Frailty in relation to the risk of Alzheimer's disease, dementia, and death in older Chinese adults: A seven-year prospective study

Wang, C.; Ji, Xunming; Wu, Xia; Tang, Zhe; Zhang, X.; Guan, Shaochen; Liu, H.; Fang, Xianghua

doi:10.1007/s12603-016-0798-7

Cited by 22 publications

(16 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of reports suggesting changes in body and spleen weights (correlated with inflammatory signals), and the development of frailty in age-related dementias, such as AD [ 35 , 78 , 81 , 96 , 106 ], we evaluated the impact of stroke on these physiological parameters in aged hAPP-SL mice. However, we did not detect a significant difference in the body weights of both the stroke- and sham-operated hAPP-SL mice at pre- and post-surgery timepoints (Fig.…”

Section: Resultsmentioning

confidence: 99%

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Nguyen

Hayes

Zbesko

et al. 2018

acta neuropathol commun

View full text Add to dashboard Cite

The goal of this study was to determine the chronic impact of stroke on the manifestation of Alzheimer’s disease (AD) related pathology and behavioral impairments in mice. To accomplish this goal, we used two distinct models. First, we experimentally induced ischemic stroke in aged wildtype (wt) C57BL/6 mice to determine if stroke leads to the manifestation of AD-associated pathological β-amyloid (Aβ) and tau in aged versus young adult wt mice. Second, we utilized a transgenic (Tg) mouse model of AD (hAPP-SL) to determine if stroke leads to the worsening of pre-existing AD pathology, as well as the development of pathology in brain regions not typically expressed in AD Tg mice. In the wt mice, there was delayed motor recovery and an accelerated development of cognitive deficits in aged mice compared to young adult mice following stroke. This corresponded with increased brain atrophy, increased cholinergic degeneration, and a focal increase of Aβ in areas of axonal degeneration in the ipsilateral hemisphere of the aged animals. By contrast, in the hAPP-SL mice, we found that ischemia induced aggravated behavioral deficits in conjunction with a global increase in Aβ, tau, and cholinergic pathology compared to hAPP-SL mice that underwent a sham stroke procedure. With regard to a potential mechanism, in both models, we found that the stroke-induced Aβ and tau deposits co-localized with increased levels of β-secretase 1 (BACE1), along with its substrate, neuregulin 1 (NGR1) type III, both of which are proteins integral for myelin repair. Based on these findings, we propose that the chronic sequelae of stroke may be ratcheting-up a myelin repair pathway, and that the consequent increase in BACE1 could be causing an inadvertent cleavage of its alternative substrate, AβPP, resulting in greater Aβ seeding and pathogenesis.

show abstract

Section: Resultsmentioning

confidence: 99%

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Nguyen

Hayes

Zbesko

et al. 2018

acta neuropathol commun

View full text Add to dashboard Cite

show abstract

“…Some of the identified informative features are consistent with previous literature in its relationship to frailty. Dementia, the first split in the decision tree, has a one-to-one correspondence with frailty in the CFS [28][29], and was shown to have a positive relationship with the Frailty Index (14). The appearance of "vitamins" being prescribed in the medications table may be related to age or nutrition as malnutrition is associated with increased frailty [30], and that nutritional supplementation (including the prescribing of vitamins) has been shown to be a potential therapy for frailty [31][32][33][34].…”

Section: Number Of Features Examplementioning

confidence: 99%

Developing and validating a primary care EMR-based frailty definition using machine learning

Williamson

Aponte-Hao

Mele

et al. 2020

IJPDS

View full text Add to dashboard Cite

Introduction. Individuals who have been identified as frail have an increased state of vulnerability, often leading to adverse health events, increased health spending, and potentially detrimental outcomes. Objective. The objective of this work is to develop and validate a case definition for frailty that can be used in a primary care electronic medical record database. Methods. This is a cross-sectional validation study using data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) in Southern Alberta. 52 CPCSSN sentinels assessed a random sample of their own patients using the Rockwood Clinical Frailty scale, resulting in a total of 875 patients to be used as reference standard. Patients must be over the age of 65 and have had a clinic visit within the last 24 months. The case definition for frailty was developed using machine learning methods using CPCSSN records for the 875 patients. Results. Of the 875 patients, 155 (17.7%) were frail and 720 (84.2%) were not frail. Validation metrics of the case definition were: sensitivity and specificity of 0.28, 95% CI (0.21 to 0.36) and 0.94, 95% CI (0.93 to 0.96), respectively; PPV and NPV of 0.53, 95% CI (0.42 to 0.64) and 0.86, 95% CI (0.83 to 0.88), respectively. Conclusion. The low sensitivity and specificity results could be because frailty as a construct remains under-developed and relatively poorly understood due to its complex nature. These results contribute to the literature by demonstrating that case definitions for frailty require expert consensus and potentially more sophisticated algorithms to be successful

show abstract

“…Cognitive impairment is becoming more prevalent in older persons, and the consequences of dementia for this population are an increasingly worrying public health issue 1 . Thus, the study of diseases and syndromes most present in the elderly population is critical in order to contribute to the promotion and restoration of their health and quality of life 2 .…”

Section: Introductionmentioning

confidence: 99%

Frailty and cognitive performance in older adults living in the community: a cross-sectional study

Fabrício

Alexandre

Chagas

2019

Arch. Clin. Psychiatry (São Paulo)

View full text Add to dashboard Cite

Background: Cognitive impairment and frailty are important problems affecting the elderly population. Frail elderly present worse overall cognitive performance. Objective: The aim of this study was to investigate general and domain-specific cognitive performance among non-frail, pre-frail, and frail elderly persons. Methods: This is a cross-sectional study in which 267 elderly persons living in São Carlos, SP were divided into three groups according to the frailty criteria defined by Fried et al. Cognitive performance was evaluated with a battery of cognitive tests covering domains such as memory, attention, language, and executive functioning. A multinomial logistic regression analysis adjusted for age, gender, and education was performed to evaluate the association between performance in cognitive domains and levels of frailty. Results: Frailty was significantly associated with lower scores on the global cognitive test (RRR = 0.86; IC 95% 0.78-0.96; p < 0.01), word list memory (RRR = 0.92; IC 95% 0.86-0.99; p = 0.02), and figure list recognition (RRR = 0.78; IC 95% 0.62-0.99; p = 0.04). Pre-frailty was associated with lower scores on the word list memory (RRR = 0.92; IC 95% 0.86-1.00; p = 0.04) and naming test (RRR = 0.82; IC 95% 0.69-0.99; p = 0.03). Discussion: Frailty syndrome can influence general cognition and specific domains such as memory and language. Prospective studies will be fundamental to evaluate the causal relation between frailty and cognition.

show abstract

Frailty in relation to the risk of Alzheimer's disease, dementia, and death in older Chinese adults: A seven-year prospective study

Abstract: Frailty was associated with Alzheimer's disease and dementia over a seven years period. Frailty index might facilitate the identification of older adults at high risk of dementia for the application of the most effective, targeted prevention strategies.

Cited by 22 publications

References 39 publications

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Alzheimer’s associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Developing and validating a primary care EMR-based frailty definition using machine learning

Frailty and cognitive performance in older adults living in the community: a cross-sectional study

Contact Info

Product

Resources

About