37 ], similar to the results of the current study.…”

Section: Discussionsupporting

confidence: 89%

“…This study was approved by the Ethics Committees of Tokyo Medical and Dental University and Omihachiman Community Medical Center, and it was conducted in accordance with the ethical principles of the Declaration of Helsinki. All of the participants provided written informed consent (approval number M2018-021, [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46].…”

Section: Fundingmentioning

confidence: 99%

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Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study

et al. 2020

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Background: Chronic kidney disease (CKD) involves many factors that can cause frailty and oral hypofunction. We aimed to investigate the prevalence of frailty and oral hypofunction and to examine the associations among kidney function, frailty, and oral function in adults with CKD in Japan. Methods: This cross-sectional study was conducted at two institutions. The participants included 109 patients with CKD stages 3-5 who visited outpatient clinics or were admitted for inpatient treatment. Frailty was evaluated using the Japanese version of the Cardiovascular Health Study frailty criteria. Oral function was evaluated by assessing oral motor skills [oral diadochokinesis (ODK) rate], masticatory ability, and the repetitive saliva swallowing test. The estimated glomerular filtration rate (eGFR) was used to indicate kidney function. We examined the associations among kidney function, frailty, and oral function using binomial logistic regression analysis. Results: In total, 31 participants (28.4%) were classified as being frail. Univariate analysis showed that age, body mass index, eGFR, and haemoglobin level were significantly associated with frailty. ODK and swallowing function were significantly associated with frailty. Multivariate analysis revealed that frailty was significantly associated with eGFR [odds ratio (OR) 0.96, 95% confidence interval (CI) 0.92-1.00, p = 0.048] and ODK rate (OR 0.68, CI 0.47-0.98, p = 0.038). However, no significant association was found between CKD severity and masticatory or swallowing function. Conclusion: We found a high prevalence of frailty in patients with CKD and a significant association between frailty and oral motor skills, affecting the swallowing function of patients with nondialysis CKD. The high prevalence of frailty among patients with CKD suggests that routine assessment of frailty is necessary to prevent the development of severe complications. In addition, oral and kidney function should be carefully evaluated, and oral health education and interventions should be performed for patients with CKD.

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Section: Discussionsupporting

confidence: 89%

Section: Fundingmentioning

confidence: 99%

Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study

et al. 2020

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Mortality from all-cause and cause-specific in the elderly: Joint implications of anemia and frailty

Zhang,

Wei,

Chen

et al. 2023

Archives of Gerontology and Geriatrics

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Risk Factors for Prolonged Hospital Stay After Femoral Neck Fracture

Levitt¹,

Patch²,

Johnson³

et al. 2023

Orthopedics

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The purpose of this study was to investigate the association between pre-operative anemia and prolonged hospital stay among geriatric patients with operative femoral neck fractures. This retrospective cohort study was performed at a level I trauma center and included geriatric patients with femoral neck fractures (OTA/AO 31) and operative treatment with Current Procedural Terminology code 27236. Exclusion criteria were admission to the intensive care unit, evacuation of subdural hematoma, and conditions requiring exploratory laparotomy. A total of 207 individuals, with data collected between January 2015 and August 2019 and age 65 years and older, were included in the analysis. Linear regression was used to evaluate the association between anemia and length of stay adjusting for potential confounders. Anemia was defined using preoperative hematocrit. The primary outcome was prolonged length of stay, defined as 5 or more days. The group was 65% women. The mean age was 80.2 years (range, 64–98 years). The majority (61%) of patients had anemia. American Society of Anesthesiologists classification was associated with preoperative anemia ( P =.02). Patients with anemia had a 16% higher risk of prolonged length of stay compared with patients without anemia (81% vs 65%, P =.009). In the linear regression model, preoperative hematocrit was associated with length of stay ( P =.032) when adjusted for sex, age, preoperative tranexamic acid, preoperative hemoglobin, postoperative hemoglobin, and postoperative hematocrit. Length of stay was approximately 1 week in this study, with anemia being a statistically significant risk factor for prolonged length of stay. Health care providers and administrators can consider anemia on admission when predicting length of stay. [ Orthopedics . 202x;4x(x):xx–xx.]

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Frailty, anemia and potential future biomarkers

Cited by 3 publications

References 7 publications

Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study

Association among kidney function, frailty, and oral function in patients with chronic kidney disease: a cross-sectional study

Mortality from all-cause and cause-specific in the elderly: Joint implications of anemia and frailty

Risk Factors for Prolonged Hospital Stay After Femoral Neck Fracture

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